AXL

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AXL

Official Full Name AXL receptor tyrosine kinase
Background The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Synonyms AXL; AXL receptor tyrosine kinase; UFO; JTK11; tyrosine-protein kinase receptor UFO; AXL oncogene; AXL transforming sequence/gene;
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • NS0
    • NSO
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • His
    • Fc
    • Fc Chimera
    • Flag
    • GST
    • T7
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AXL-10086H Recombinant Human AXL, GST-tagged E.coli GST
    Human AXL-1049H Recombinant Human AXL protein, GST-tagged Wheat Germ GST
    Human AXL-190H Recombinant Human AXL, Fc Chimera NS0 Fc Chimera
    Human AXL-202H Recombinant Human AXL (R499C), GST-tagged Sf9 Insect Cell GST
    Human AXL-2281HCL Recombinant Human AXL cell lysate Human Cell N/A
    Human AXL-249H Recombinant Human AXL Receptor Tyrosine Kinase, His-tagged, Active Sf9 Insect Cell His
    Human AXL-36H Recombinant Human AXL protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human AXL-379H Recombinant Human AXL protein, GST-tagged Insect Cell GST
    Human AXL-537H Recombinant Human AXL, Fc-tagged, Biotinylated Human Cell Fc
    Human AXL-538H Recombinant Human AXL, Fc-tagged Human Cell Fc
    Human AXL-539H Recombinant Human AXL Receptor Tyrosine Kinase, GST-tagged Sf9 Insect Cell GST
    Human AXL-5894H Recombinant Human AXL Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human AXL-769H Recombinant Human AXL, His tagged Human Cell His
    Human AXL-770H Recombinant Human AXL protein, His-tagged HEK293 His
    Human AXL-920H Recombinant Human AXL Protein, DDK/His-tagged HEK293 DDK/His
    Human AXL-921H Recombinant Human AXL Protein, DDK/His-tagged HEK293 DDK/His
    Mouse Axl-132M Recombinant Mouse Axl, Fc-His tagged Human Cell Fc/His
    Mouse AXL-2476MCL Recombinant Mouse AXL cell lysate Human Cell N/A
    Mouse Axl-499M Recombinant Mouse AXL Receptor Tyrosine Kinase NSO N/A
    Mouse Axl-626M Recombinant Mouse Axl, His tagged Human Cell His
    Rat Axl-1820R Recombinant Rat Axl protein, His & T7-tagged E.coli His/T7

    AXL involved in several pathways and played different roles in them. We selected most pathways AXL participated on our site, such as Signal Transduction, Signaling by VEGF, VEGFA-VEGFR2 Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AXL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signal Transduction VIP; CCRL2; ADH8B; FAM13B; MKS1; ARAP1; LPAR2A; STRAP; MDKA; FSTL1
    Signaling by VEGF NRP2A; NRP2; DSCAMA; JUPA; AXL; SHB; NRP2B
    VEGFA-VEGFR2 Pathway DSCAMA; JUPA; AXL

    AXL has several biochemical functions, for example, ATP binding, phosphatidylserine binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AXL itself. We selected most functions AXL had, and list some proteins which have the same functions with AXL. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding NSFB; PGS1; MCM2; FBXO18; KIF12; HELLS; ATP8B1; MSH4; FYN; MAP2K2A
    phosphatidylserine binding OSBPL10; MARK1; FCHO2; SDPR; THBS1; SYT4; TRIM72; AXL; GAS6; PLCD1
    protein binding TMEM41A; ATF2; PPP3CC; CALM3; CEP152; GLS; DAPK3; SLC38A2; GYG1; GLYCTK
    protein heterodimerization activity HIST2H3C; POLE3; TCF4; CENPA; NKX2-5; BCL2A1; CLCN3; CEBPG; OSTB; P2RY1
    protein tyrosine kinase activity EGFRA; JAK3; DYRK3; TESK2; FES; MAP2K5; PTK2AA; JAK1; CAMKK2; NEK1
    transmembrane receptor protein tyrosine kinase activity NTRK2B; EPHB4A; ERBB4A; DDR1; TIE1; KDRL; ROS1; EPHA2; TRIM27; EPHA4A
    virus receptor activity SELPLG; HLA-DRB1; SIVA1; XPR1; CD80; CR2; HSPA1A; CLEC5A; HYAL2; HAVCR1

    AXL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AXL here. Most of them are supplied by our site. Hope this information will be useful for your research of AXL.

    EGFR; PLCG1; PIK3R1; GRB2; GAS6; abl-tide

    Yu, Z; Li, XC; et al. 3D-QSAR modeling and molecular docking study on Mer kinase inhibitors of pyridine-substituted pyrimidines. MOLECULAR DIVERSITY 19:135-147(2015).
    Albert, R; Kristof, E; et al. Triamcinolone regulated apopto-phagocytic gene expression patterns in the clearance of dying retinal pigment epithelial cells. A key role of Mertk in the enhanced phagocytosis. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1850:435-446(2015).

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