Recombinant Mouse Adam17 protein, His-tagged
Cat.No. : | Adam17-256M |
Product Overview : | Recombinant Mouse Adam17 protein (Pro18-Asp563), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
- Download
Species : | Mouse |
Source : | HEK293 |
Tag : | His |
ProteinLength : | 546 |
Description : | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), a member of the ADAM protein family of disintegrins and metalloproteases, is also known as TNF-alpha convertase, TNF-alpha-converting enzyme and CD156b, which contains one disintegrin domain and one peptidase M12B domain. ADAM17 can cleave the membrane-bound precursor of TNF-alpha to its mature soluble form. ADAM17 is also responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity) and proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Furthermore, ADAM17 acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation. |
Form : | Lyophilized from 0.22 um filtered solution in 50 mM MES, 150 mM NaCl, pH6.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 63.4 kDa. The protein migrates as 19 kDa and 20 kDa (Propeptide), 55-66 kDa (Mature-ADAM17) and 75-94 kDa (Pro-ADAM17) under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >85% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name | Adam17 |
Official Symbol | Adam17 |
Synonyms | ADAM17; a disintegrin and metallopeptidase domain 17; disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloprotease domain 17; Tace; CD156b |
Gene ID | 11491 |
mRNA Refseq | NM_009615 |
Protein Refseq | NP_033745 |
UniProt ID | Q9Z0F8 |
◆ Recombinant Proteins | ||
RFL15231TF | Recombinant Full Length Torpedo Marmorata 14 Kda Transmembrane Protein Protein, His-Tagged | +Inquiry |
Fbn1-2629R | Recombinant Rat Fbn1 protein, His-tagged | +Inquiry |
CDC42EP1-3123H | Recombinant Human CDC42EP1 Protein, MYC/DDK-tagged | +Inquiry |
ETNPPL-10753Z | Recombinant Zebrafish ETNPPL | +Inquiry |
CYP74A-831M | Recombinant Mouse -ear cress CYP74A protein, His&Myc-tagged | +Inquiry |
|
◆ Native Proteins | ||
Ngf-298M | Active Native Mouse Nerve Growth Factor | +Inquiry |
F10-267B | Active Native Bovine Factor X | +Inquiry |
TPO-702H | Native Human Thyroid Peroxidase | +Inquiry |
IgG-169H | Native Human IgG Fc fragment | +Inquiry |
C-type lectin like protein-040H | Native Hen C-type lectin like protein Protein | +Inquiry |
◆ Cell & Tissue Lysates | ||
DDC-724HCL | Recombinant Human DDC cell lysate | +Inquiry |
GTF2H3-5695HCL | Recombinant Human GTF2H3 293 Cell Lysate | +Inquiry |
FGFRL1-2480MCL | Recombinant Mouse FGFRL1 cell lysate | +Inquiry |
OSBPL1A-3539HCL | Recombinant Human OSBPL1A 293 Cell Lysate | +Inquiry |
PI3-2035HCL | Recombinant Human PI3 cell lysate | +Inquiry |
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Ask a Question for All Adam17 Products
Required fields are marked with *
My Review for All Adam17 Products
Required fields are marked with *
0
Inquiry Basket