Recombinant Sheep IL12B Protein (23-327 aa), His-tagged
Cat.No. : | IL12B-576S |
Product Overview : | Recombinant Sheep IL12B Protein (23-327 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Full Length of Mature Protein. |
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Description : | Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates mory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
Source : | E. coli |
Species : | Sheep |
Tag : | His |
Form : | Tris-based buffer, 50% glycerol |
Molecular Mass : | 38.5 kDa |
Protein length : | 23-327 aa |
AA Sequence : | IWELEKNVYVVELDWYPNAPGETVV LTCDTPEEDGITWTSDQSSEVLGSG KTLTIQVKEFGDAGQYTCHKGGEVL SRSLLLLHKKEDGIWSTDILKDQKE PKAKSFLKCEAKDYSGHFTCSWLTA ISTNLKFSVKSSRGSSDPRGVTCGA ASLSAEKVSMDHREYNKYTVECQEG SACPAAEESLPIEVVMEAVHKLKYE NYTSSFFIRDIIKPDPPKNLQLRPL KNSRQVEVSWEYPDTWSTPHSYFSL TFCVQVQGKNKREKKLFTDQTSAKV TCHKDANIRVQARDRYYSSFWSEWA SVSCS |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA with concentration instruction is sent along with the products. |
Gene Name : | IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [ Ovis aries ] |
Official Symbol : | IL12B |
Synonyms : | IL12B; IL-12B; CLMF p40; IL-12 subunit p40; IL-12; |
Gene ID : | 443472 |
mRNA Refseq : | NM_001009438 |
Protein Refseq : | NP_001009438 |
UniProt ID : | P68220 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewGood for cytokine assays.
Effective in Th2 cell differentiation.
High yield in expression.
Q&As (10)
Ask a questionChIP-seq identifies regulatory elements controlling IL12B gene expression.
Reporter assays monitor IL12B promoter activity under varying conditions.
Primary cell stimulation assays gauge IL12B response to pathogens.
siRNA knockdown uncovers IL12B's role in immune cell activation pathways.
Recombinant protein expression enables functional IL12B studies in vitro.
Co-IP validates IL12B's binding to specific signaling partners.
Genetic variant analysis reveals impacts on IL12B protein function.
Flow cytometry profiles IL12B expression across diverse immune cell types.
Cytokine secretion assays measure IL12B's response kinetics to stimuli.
Co-IP and immunoprecipitation assess IL12B's interactions with other proteins.
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