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Recombinant Rat TACSTD2 Protein (Met1-Gly270), His-tagged

Cat.No. : TACSTD2-971R
Product Overview : Recombinant Rat TACSTD2 Protein (NP_001009540.2) (Met1-Gly270) was produced by HEK293 Cells expression system. This protein was expressed with a polyhistidine tag at the C-terminus.
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  • Gene Information
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Description : TROP-2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.
Source : HEK293
Species : Rat
Tag : His
Predicted N Terminal : Gln 20
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant rat TACSTD2 consists of 257 amino acids and predicts a molecular mass of 29.5 kDa.
Protein length : Met1-Gly270
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 90 % as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -70 centigrade.
Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Shipping : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name : Tacstd2 tumor-associated calcium signal transducer 2 [ Rattus norvegicus ]
Official Symbol : TACSTD2
Synonyms : TACSTD2; tumor-associated calcium signal transducer 2; parturition-related protein 1; Prp1; MGC72570;
Gene ID : 494343
mRNA Refseq : NM_001009540
Protein Refseq : NP_001009540
UniProt ID : Q6P9Z6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What diagnostic techniques are used to assess TACSTD2 levels in cancer patients? 11/29/2022

Immunohistochemistry and PCR-based assays are common techniques to measure TACSTD2 expression in cancer tissues.

How does TACSTD2 contribute to cancer metastasis? 05/17/2020

TACSTD2 promotes cancer cell migration and invasion, leading to metastasis by interacting with various signaling pathways.

Are there clinical trials involving TACSTD2-targeted therapies for cancer treatment? 11/06/2018

Yes, there are ongoing clinical trials testing TACSTD2-targeted therapies, including antibody-drug conjugates and immunotherapies.

What are the potential side effects of TACSTD2-targeted therapies? 09/29/2017

Common side effects can include fatigue, nausea, diarrhea, and skin rashes, similar to other cancer treatments.

Are there any targeted therapies that focus on TACSTD2? 04/30/2017

Yes, monoclonal antibodies and antibody-drug conjugates targeting TACSTD2 are being investigated for cancer treatment.

Customer Reviews (3)

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Reviews
06/05/2020

    In addition to its advantages in trials, the manufacturer of the TACSTD2 protein offers exceptional support to researchers.

    06/11/2018

      Their team of technical experts possess deep knowledge and expertise regarding the protein, ensuring that researchers receive accurate and timely assistance.

      01/24/2018

        the TACSTD2 protein has been extensively studied and validated in various experimental applications.

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