| Description : |
Predicted to enable PDZ domain binding activity; metalloendopeptidase activity involved in amyloid precursor protein catabolic process; and signaling receptor binding activity. Involved in several processes, including regulation of apoptotic process; regulation of signal transduction; and response to antineoplastic agent. Located in several cellular components, including apical part of cell; cell surface; and cytoplasmic vesicle. Biomarker of Alzheimer's disease; congestive heart failure; and thoracic aortic aneurysm. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17). |
| Source : |
HEK293 |
| Species : |
Rat |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
63.4 kDa |
| Protein Length : |
827 |
| AA Sequence : |
MRQRLLFLTTLVPFVLAPRPPEEPG SGSHLRLEKLDSLLSDYDILSLSNI QQHSIRKRDLQSATHLETLLTFSAL KRHFKLYLTSSTERFSQNLRVVVVD GKEESEYSVKWQDFFSGHVVGEPDS RVLAHIGDDDVTVRINTDGAEYNIE PLWRFVNDTKDKRMLVYKSEDIKDF SRLQSPKVCGYLNADSEELLPKGLI DREPSEEFVRRVKRRAEPNPLKNTC KLLVVADHRFYKYMGRGEESTTTNY LIELIDRVDDIYRNTSWDNAGFKGY GVQIEQIRILKSPQEVKPGERHFNM AKSFPNEEKDAWDVKMLLEQFSLDI AEEASKVCLAHLFTYQDFDMGTLGL AYVGSPRANSHGGVCPKAYYNPGVK KNIYLNSGLTSTKNYGKTILTKEAD LVTTHELGHNFGAEHDPDGLAECAP NEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSN KVCGNSRVDEGEECDPGIMYLNNDT CCNSDCTLKPGVQCSDRNSPCCKNC QFETAQKKCQEAINATCKGVSYCTG NSSECPPPGDAEDDTVCLDLGKCKA GKCIPFCKREQELESCACADTDNSC KVCCRNLSGPCVPYVDAEQKNLFLR KGKPCTVGFCDMNGKCEKRVQDVIE RFWDFIDQLSINTFGKFLADNIVGS VLVFSLIFWIPFSILVHCVDKKLDK QYESLSLFHHSNIEMLSSMDSASVR IIKPFPAPQTPGRLQALQPAAMMPP VSAAPKLDHQRMDTIQEDPSTDSHV DDDGFEKDPFPNSSAAAKSFEDLTD HPVTRSEKAASFKLQRQSRVDSKET EC |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
