Active Recombinant Rat Adam17 protein(Met1-Asp563), His-tagged
Cat.No. : | Adam17-8788R |
Product Overview : | Recombinant Rat ADAM17 (Q9Z1K9) (Met1-Asp563) was expressed in HEK293 with a polyhistidine tag at the C-terminus. |
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Source : | HEK293 |
Species : | Rat |
Tag : | His |
Protein length : | Met1-Asp563 |
Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Bio-activity : | Measured by its ability to cleave a fluorogenic peptide substrate Mca-PLAQAV-Dpa-RSSSR-NH2 (Catalog # ES003). The specific activity is >250 pmol/min/μg. |
Molecular Mass : | The recombinant rat ADAM17 comprises 557 amino acids and predicts a molecular mass of 63 kDa. The apparent molecular mass of the recombinant protein is approximately 57 and 20 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | > 95 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | Adam17 ADAM metallopeptidase domain 17 [ Rattus norvegicus ] |
Official Symbol : | Adam17 |
Synonyms : | ADAM17; ADAM metallopeptidase domain 17; disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; a disintegrin and metalloprotease domain 17; a disintegrin and metallopeptidase domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); TACE; |
Gene ID : | 57027 |
mRNA Refseq : | NM_020306 |
Protein Refseq : | NP_064702 |
Products Types
◆ Recombinant Protein | ||
Adam17-308M | Recombinant Mouse Adam17 Protein, His (Fc)-Avi-tagged | +Inquiry |
ADAM17-073R | Recombinant Rat ADAM17 Protein, His-tagged | +Inquiry |
ADAM17-157R | Recombinant Rat ADAM17 Protein, His (Fc)-Avi-tagged | +Inquiry |
ADAM17-085M | Recombinant Mouse ADAM17 Protein, His-tagged | +Inquiry |
ADAM17-7114H | Recombinant Human ADAM17 protein, His-tagged | +Inquiry |
◆ Lysates | ||
ADAM17-1198RCL | Recombinant Rat ADAM17 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0048 | ADAM17 fluorometric drug discovery Kit | +Inquiry |
Kit-0049 | ADAM17 Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
Not For Human Consumption!
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Customer Reviews (3)
Write a reviewCheap price, high quality products, worth buying again
The high quality of the purchased protein helped me to obtain satisfactory experimental results.
Good after-sales service attitude, helped me solve a lot of problems in the experiment.
Q&As (10)
Ask a questionADAM17 is a negative regulator of the RAS system.
Yes, we have produced ADAM17 protein of this purity.
ADAM17 protein can cleave IL6R, TNFR1, ACE2, etc.
ADAM17 is widely expressed in somatic and immune cells
ADAM17 is also currently being used in studies of breast cancer and gastric cancer, etc.
ADAM17 is an activator that mediates the EGFR-PI3K-AKT pathway.
The product manual will contain relevant content on product handling, and you can also consult our technical experts on related issues.
Yes, ADAM17 protein is involved in this promotion.
ADAM17 acts as an activator of Notch pathway by mediating the of cleavage of Notch.
Addition of His tags usually does not affect the function, properties of the target protein.
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