|Official Full Name||alpha-2-macroglobulin|
|Background||Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]|
|Synonyms||A2M; alpha-2-macroglobulin; A2MD; CPAMD5; FWP007; S863-7; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
A2M involved in several pathways and played different roles in them. We selected most pathways A2M participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with A2M were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Complement and coagulation cascades||SERPINA1D; MBL1; C6; CFI; CD46; THBD; SERPINA1E; C4BP; SERPIND1; F8|
A2M has several biochemical functions, for example, calcium-dependent protein binding, enzyme binding, growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by A2M itself. We selected most functions A2M had, and list some proteins which have the same functions with A2M. You can find most of the proteins on our site.
|calcium-dependent protein binding||CPNE3; RAC3; STX2; ANXA6; NRXN1; MYO1D; ANXA11; ANXA3; MMP13; ANXA7|
|enzyme binding||APBA3; ARRB2; CABYR; ESR2; GSTM1; PLAUR; TUT1; CCDC99; PDE4DIP; KMT2E|
|growth factor binding||KDR; NRP1; RPL37; IL6ST; IGFBP2B; LTBP4; GHRHR; TEK; ERBB3; FGFBP2|
|interleukin-1 binding||A2M; TRIM16; HAX1|
|interleukin-8 binding||CXCR1; CXCR2; A2M|
|protease binding||POLG; CSTA; THAP5; STIM1; SERPINC1; INS1; CNTNAP2; CD28; SERPINB9; INS2|
|protein binding||VPS11; LRRC3; MON2; SCRN1; RNF216; FABP1; ENG; SEMA4C; CABLES1; TMEM8B|
|receptor binding||FIS1; IDH1; FGF8B; C1QTNF2; FGF6A; WNT7AA; DPP4; POU2F1; MLYCD; TRIM24|
|serine-type endopeptidase inhibitor activity||SERPINA10A; SERPINA5; SERPIND1; SERPINA12; SPINT1; MUG1; SERPINB1B; WFDC10A; APPB; PZP|
|tumor necrosis factor binding||Tnfrsf26; TNFRSF1A; A2M|
A2M has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with A2M here. Most of them are supplied by our site. Hope this information will be useful for your research of A2M.
SMAP; ADAMTS12; ADAMTS7; IL1B; KLK3; MMP2; IL10; SPACA3; IFIT3; NUDT21; MGEA5; CDK2AP2; RPP14; APOE; TTR; TK1; APP; CYP2C8; UMPS