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Active Recombinant Rat Rtn4 protein, IgG1-tagged

Cat.No. : Rtn4-924R
Product Overview : Recombinant Rat Rtn4(Thr544 - Phe725) fused with Human IgG1(Pro100 - Lys330) at C-terminal was expressed in NS0.
  • Specification
  • Gene Information
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Source : Mammalian cells
Species : Rat
Tag : Fc
Predicted N Terminal : Thr544
Form : Lyophilized from a 0.2 μm filtered solution in PBS.
Bio-activity : Measured by its ability to inhibit neurite outgrowth of dissociated E13 chick embryonic dorsal root ganglia (DRG) neurons. Able to significantly inhibit neurite outgrowth when immobilized as a 3 µL droplet containing 300 ng on a nitrocellulose-coated microplate.
Molecular Mass : Predicted Molecular Mass: 46.1 (monomer) kDa;SDS-PAGE: 75-85 kDa, reducing conditions.
Endotoxin : <0.10 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Storage : Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : Reconstitute at 100 μg/mL in sterile PBS.
Gene Name : Rtn4 reticulon 4 [ Rattus norvegicus ]
Official Symbol : Rtn4
Synonyms : RTN4; reticulon 4; reticulon-4; foocen; NI-220/250; nogo protein; GLUT4 vesicle 20kDa protein; neurite outgrowth inhibitor; glut4 vesicle 20 kDa protein; r; Nogo; Vp20; rat N; NI-250; Nogo-A; rat NogoA; MGC116054;
Gene ID : 83765
mRNA Refseq : NM_031831
Protein Refseq : NP_114019
Chromosome Location : 14q22
Pathway : Axonal growth inhibition (RHOA activation), organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signalling by NGF, organism-specific biosystem; p75 NTR receptor-mediated signalling, organism-specific biosystem; p75NTR regulates axonogenesis, organism-specific biosystem;
Function : protein binding; protein complex binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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