Recombinant Sheep IL12B Protein (23-327 aa), His-tagged

• Cat.No.: IL12B-576S
• Product Overview: Recombinant Sheep IL12B Protein (23-327 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Full Length of Mature Protein.

Specification

• Description: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates mory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
• Source: E. coli
• Species: Sheep
• Tag: His
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 38.5 kDa
• Protein length: 23-327 aa
• AA Sequence: IWELEKNVYVVELDWYPNAPGETVV LTCDTPEEDGITWTSDQSSEVLGSG KTLTIQVKEFGDAGQYTCHKGGEVL SRSLLLLHKKEDGIWSTDILKDQKE PKAKSFLKCEAKDYSGHFTCSWLTA ISTNLKFSVKSSRGSSDPRGVTCGA ASLSAEKVSMDHREYNKYTVECQEG SACPAAEESLPIEVVMEAVHKLKYE NYTSSFFIRDIIKPDPPKNLQLRPL KNSRQVEVSWEYPDTWSTPHSYFSL TFCVQVQGKNKREKKLFTDQTSAKV TCHKDANIRVQARDRYYSSFWSEWA SVSCS
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [ Ovis aries ]
• Official Symbol: IL12B
• Synonyms: IL12B; IL-12B; CLMF p40; IL-12 subunit p40; IL-12
• Gene ID: 443472
• mRNA Refseq: NM_001009438
• Protein Refseq: NP_001009438
• UniProt ID: P68220