Recombinant Rat ADAM17 Protein, His-tagged
Cat.No. : | ADAM17-073R |
Product Overview : | Recombinant Rat ADAM17 protein with His tag was expressed in HEK293. |
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Description : | Predicted to enable PDZ domain binding activity; metalloendopeptidase activity involved in amyloid precursor protein catabolic process; and signaling receptor binding activity. Involved in several processes, including regulation of apoptotic process; regulation of signal transduction; and response to antineoplastic agent. Located in several cellular components, including apical part of cell; cell surface; and cytoplasmic vesicle. Biomarker of Alzheimer's disease; congestive heart failure; and thoracic aortic aneurysm. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17). |
Source : | HEK293 |
Species : | Rat |
Tag : | His |
Form : | Lyophilized |
Molecular Mass : | 63.4 kDa |
Protein length : | 827 |
AA Sequence : | MRQRLLFLTTLVPFVLAPRPPEEPG SGSHLRLEKLDSLLSDYDILSLSNI QQHSIRKRDLQSATHLETLLTFSAL KRHFKLYLTSSTERFSQNLRVVVVD GKEESEYSVKWQDFFSGHVVGEPDS RVLAHIGDDDVTVRINTDGAEYNIE PLWRFVNDTKDKRMLVYKSEDIKDF SRLQSPKVCGYLNADSEELLPKGLI DREPSEEFVRRVKRRAEPNPLKNTC KLLVVADHRFYKYMGRGEESTTTNY LIELIDRVDDIYRNTSWDNAGFKGY GVQIEQIRILKSPQEVKPGERHFNM AKSFPNEEKDAWDVKMLLEQFSLDI AEEASKVCLAHLFTYQDFDMGTLGL AYVGSPRANSHGGVCPKAYYNPGVK KNIYLNSGLTSTKNYGKTILTKEAD LVTTHELGHNFGAEHDPDGLAECAP NEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSN KVCGNSRVDEGEECDPGIMYLNNDT CCNSDCTLKPGVQCSDRNSPCCKNC QFETAQKKCQEAINATCKGVSYCTG NSSECPPPGDAEDDTVCLDLGKCKA GKCIPFCKREQELESCACADTDNSC KVCCRNLSGPCVPYVDAEQKNLFLR KGKPCTVGFCDMNGKCEKRVQDVIE RFWDFIDQLSINTFGKFLADNIVGS VLVFSLIFWIPFSILVHCVDKKLDK QYESLSLFHHSNIEMLSSMDSASVR IIKPFPAPQTPGRLQALQPAAMMPP VSAAPKLDHQRMDTIQEDPSTDSHV DDDGFEKDPFPNSSAAAKSFEDLTD HPVTRSEKAASFKLQRQSRVDSKET EC |
Purity : | > 98% |
Applications : | WB; ELISA; FACS; FC |
Stability : | This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
Storage : | At -20 centigrade. |
Concentration : | 1 mg/mL |
Storage Buffer : | PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
Reconstitution : | Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
Gene Name : | Adam17 ADAM metallopeptidase domain 17 [ Rattus norvegicus ] |
Official Symbol : | ADAM17 |
Synonyms : | ADAM17; ADAM metallopeptidase domain 17; disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; a disintegrin and metalloprotease domain 17; a disintegrin and metallopeptidase domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); TACE; |
Gene ID : | 57027 |
mRNA Refseq : | NM_020306 |
Protein Refseq : | NP_064702 |
UniProt ID : | Q9Z1K9 |
Products Types
◆ Recombinant Protein | ||
ADAM17-085M | Recombinant Mouse ADAM17 Protein, His-tagged | +Inquiry |
Adam17-308M | Recombinant Mouse Adam17 Protein, His (Fc)-Avi-tagged | +Inquiry |
Adam17-8788R | Active Recombinant Rat Adam17 protein(Met1-Asp563), His-tagged | +Inquiry |
ADAM17-157R | Recombinant Rat ADAM17 Protein, His (Fc)-Avi-tagged | +Inquiry |
ADAM17-593H | Active Recombinant Human ADAM17 | +Inquiry |
◆ Lysates | ||
ADAM17-1198RCL | Recombinant Rat ADAM17 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0049 | ADAM17 Inhibitor Screening Assay Kit | +Inquiry |
Kit-0048 | ADAM17 fluorometric drug discovery Kit | +Inquiry |
Related Gene
Not For Human Consumption!
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Customer Reviews (3)
Write a reviewCheap price, high quality products, worth buying again
The high quality of the purchased protein helped me to obtain satisfactory experimental results.
Good after-sales service attitude, helped me solve a lot of problems in the experiment.
Q&As (10)
Ask a questionADAM17 is a negative regulator of the RAS system.
Yes, we have produced ADAM17 protein of this purity.
ADAM17 protein can cleave IL6R, TNFR1, ACE2, etc.
ADAM17 is widely expressed in somatic and immune cells
ADAM17 is also currently being used in studies of breast cancer and gastric cancer, etc.
ADAM17 is an activator that mediates the EGFR-PI3K-AKT pathway.
The product manual will contain relevant content on product handling, and you can also consult our technical experts on related issues.
Yes, ADAM17 protein is involved in this promotion.
ADAM17 acts as an activator of Notch pathway by mediating the of cleavage of Notch.
Addition of His tags usually does not affect the function, properties of the target protein.
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