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Recombinant Human ADAM17 Protein, GST-tagged

Cat.No. : ADAM17-278H
Product Overview : Human ADAM17 partial ORF ( NP_003174, 215 a.a. - 314 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 36.74 kDa
AA Sequence : RADPDPMKNTCKLLVVADHRFYRYM GRGEESTTTNYLIELIDRVDDIYRN TSWDNAGFKGYGIQIEQIRILKSPQ EVKPGEKHYNMAKSYPNEEKDAWDV
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ADAM17 ADAM metallopeptidase domain 17 [ Homo sapiens ]
Official Symbol : ADAM17
Synonyms : ADAM17; ADAM metallopeptidase domain 17; TACE, tumor necrosis factor, alpha, converting enzyme; disintegrin and metalloproteinase domain-containing protein 17; CD156B; cSVP; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; ADAM metallopeptidase domain 18; tumor necrosis factor, alpha, converting enzyme; CSVP; TACE; NISBD; ADAM18;
Gene ID : 6868
mRNA Refseq : NM_003183
Protein Refseq : NP_003174
MIM : 603639
UniProt ID : P78536

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Is ADAM17 protein involved in the renin-angiotensin system? 08/01/2022

ADAM17 is a negative regulator of the RAS system.

My research requires high protein purity, can I customize > 90% ADAM17 protein? 06/05/2022

Yes, we have produced ADAM17 protein of this purity.

What proteins does ADAM17 cleave? 04/07/2022

ADAM17 protein can cleave IL6R, TNFR1, ACE2, etc.

Where ADAM17 is highly expressed? 06/25/2021

ADAM17 is widely expressed in somatic and immune cells

In addition to Diabetes mellitus and cardiomyopathy-related research, ADAM17 is currently used in the research of which diseases? 01/21/2021

ADAM17 is also currently being used in studies of breast cancer and gastric cancer, etc.

Is ADAM17 associated with the EGFR-PI3K-AKT pathway? 10/03/2020

ADAM17 is an activator that mediates the EGFR-PI3K-AKT pathway.

Does the package insert for ADAM17 contain detailed information on the handling of the lyophilized powder product? 04/19/2020

The product manual will contain relevant content on product handling, and you can also consult our technical experts on related issues.

ADAM17 protein is also involved in recent activities? 12/11/2019

Yes, ADAM17 protein is involved in this promotion.

Does ADAM17 mediate the Notch pathway? 10/05/2019

ADAM17 acts as an activator of Notch pathway by mediating the of cleavage of Notch.

Does adding His tag have any effect on protein? 04/24/2019

Addition of His tags usually does not affect the function, properties of the target protein.

Customer Reviews (3)

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Reviews
04/08/2022

    Cheap price, high quality products, worth buying again

    03/15/2019

      The high quality of the purchased protein helped me to obtain satisfactory experimental results.

      02/26/2019

        Good after-sales service attitude, helped me solve a lot of problems in the experiment.

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