adam17
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  • Official Full Name
  • ADAM metallopeptidase domain 17
  • Background
  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ADAM17; ADAM metallopeptidase domain 17; CSVP; TACE; NISBD; ADAM18; CD156B; disintegrin and metalloproteinase domain-containing protein 17; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; ADAM metallopeptidase domain 18; tumor necrosis factor, alpha, converting enzyme;
Cat.#:Adam17-522MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse A Disintegrin And Metallopeptidase Domain 17, His-tagged
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Cat.#:ADAM17-278HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADAM17 Protein, GST-tagged
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Cat.#:ADAM17-593HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ADAM17
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Cat.#:ADAM17-7114HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADAM17 protein, His-tagged
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Cat.#:Adam17-256MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Adam17 protein, His-tagged
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Cat.#:ADAM17-501RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ADAM17 Protein
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Cat.#:Adam17-7115RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Adam17 protein, His & T7-tagged
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Cat.#:Adam17-8788RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Adam17, His tagged
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Cat.#:ADAM17-1867CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ADAM17
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Cat.#:ADAM17-592HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ADAM Metallopeptidase Domain 17, His-tagged
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Cat.#:ADAM17-1198RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat ADAM17 cell lysate
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Cat.#:Kit-0048Tag:
Source (Host):Species:
Product nameADAM17 fluorometric drug discovery Kit
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Cat.#:Kit-0049Tag:
Source (Host):Species:
Product nameADAM17 Inhibitor Screening Assay Kit
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Involved Pathway

ADAM17 involved in several pathways and played different roles in them. We selected most pathways ADAM17 participated on our site, such as Notch signaling pathway, Alzheimers disease, Epithelial cell signaling in Helicobacter pylori infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Notch signaling pathway
APH1C; NOTCH3; HER15.1; NOTCH1B; NUMB; MAML1; MFAP5; KAT2A; MIB1; CTBP2
Alzheimers disease
PLCB1; Casp3; CALM4; NDUFA4L2; SDHC; COX7B2; NDUFB3; COX7B; COX6A1; NDUFB2
Epithelial cell signaling in Helicobacter pylori infection
IKBKG; ATP6V1A; PLCG2; ATP6V0A2; MAPK10; ATP6V0D2; CCL5; ATP6V0A4; CDC42; NOD1

Protein Function

ADAM17 has several biochemical functions, for example, Notch binding, PDZ domain binding, SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM17 itself. We selected most functions ADAM17 had, and list some proteins which have the same functions with ADAM17. You can find most of the proteins on our site.
Function
Related Protein
Function Notch binding
Related Protein NOTCH4; ADAM17; NOV; DLL4; JAG1A; JAG2B; DLL3; JAG1B; SNW1; DLL1
Function PDZ domain binding
Related Protein ATP2B1B; LIN7C; SLC26A6; CXXC4; LLGL2; ACOX1; SSTR2; GRIA1; ARHGAP29; GRIK2
Function SH3 domain binding
Related Protein PDCD6IP; RAD9; WAS; FMN1; SH3BP5B; RAD9A; LANCL1; PLSCR1; WIPF3; UVRAG
Function integrin binding
Related Protein IGF1; CYR61L1; NF2; ICAM3; PXN; CD151; DST; ANGPTL3; LAMA5; ESM1
Function interleukin-6 receptor binding
Related Protein ADAM17; IL6; PYCARD; ERAP1; CNTF
Function metalloendopeptidase activity
Related Protein ADAM5; ADAMTS10; ADAM10A; UQCRC1; ADAM30; ADAM23; ADAM9; ADAM10B; MMP7; MEP1A
Function metallopeptidase activity
Related Protein ADAMTS16; AGBL4; ADAM5; ADAMTS4; ADAM23; PAPLNB; MMP1A; ADAMTSL1; STAMBPA; STAMBPL1
Function protein binding
Related Protein EIF4EA; NR3C2; PFDN4; PAK6; COQ9; TNIP1; FOXJ2; MICU1; CAND2; CDAN1
Function zinc ion binding
Related Protein ANAPC11; KDM7AB; MYLIP; DNAJC24; RNF175; RNF141; ADAM17A; AFG3L2; YAF2; CLIP1

Interacting Protein

ADAM17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM17 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM17.
DLG1; MAD2L1; APP; ITGB1; PDIA3; JAG1; TGFA; PTPN3; thiF; Sgol2

ADAM17 Related Articles

Li, GR; Forest, F; et al. A novel marker ADAM 17 for clear cell renal cell carcinomas: Implication for patients' prognosis. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 32:1272-1276(2014).
Arenaccio, C; Chiozzini, C; et al. Exosomes from Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Cells License Quiescent CD4(+) T Lymphocytes To Replicate HIV-1 through a Nef- and ADAM17-Dependent Mechanism. JOURNAL OF VIROLOGY 88:11529-11539(2014).