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Recombinant Rat Tigit protein, His & T7-tagged

Cat.No. : Tigit-1441R
Product Overview : Recombinant Rat Tigit aa. (Met28~Ser227 (Accession # D3ZTQ2)) fused with N-terminal His & T7 tag was produced in E. coli cells.
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  • Gene Information
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Source : E. coli
Species : Rat
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 25.7kDa
Protein length : Met28~Ser227 (Accession # D3ZTQ2)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Isoelectric Point : 5.4
Gene Name : Tigit T cell immunoreceptor with Ig and ITIM domains [ Rattus norvegicus (Norway rat) ]
Official Symbol : Tigit
Synonyms : Tigit; T cell immunoreceptor with Ig and ITIM domains; RGD1563191; T-cell immunoreceptor with Ig and ITIM domains
Gene ID : 363784
mRNA Refseq : XM_017598162.1
Protein Refseq : XP_017453651.1
UniProt ID : D3ZTQ2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In which types of cancers is TIGIT inhibition being investigated? 12/02/2022

TIGIT inhibitors are being studied in a range of cancers, including lung cancer, breast cancer, and melanoma, among others.

How is TIGIT relevant in autoimmune diseases? 05/14/2022

TIGIT is being explored as a potential target for treating autoimmune diseases by modulating immune responses to prevent excessive inflammation.

What clinical applications does TIGIT have in cancer therapy? 06/11/2020

TIGIT is being explored as a potential target for cancer immunotherapy, with drugs designed to block TIGIT and enhance the immune system's ability to attack cancer cells.

How does TIGIT differ from other immune checkpoint proteins like PD-1 and CTLA-4? 04/22/2020

TIGIT operates as an immune checkpoint, similar to PD-1 and CTLA-4, but it has distinct mechanisms of action and may regulate different aspects of the immune response.

Are there any potential side effects associated with TIGIT-targeted therapies? 01/12/2016

As with any immunotherapy, potential side effects may include immune-related adverse events such as inflammation in various organs, but the specific profile is still under investigation.

Customer Reviews (3)

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Reviews
11/25/2022

    With its well-characterized nature and availability in various formats, the TIGIT protein is an advantageous tool that aids researchers in achieving their scientific goals.

    08/05/2017

      Whether it's troubleshooting issues, optimizing experimental protocols, or providing detailed information about the protein, the manufacturer's support team is dedicated to helping researchers overcome any challenges they may encounter.

      05/21/2017

        The manufacturer also ensures that the TIGIT protein is well-characterized, with extensive documentation on its functional properties.

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