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Recombinant Rat ADAM17 Protein, His-tagged

Cat.No. : ADAM17-073R
Product Overview : Recombinant Rat ADAM17 protein with His tag was expressed in HEK293.
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Description : Predicted to enable PDZ domain binding activity; metalloendopeptidase activity involved in amyloid precursor protein catabolic process; and signaling receptor binding activity. Involved in several processes, including regulation of apoptotic process; regulation of signal transduction; and response to antineoplastic agent. Located in several cellular components, including apical part of cell; cell surface; and cytoplasmic vesicle. Biomarker of Alzheimer's disease; congestive heart failure; and thoracic aortic aneurysm. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17).
Source : HEK293
Species : Rat
Tag : His
Form : Lyophilized
Molecular Mass : 63.4 kDa
Protein length : 827
AA Sequence : MRQRLLFLTTLVPFVLAPRPPEEPG SGSHLRLEKLDSLLSDYDILSLSNI QQHSIRKRDLQSATHLETLLTFSAL KRHFKLYLTSSTERFSQNLRVVVVD GKEESEYSVKWQDFFSGHVVGEPDS RVLAHIGDDDVTVRINTDGAEYNIE PLWRFVNDTKDKRMLVYKSEDIKDF SRLQSPKVCGYLNADSEELLPKGLI DREPSEEFVRRVKRRAEPNPLKNTC KLLVVADHRFYKYMGRGEESTTTNY LIELIDRVDDIYRNTSWDNAGFKGY GVQIEQIRILKSPQEVKPGERHFNM AKSFPNEEKDAWDVKMLLEQFSLDI AEEASKVCLAHLFTYQDFDMGTLGL AYVGSPRANSHGGVCPKAYYNPGVK KNIYLNSGLTSTKNYGKTILTKEAD LVTTHELGHNFGAEHDPDGLAECAP NEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSN KVCGNSRVDEGEECDPGIMYLNNDT CCNSDCTLKPGVQCSDRNSPCCKNC QFETAQKKCQEAINATCKGVSYCTG NSSECPPPGDAEDDTVCLDLGKCKA GKCIPFCKREQELESCACADTDNSC KVCCRNLSGPCVPYVDAEQKNLFLR KGKPCTVGFCDMNGKCEKRVQDVIE RFWDFIDQLSINTFGKFLADNIVGS VLVFSLIFWIPFSILVHCVDKKLDK QYESLSLFHHSNIEMLSSMDSASVR IIKPFPAPQTPGRLQALQPAAMMPP VSAAPKLDHQRMDTIQEDPSTDSHV DDDGFEKDPFPNSSAAAKSFEDLTD HPVTRSEKAASFKLQRQSRVDSKET EC
Purity : > 98%
Applications : WB; ELISA; FACS; FC
Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
Storage : At -20 centigrade.
Concentration : 1 mg/mL
Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
Gene Name : Adam17 ADAM metallopeptidase domain 17 [ Rattus norvegicus ]
Official Symbol : ADAM17
Synonyms : ADAM17; ADAM metallopeptidase domain 17; disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; a disintegrin and metalloprotease domain 17; a disintegrin and metallopeptidase domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); TACE;
Gene ID : 57027
mRNA Refseq : NM_020306
Protein Refseq : NP_064702
UniProt ID : Q9Z1K9

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
04/08/2022

    Cheap price, high quality products, worth buying again

    03/15/2019

      The high quality of the purchased protein helped me to obtain satisfactory experimental results.

      02/26/2019

        Good after-sales service attitude, helped me solve a lot of problems in the experiment.

        Q&As (10)

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        Is ADAM17 protein involved in the renin-angiotensin system? 08/01/2022

        ADAM17 is a negative regulator of the RAS system.

        My research requires high protein purity, can I customize > 90% ADAM17 protein? 06/05/2022

        Yes, we have produced ADAM17 protein of this purity.

        What proteins does ADAM17 cleave? 04/07/2022

        ADAM17 protein can cleave IL6R, TNFR1, ACE2, etc.

        Where ADAM17 is highly expressed? 06/25/2021

        ADAM17 is widely expressed in somatic and immune cells

        In addition to Diabetes mellitus and cardiomyopathy-related research, ADAM17 is currently used in the research of which diseases? 01/21/2021

        ADAM17 is also currently being used in studies of breast cancer and gastric cancer, etc.

        Is ADAM17 associated with the EGFR-PI3K-AKT pathway? 10/03/2020

        ADAM17 is an activator that mediates the EGFR-PI3K-AKT pathway.

        Does the package insert for ADAM17 contain detailed information on the handling of the lyophilized powder product? 04/19/2020

        The product manual will contain relevant content on product handling, and you can also consult our technical experts on related issues.

        ADAM17 protein is also involved in recent activities? 12/11/2019

        Yes, ADAM17 protein is involved in this promotion.

        Does ADAM17 mediate the Notch pathway? 10/05/2019

        ADAM17 acts as an activator of Notch pathway by mediating the of cleavage of Notch.

        Does adding His tag have any effect on protein? 04/24/2019

        Addition of His tags usually does not affect the function, properties of the target protein.

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