Recombinant Yeast ALS3 Protein (918-1119 aa), His-B2M-Myc-tagged

• Cat.No.: ALS3-2175Y
• Product Overview: Recombinant Yeast ALS3 Protein (918-1119 aa) is produced by E. coli expression system. This protein is fused with a 10xHis-B2M tag at the N-terminal and a Myc tag at the C-terminal. Protein Description: Partial.

Specification

• Description: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells.
• Source: E. coli
• Species: Yeast
• Tag: His-B2M-Myc
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 37.9 kDa
• Protein length: 918-1119 aa
• AA Sequence: VSVETESSTVTTAQTNPSVPTTESE VVFTTKGNNENGPYESPSTNVKSSM DENSEFTTSTAASTSTDIENETIAT TGSVEASSPIISSSADETTTVTTTA ESTSVIEQPTNNNGGGKAPSATSSP STTTTANNDSVITGTTSTNQSQSQS QYNSDTQQTTLSQQMTSSLVSLHML TTFDGSGSVIQHSTWLCGLITLLSL FI
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.
• Synonyms: ALS3; 3D9 antigen Adhesin 3
• UniProt ID: O74623

Gene Information

• Synonyms: ALS3; 3D9 antigen Adhesin 3
• UniProt ID: O74623

Reviews

10/12/2021

Reliable detection of protein post-translational modifications.

04/18/2018

Compatibility with various protein analysis techniques (e.g., mass spectrometry).

01/17/2018

High assay sensitivity without signal saturation.

Q&As

How does ALS3 contribute to the pathogenesis of ALS, and what are the underlying molecular mechanisms?

ALS3 contributes to the pathogenesis of ALS through multiple mechanisms, including mitochondrial dysfunction, impaired protein homeostasis, and dysregulated signaling pathways.

Does ALS3 play a role in mitochondrial function or dynamics, and how does it impact cellular energy metabolism?

ALS3 influences mitochondrial function and dynamics, affecting processes such as mitochondrial respiration, ATP production, or mitochondrial fission and fusion.

Can therapeutic interventions targeting ALS3 or its associated pathways offer potential strategies for treating ALS or related neurodegenerative disorders?

Therapeutic interventions targeting ALS3 or its associated pathways hold promise for treating ALS and related neurodegenerative disorders by modulating mitochondrial function, protein homeostasis, or downstream signaling pathways implicated in disease pathology.

What are the functional domains or motifs present in ALS3, and how do they contribute to its molecular functions?

ALS3 contains functional domains and motifs, such as RNA-binding domains, prion-like domains, or regions involved in protein-protein interactions, which play a role in its molecular functions.

How does ALS3 expression change during disease progression, and are there any factors or conditions that regulate its expression levels?

ALS3 expression is altered during disease progression, with increased levels in affected tissues or specific cell types. Factors such as cellular stress, inflammation, or genetic mutations can regulate ALS3 expression.

What are the downstream signaling pathways or transcriptional targets regulated by ALS3, and how do they contribute to ALS pathology?

ALS3 regulates downstream signaling pathways, including those involving kinases, transcription factors, or inflammatory mediators, contributing to neuroinflammation, oxidative stress, or neuronal death.

Can the protein-protein interactions of ALS3 be identified and characterized, and how do they influence its cellular functions?

ALS3 interacts with various proteins, such as chaperones, RNA-binding proteins, or components of the ubiquitin-proteasome system, forming dynamic protein complexes that modulate its cellular functions.

Can the enzymatic activities of ALS3 be characterized, and what are its potential substrates or targets?

The enzymatic activities of ALS3 are not well-characterized, and further studies are needed to determine its potential enzymatic functions and identify its substrates or targets.

Is ALS3 involved in the regulation of protein homeostasis, including protein folding, degradation, or aggregation?

ALS3 is involved in the regulation of protein homeostasis, including protein folding, clearance of misfolded proteins, and prevention of protein aggregation.

What are the cellular and subcellular localization patterns of ALS3, and how do they vary in different cell types or conditions?

ALS3 shows a predominantly cytoplasmic localization, with potential accumulation in specific subcellular compartments, such as stress granules or mitochondria, under certain conditions.