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Recombinant Human ADAM17 Protein (Met1-Asp563), C-His tagged

Cat.No. : ADAM17-5123H
Product Overview : Recombinant human ADAM17 (Met1-Asp563) fused with the C-terminal His tag was expressed in Mammalian cells.
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Source : Mammalian cells
Species : Human
Tag : His
Form : Lyophilized powder/frozen liquid
Molecular Mass : 61.93 kDa
Protein length : Met1-Asp563
Endotoxin : < 1.0 EU/μg of the protein as determined by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Notes : For research use only.
Storage : Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
Storage Buffer : Supplied as solution form in PBS or lyophilized from PBS.
Reconstitution : Reconstitute in sterile water for a stock solution.
Shipping : They are shipped out with dry ice/blue ice unless customers require otherwise.
Gene Name : ADAM17 ADAM metallopeptidase domain 17 [ Homo sapiens (human) ]
Official Symbol : ADAM17
Synonyms : ADAM17; ADAM metallopeptidase domain 17; TACE, tumor necrosis factor, alpha, converting enzyme; disintegrin and metalloproteinase domain-containing protein 17; CD156B; cSVP; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; ADAM metallopeptidase domain 18; tumor necrosis factor, alpha, converting enzyme; CSVP; TACE; NISBD; ADAM18;
Gene ID : 6868
mRNA Refseq : NM_003183
Protein Refseq : NP_003174
MIM : 603639
UniProt ID : P78536

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
04/08/2022

    Cheap price, high quality products, worth buying again

    03/15/2019

      The high quality of the purchased protein helped me to obtain satisfactory experimental results.

      02/26/2019

        Good after-sales service attitude, helped me solve a lot of problems in the experiment.

        Q&As (10)

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        Is ADAM17 protein involved in the renin-angiotensin system? 08/01/2022

        ADAM17 is a negative regulator of the RAS system.

        My research requires high protein purity, can I customize > 90% ADAM17 protein? 06/05/2022

        Yes, we have produced ADAM17 protein of this purity.

        What proteins does ADAM17 cleave? 04/07/2022

        ADAM17 protein can cleave IL6R, TNFR1, ACE2, etc.

        Where ADAM17 is highly expressed? 06/25/2021

        ADAM17 is widely expressed in somatic and immune cells

        In addition to Diabetes mellitus and cardiomyopathy-related research, ADAM17 is currently used in the research of which diseases? 01/21/2021

        ADAM17 is also currently being used in studies of breast cancer and gastric cancer, etc.

        Is ADAM17 associated with the EGFR-PI3K-AKT pathway? 10/03/2020

        ADAM17 is an activator that mediates the EGFR-PI3K-AKT pathway.

        Does the package insert for ADAM17 contain detailed information on the handling of the lyophilized powder product? 04/19/2020

        The product manual will contain relevant content on product handling, and you can also consult our technical experts on related issues.

        ADAM17 protein is also involved in recent activities? 12/11/2019

        Yes, ADAM17 protein is involved in this promotion.

        Does ADAM17 mediate the Notch pathway? 10/05/2019

        ADAM17 acts as an activator of Notch pathway by mediating the of cleavage of Notch.

        Does adding His tag have any effect on protein? 04/24/2019

        Addition of His tags usually does not affect the function, properties of the target protein.

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