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Active Recombinant Human ADAM17

Cat.No. : ADAM17-593H
Product Overview : Recombinant Human ADAM17 was expressed in Insect cells.
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Description : This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.
Source : Insect cells
Species : Human
Form : Lyophilised
Bio-activity : Activity was tested using the synthetic peptide, Abz-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Dpa(Dnp)-NH2, as a substrate. Specific activity = 280 units/mg.
Molecular Mass : 62 kDa
Protein length : 215 to 651
AA Sequence : RADPDPMKNTCKLLVVADHRFYRYM GRGEESTTTNYLIELIDRVDDIYRN TSWDNAGFKGYGIQIEQIRILKS PQEVKPGEKHYNMAKSYPNEEKDAW DVKMLLEQFSFDIAEEASKVCLAHL FTYQDFDMGTLGLAY VGSPRANSHGGVCPKAYYSPVGKKN IYLNSGLTSTKNYGKTILTKEADLV TTHELGHNFGAEHDP DGLAECAPNEDQGGKYVMYPIAVSG DHENNKMFSNCSKQSIYKTIESKAQ ECFQERSNKVCGNSR VDEGEECDPGIMYLNNDTCCNS DCTLKEGVQC SDRNSPCCKNCQFETAQKKCQEAIN ATCKGVSYCTGNSSECPPPGNAEDD TVCLDLGKCK DGKCIPFCEREQQLESCACNETDNS CKVCCRDLSGRCVPYVDAEQKNLFL RKGKPCTVGF CDMNGKCEKRVQDVIER
Purity : >90% by SDS-PAGE.
Applications : Functional Studies; SDS-PAGE
Storage : Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Reconstitution : Reconstitute with sterile deionized water at 0.1µg protein/µl. For long term storage, it is recommended to add a carrier protein (0.1% BSA). Avoid multiple freeze/thaw cycles.
Tag : Non
Gene Name : ADAM17 ADAM metallopeptidase domain 17 [ Homo sapiens (human) ]
Official Symbol : ADAM17
Synonyms : ADAM17; CSVP; TACE; NISBD; ADAM18; CD156B; ADAM metallopeptidase domain 17; disintegrin and metalloproteinase domain-containing protein 17; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; ADAM metallopeptidase domain 18; tumor necrosis factor, alpha, converting enzyme; NP_003174.3; EC 3.4.24.86
Gene ID : 6868
mRNA Refseq : NM_003183
Protein Refseq : NP_003174
MIM : 603639
UniProt ID : P78536
Chromosome Location : 2p25
Pathway : Activated NOTCH1 Transmits Signal to the Nucleus; BDNF signaling pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants
Function : Notch binding; PDZ domain binding; interleukin-6 receptor binding

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
04/08/2022

    Cheap price, high quality products, worth buying again

    03/15/2019

      The high quality of the purchased protein helped me to obtain satisfactory experimental results.

      02/26/2019

        Good after-sales service attitude, helped me solve a lot of problems in the experiment.

        Q&As (10)

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        Is ADAM17 protein involved in the renin-angiotensin system? 08/01/2022

        ADAM17 is a negative regulator of the RAS system.

        My research requires high protein purity, can I customize > 90% ADAM17 protein? 06/05/2022

        Yes, we have produced ADAM17 protein of this purity.

        What proteins does ADAM17 cleave? 04/07/2022

        ADAM17 protein can cleave IL6R, TNFR1, ACE2, etc.

        Where ADAM17 is highly expressed? 06/25/2021

        ADAM17 is widely expressed in somatic and immune cells

        In addition to Diabetes mellitus and cardiomyopathy-related research, ADAM17 is currently used in the research of which diseases? 01/21/2021

        ADAM17 is also currently being used in studies of breast cancer and gastric cancer, etc.

        Is ADAM17 associated with the EGFR-PI3K-AKT pathway? 10/03/2020

        ADAM17 is an activator that mediates the EGFR-PI3K-AKT pathway.

        Does the package insert for ADAM17 contain detailed information on the handling of the lyophilized powder product? 04/19/2020

        The product manual will contain relevant content on product handling, and you can also consult our technical experts on related issues.

        ADAM17 protein is also involved in recent activities? 12/11/2019

        Yes, ADAM17 protein is involved in this promotion.

        Does ADAM17 mediate the Notch pathway? 10/05/2019

        ADAM17 acts as an activator of Notch pathway by mediating the of cleavage of Notch.

        Does adding His tag have any effect on protein? 04/24/2019

        Addition of His tags usually does not affect the function, properties of the target protein.

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