CCL2 Protein, chemokine (C-C motif) ligand 2

CCL2

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CCL2

Official Full Name chemokine (C-C motif) ligand 2
Background This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]
Synonyms CCL2; chemokine (C-C motif) ligand 2; HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30; C-C motif chemokine 2; small-inducible cytokine A2; monocyte secretory protein JE; monocyte chemotactic protein 1; monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; small inducible cytokine subfamily A (Cys-Cys), member 2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je);
    • Species :
    • Bovine
    • Canine
    • Cynomolgus Monkey
    • Dog
    • Equine
    • Guinea pig
    • Horse
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus macaque
    • Rhesus monkey
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cynomolgus Monkey CCL2-01C Recombinant Cynomolgus Monkey CCL2 Protein Yeast
    Mouse Ccl2-130M Recombinant Mouse Ccl2 Protein E.coli
    Human CCL2-0621H Recombinant Human CCL2 Protein E.coli N/A
    Human CCL2-0622H Recombinant Human CCL2 Protein, GST-Tagged Wheat Germ GST
    Human CCL2-108H Human CCL2 N/A
    Human CCL2-1188H Recombinant Human Monocyte Chemoattractant Protein 1 E.coli N/A
    Human CCL2-124H Recombinant Human Chemokine (C-C Motif) Ligand 2 NS0 N/A
    Human CCL2-125H Human Monocyte Chemoattractant Protein-1(rDNA derived) Reference standard N/A
    Human CCL2-130H Recombinant Human CCL2, Fc-tagged CHO Fc
    Human CCL2-1680M Recombinant Mouse CCL2, HIgG1 Fc-tagged CHO Fc
    Human CCL2-189H Recombinant Human CCL2 Protein, His-tagged Yeast His
    Human CCL2-275H Recombinant Human CCL2, StrepII-tagged Human Cell Strep II
    Human CCL2-281H Recombinant Human CCL2 protein E.coli N/A
    Human CCL2-2890H Recombinant Human CCL2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CCL2-381H Recombinant Human CCL2, MIgG2a Fc-tagged CHO Fc
    Human CCL2-63H Recombinant Human Chemokine (C-C motif) Ligand 2, His-tagged E.coli His
    Human CCL2-78H Recombinant Human CCL2 HEK293 N/A
    Mouse CCL2-001MCL Recombinant Mouse CCL2 cell lysate Insect Cell N/A
    Mouse CCL2-1679M Recombinant Mouse CCL2, MIgG2a Fc-tagged CHO Fc
    Mouse Ccl2-282M Recombinant Mouse Chemokine (C-C motif) Ligand 2 E.coli N/A
    Mouse Ccl2-482M Recombinant Mouse Ccl2, His-tagged Insect Cell His
    Mouse CCL2-559M Recombinant Mouse chemokine (C-C motif) ligand 2, His-tagged E.coli His
    Mouse Ccl2-687M Recombinant Mouse Ccl2 protein, His-tagged E.coli His
    Rat CCL2-1211R Recombinant Rat CCL2 Protein Mammalian Cell His
    Rat CCL2-2894R Recombinant Rat CCL2 Protein E.coli N/A
    Rat Ccl2-469R Recombinant Rat Chemokine (C-C motif) Ligand 2 NS0 N/A
    Rat Ccl2-55R Recombinant Rat Chemokine (C-C Motif) Ligand 2 E.coli N/A
    Rat Ccl2-689R Recombinant Rat Ccl2 protein, His-tagged E.coli His
    Cynomolgus Monkey CCL2-372C Recombinant Cynomolgus CCL2 Protein, His-tagged Mammalian Cell His
    Rhesus macaque CCL2-185R Recombinant Rhesus macaque CCL2 protein, GST-tagged E.coli GST
    Rhesus Macaque CCL2-683R Recombinant Rhesus monkey CCL2 Protein, His-tagged Mammalian Cell His
    Rhesus monkey CCL2-691R Recombinant Rhesus monkey CCL2 protein, His-tagged E.coli His
    Canine CCL2-406C Recombinant Canine Chemokine (C-C motif) Ligand 2 E.coli N/A
    Canine CCL2-44C Recombinant Canine CCL2 (MCP-1) Yeast N/A
    Dog CCL2-683D Recombinant Dog CCL2 protein, His & GST-tagged E.coli His/GST
    Bovine CCL2-131B Recombinant Bovine Chemokine (C-C motif) Ligand 2 Yeast N/A
    Rabbit Ccl2-283R Recombinant Rabbit Chemokine (C-C Motif) Ligand 2 E.coli N/A
    Rabbit CCL2-690R Recombinant Rabbit CCL2 protein, His-tagged E.coli His
    Equine CCL2-139E Recombinant Equine Chemokine (C-C motif) Ligand 2 Yeast N/A
    Pig CCL2-144S Recombinant Swine Chemokine (C-C motif) Ligand 2 Yeast N/A
    Equine CCL2-21E Recombinant Equine CCL2 Yeast N/A
    Horse CCL2-684H Recombinant Horse CCL2 protein, His & T7-tagged E.coli His/T7
    Guinea pig Ccl2-685G Recombinant Guinea pig Ccl2 protein, His & T7-tagged E.coli His/T7
    Pig CCL2-688P Recombinant Pig CCL2 protein, His & GST-tagged E.coli His/GST

    CCL2 involved in several pathways and played different roles in them. We selected most pathways CCL2 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CRFB16; CXCL10; IL2RGA; GM2002; IL24; PDGFB; ACVR1; IL28RA; IFNK; IL1R1
    Chemokine signaling pathway RAP1A; KRAS; Ccl27a; VAV2; GNGT1; CCL5; GM2506; CXCL2; STAT5B; PIK3R2
    NOD-like receptor signaling pathway MAP3K7; MAPK12; MAPK11; PSTPIP1; PSTPIP1A; NFKBIAB; NLRP3; IL6; IKBKG; TAB2
    TNF signaling pathway MAPK10; RPS6KA5; CX3CL1; DNM1L; MAP2K1; VEGFC; FADD; CREB3L2; PIK3CD; NFKBIA
    Chagas disease (American trypanosomiasis) SERPINE1; GNA11; IKBKG; IKBKB; GNAI1; TLR9; IL12A; MAPK8; TICAM1; CD247
    Malaria HBA1; KLRB1; HGF; SDC2; THBS3; HBB-B2; IFNG; THBS2; TGFB2; TLR2
    Influenza A TNFRSF10B; HLA-DRB5; IRF7; RSAD2; TNF; XPO1; HLA-DQA1; PRSS3; IFNA1; NFKB1
    Herpes simplex infection NFKB1; Ccl12; BLA; OAS2; TTC6; UBE2R2; Hc; IFNB; H2-AA; IRF7
    Rheumatoid arthritis H2-AA; HLA-DQA2; ATP6AP1; Il23a; ACP5; HLA-DRB3; IL6; ATP6V1C1; ATP6V1E1; TNFSF13

    CCL2 has several biochemical functions, for example, CCR2 chemokine receptor binding, chemokine activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL2 itself. We selected most functions CCL2 had, and list some proteins which have the same functions with CCL2. You can find most of the proteins on our site.

    Function Related Protein
    CCR2 chemokine receptor binding Ccl12; CCL2; CCL7
    chemokine activity CKLF; CCL35.1; CCL23; CXCL32B.1; CCL15; CCL33.2; CCL19B; PF4V1; CCL44; CCL16
    heparin binding NOV; LPA; FSTL1; EPYC; SOST; SLIT1; MMP7; LAMC2; PTPRF; SMOC2
    protein kinase activity MAP4K3; CCND1; HIPK3A; EPHB3A; VRK1; PRKAA2; NPRL2; FYNB; NTRK2B; STK3
    receptor binding TNFSF13B; TIGIT; ICOSLG; IFNL3; NPFFL; CD58; LBP; PLA2G1B; PTPRD; F2

    CCL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL2.

    GAMMAHV.M3

    Driss, V; Quesnel, B; et al. Monocyte chemoattractant protein 1 (MCP-1/CCL2) contributes to thymus atrophy in acute myeloid leukemia. EUROPEAN JOURNAL OF IMMUNOLOGY 45:396-406(2015).
    Martirosyan, A; Petrek, M; et al. Differential Regulation of Proinflammatory Mediators following LPS- and ATP-Induced Activation of Monocytes from Patients with Antiphospholipid Syndrome. BIOMED RESEARCH INTERNATIONAL :-(2015).

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