Active Recombinant Human ADAM17
Cat.No. : | ADAM17-593H |
Product Overview : | Recombinant Human ADAM17 was expressed in Insect cells. |
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Description : | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. |
Source : | Insect cells |
Species : | Human |
Form : | Lyophilised |
Bio-activity : | Activity was tested using the synthetic peptide, Abz-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Dpa(Dnp)-NH2, as a substrate. Specific activity = 280 units/mg. |
Molecular Mass : | 62 kDa |
Protein length : | 215 to 651 |
AA Sequence : | RADPDPMKNTCKLLVVADHRFYRYM GRGEESTTTNYLIELIDRVDDIYRN TSWDNAGFKGYGIQIEQIRILKS PQEVKPGEKHYNMAKSYPNEEKDAW DVKMLLEQFSFDIAEEASKVCLAHL FTYQDFDMGTLGLAY VGSPRANSHGGVCPKAYYSPVGKKN IYLNSGLTSTKNYGKTILTKEADLV TTHELGHNFGAEHDP DGLAECAPNEDQGGKYVMYPIAVSG DHENNKMFSNCSKQSIYKTIESKAQ ECFQERSNKVCGNSR VDEGEECDPGIMYLNNDTCCNS DCTLKEGVQC SDRNSPCCKNCQFETAQKKCQEAIN ATCKGVSYCTGNSSECPPPGNAEDD TVCLDLGKCK DGKCIPFCEREQQLESCACNETDNS CKVCCRDLSGRCVPYVDAEQKNLFL RKGKPCTVGF CDMNGKCEKRVQDVIER |
Purity : | >90% by SDS-PAGE. |
Applications : | Functional Studies; SDS-PAGE |
Storage : | Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles. |
Reconstitution : | Reconstitute with sterile deionized water at 0.1µg protein/µl. For long term storage, it is recommended to add a carrier protein (0.1% BSA). Avoid multiple freeze/thaw cycles. |
Tag : | Non |
Gene Name : | ADAM17 ADAM metallopeptidase domain 17 [ Homo sapiens (human) ] |
Official Symbol : | ADAM17 |
Synonyms : | ADAM17; CSVP; TACE; NISBD; ADAM18; CD156B; ADAM metallopeptidase domain 17; disintegrin and metalloproteinase domain-containing protein 17; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; ADAM metallopeptidase domain 18; tumor necrosis factor, alpha, converting enzyme; NP_003174.3; EC 3.4.24.86 |
Gene ID : | 6868 |
mRNA Refseq : | NM_003183 |
Protein Refseq : | NP_003174 |
MIM : | 603639 |
UniProt ID : | P78536 |
Chromosome Location : | 2p25 |
Pathway : | Activated NOTCH1 Transmits Signal to the Nucleus; BDNF signaling pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants |
Function : | Notch binding; PDZ domain binding; interleukin-6 receptor binding |
Products Types
◆ Recombinant Protein | ||
Adam17-308M | Recombinant Mouse Adam17 Protein, His (Fc)-Avi-tagged | +Inquiry |
ADAM17-073R | Recombinant Rat ADAM17 Protein, His-tagged | +Inquiry |
Adam17-8788R | Active Recombinant Rat Adam17 protein(Met1-Asp563), His-tagged | +Inquiry |
ADAM17-157R | Recombinant Rat ADAM17 Protein, His (Fc)-Avi-tagged | +Inquiry |
ADAM17-085M | Recombinant Mouse ADAM17 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ADAM17-1198RCL | Recombinant Rat ADAM17 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0048 | ADAM17 fluorometric drug discovery Kit | +Inquiry |
Kit-0049 | ADAM17 Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
Not For Human Consumption!
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Customer Reviews (3)
Write a reviewCheap price, high quality products, worth buying again
The high quality of the purchased protein helped me to obtain satisfactory experimental results.
Good after-sales service attitude, helped me solve a lot of problems in the experiment.
Q&As (10)
Ask a questionADAM17 is a negative regulator of the RAS system.
Yes, we have produced ADAM17 protein of this purity.
ADAM17 protein can cleave IL6R, TNFR1, ACE2, etc.
ADAM17 is widely expressed in somatic and immune cells
ADAM17 is also currently being used in studies of breast cancer and gastric cancer, etc.
ADAM17 is an activator that mediates the EGFR-PI3K-AKT pathway.
The product manual will contain relevant content on product handling, and you can also consult our technical experts on related issues.
Yes, ADAM17 protein is involved in this promotion.
ADAM17 acts as an activator of Notch pathway by mediating the of cleavage of Notch.
Addition of His tags usually does not affect the function, properties of the target protein.
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