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Recombinant Rat Adam17 protein, His & T7-tagged

Cat.No. : Adam17-7115R
Product Overview : Recombinant Rat Adam17 aa. (Leu221~Ser451 (Accession# Q9Z1K9)) fused with N-terminal His & T7 tag was produced in E. coli cells.
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Description : Expression occurs in response to oxygen glucose deprivation, may play a role in inhibition of apoptosis via induction of TNF-alpha release.
Source : E. coli
Species : Rat
Tag : His&T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 29.6kDa
Protein length : Leu221~Ser451
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 5.6.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Adam17 ADAM metallopeptidase domain 17 [ Rattus norvegicus (Norway rat) ]
Official Symbol : Adam17
Synonyms : Adam17; ADAM metallopeptidase domain 17; TACE; disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; TNF-alpha convertase; TNF-alpha-converting enzyme; a disintegrin and metallopeptidase domain 17; a disintegrin and metalloprotease domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)
Gene ID : 57027
mRNA Refseq : NM_020306.2
Protein Refseq : NP_064702.1
UniProt ID : Q9Z1K9

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
04/08/2022

    Cheap price, high quality products, worth buying again

    03/15/2019

      The high quality of the purchased protein helped me to obtain satisfactory experimental results.

      02/26/2019

        Good after-sales service attitude, helped me solve a lot of problems in the experiment.

        Q&As (10)

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        Is ADAM17 protein involved in the renin-angiotensin system? 08/01/2022

        ADAM17 is a negative regulator of the RAS system.

        My research requires high protein purity, can I customize > 90% ADAM17 protein? 06/05/2022

        Yes, we have produced ADAM17 protein of this purity.

        What proteins does ADAM17 cleave? 04/07/2022

        ADAM17 protein can cleave IL6R, TNFR1, ACE2, etc.

        Where ADAM17 is highly expressed? 06/25/2021

        ADAM17 is widely expressed in somatic and immune cells

        In addition to Diabetes mellitus and cardiomyopathy-related research, ADAM17 is currently used in the research of which diseases? 01/21/2021

        ADAM17 is also currently being used in studies of breast cancer and gastric cancer, etc.

        Is ADAM17 associated with the EGFR-PI3K-AKT pathway? 10/03/2020

        ADAM17 is an activator that mediates the EGFR-PI3K-AKT pathway.

        Does the package insert for ADAM17 contain detailed information on the handling of the lyophilized powder product? 04/19/2020

        The product manual will contain relevant content on product handling, and you can also consult our technical experts on related issues.

        ADAM17 protein is also involved in recent activities? 12/11/2019

        Yes, ADAM17 protein is involved in this promotion.

        Does ADAM17 mediate the Notch pathway? 10/05/2019

        ADAM17 acts as an activator of Notch pathway by mediating the of cleavage of Notch.

        Does adding His tag have any effect on protein? 04/24/2019

        Addition of His tags usually does not affect the function, properties of the target protein.

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