ccl22
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  • Official Full Name
  • CCL22 chemokine (C-C motif) ligand 22
  • Background
  • This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology.
  • Synonyms
  • CCL22; chemokine (C-C motif) ligand 22; MDC; ABCD-1; SCYA22; STCP-1; DC/B-CK; MGC34554; A-152E5.1; C-C motif chemokine 22; MDC(1-69); OTTHUMP00000164658; CC chemokine STCP-1; macrophage-derived chemokine; small inducible cytokine A22; small-inducible cytokine A22; stimulated T cell chemotactic protein 1; stimulated T-cell chemotactic protein 1; small inducible cytokine subfamily A (Cys-Cys), member 22
Cat.#:CCL22-311HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL22 Protein, His-tagged
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Cat.#:CCL22-0627HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCL22 Protein, GST-Tagged
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Cat.#:CCL22-2884MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse CCL22 Protein
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Cat.#:CCL22-2887MTag:
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse CCL22 Protein
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Cat.#:CCL22-1874HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-C motif) Ligand 22
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Cat.#:CCL22-136HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CCL22, Fc-tagged
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Cat.#:CCL22-18HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CCL22, HIgG1 Fc-tagged
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Cat.#:CCL22-1900HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CCL22, MIgG2a Fc-tagged
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Cat.#:CCL22-29602THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL22
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Cat.#:CCL22-29753THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL22, His-tagged
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Cat.#:CCL22-3862HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-C motif) Ligand 22, HIgG1 Fc-tagged, mutant
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Cat.#:CCL22-702HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL22 protein, His & GST-tagged
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Cat.#:CCL22-897HTag:His
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human CCL22 Protein, His-tagged
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Cat.#:CCL22-1678MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse CCL22, MIgG2a Fc-tagged
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Cat.#:CCL22-3861MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Chemokine (C-C motif) Ligand 22, MIgG2a Fc-tagged, mutant
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Cat.#:CCL22-978MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse CCL22 Protein, His-tagged
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Cat.#:Ccl22-637RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ccl22
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Cat.#:Ccl22-703RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ccl22 protein, His & GST-tagged
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Cat.#:CCL22-701DTag:His/GST
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog CCL22 protein, His & GST-tagged
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Cat.#:CCL22-700CTag:His/GST
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle CCL22 protein, His & GST-tagged
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Cat.#:CCL22-112HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-C Motif) Ligand 22, His-tagged
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Cat.#:CCL22-67HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL22, 69aa
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Cat.#:Ccl22-91MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chemokine (C-C Motif) Ligand 22
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Cat.#:CCL22-7728HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CCL22 293 Cell Lysate
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Involved Pathway

CCL22 involved in several pathways and played different roles in them. We selected most pathways CCL22 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CXCL2; IL8L2; IL12BA; IFNA21; GM13306; CCL5; KITLG; CSF1R; FLT1; PDGFAB
Chemokine signaling pathway
VAV1; JAK2; GNG5; CXCL8; GNG13; BCAR1; CXCR4; WASL; PIK3CA; ITK

Protein Function

CCL22 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL22 itself. We selected most functions CCL22 had, and list some proteins which have the same functions with CCL22. You can find most of the proteins on our site.
Function
Related Protein
Function CCR chemokine receptor binding
Related Protein CCL3L3; CCL24; CXCL32B.1; CCL17; CCL3L1; CCL21; CCL38A.5; CCL14; CCL26; CCL11
Function chemokine activity
Related Protein CXCL19; CCL19A.1; CCL33.3; CXCL11; CXCL9; CCL27; Ccl21c; CCL3L1; CCL38A.4; CXCL12A

Interacting Protein

CCL22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL22 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL22.
DPP4; CRYAB; GCLC; HERC3

CCL22 Related Articles

Yoshie, O; Matsushima, K; et al. CCR4 and its ligands: from bench to bedside. INTERNATIONAL IMMUNOLOGY 27:11-20(2015).
Hernandez-Bedolla, MA; Carretero-Ortega, J; et al. Chemotactic and proangiogenic role of calcium sensing receptor is linked to secretion of multiple cytokines and growth factors in breast cancer MDA-MB-231 cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1853:166-182(2015).

CCL22 Related Gene Family

Chemokines Cytokines