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Recombinant Mouse Adam17 protein, His-tagged

Cat.No. : Adam17-256M
Product Overview : Recombinant Mouse Adam17(Pro 18 - Asp 563) fused with His tag at C-terminal was expressed in HEK293.
Source : HEK293
Species : Mouse
Tag : His
Predicted N Terminal : Pro 18,Asp 59 and Arg 215
Form : Lyophilized from 0.22 μm filtered solution in 50 mM MES, 150 mM NaCl, pH6.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass : Has a calculated MW of 63.4 kDa. DTT-reduced Protein migrates as 19 kDa and 20 kDa(Propeptide),55-66 kDa (Mature-ADAM17) and 75-94 kDa(Pro-ADAM17) in SDS-PAGE due to glycosylation.
Protein length : Pro 18 - Asp 563
Endotoxin : Less than 1.0 EU per μg of the Mouse ADAM17 / TACE by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Storage : Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4 centigrade); After reconstitution under sterile conditions for 3 months (-70 centigrade).
Gene Name : Adam17 a disintegrin and metallopeptidase domain 17 [ Mus musculus ]
Official Symbol : Adam17
Synonyms : ADAM17; a disintegrin and metallopeptidase domain 17; disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloprotease domain 17; Tace; CD156b;
Gene ID : 11491
mRNA Refseq : NM_009615
Protein Refseq : NP_033745
MIM :
UniProt ID : Q9Z0F8
Chromosome Location : 12 A1.3; 12 8.3 cM
Pathway : Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Disease, organism-specific biosystem; Notch Signaling Pathway, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, conserved biosystem;
Function : PDZ domain binding; SH3 domain binding; hydrolase activity; integrin binding; interleukin-6 receptor binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; zinc ion binding;

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