Species : |
Human |
Source : |
Insect Cells |
Tag : |
Non |
Protein Length : |
215 to 651 |
Description : |
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. |
Form : |
Lyophilised |
Bio-activity : |
Activity was tested using the synthetic peptide, Abz-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Dpa(Dnp)-NH2, as a substrate. Specific activity = 280 units/mg. |
Molecular Mass : |
62 kDa |
AA Sequence : |
RADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKS PQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAY VGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDP DGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSR VDEGEECDPGIMYLNNDTCCNS DCTLKEGVQC SDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDD TVCLDLGKCK DGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFL RKGKPCTVGF CDMNGKCEKRVQDVIER |
Purity : |
>90% by SDS-PAGE. |
Applications : |
Functional Studies; SDS-PAGE |
Storage : |
Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles. |
Reconstitution : |
Reconstitute with sterile deionized water at 0.1µg protein/µl. For long term storage, it is recommended to add a carrier protein (0.1% BSA). Avoid multiple freeze/thaw cycles. |