CCL22
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Official Full Name
CCL22 chemokine (C-C motif) ligand 22
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Overview
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. -
Synonyms
CCL22; chemokine (C-C motif) ligand 22; MDC; ABCD-1; SCYA22; STCP-1; DC/B-CK; MGC34554; A-152E5.1; C-C motif chemokine 22; MDC(1-69); OTTHUMP00000164658; CC chemokine STCP-1; macrophage-derived chemokine; small inducible cytokine A22; small-inducible cytokine A22; stimulated T cell chemotactic protein 1; stimulated T-cell chemotactic protein 1; small inducible cytokine subfamily A (Cys-Cys), member 22;
- Recombinant Proteins
- Cell & Tissue Lysates
- Cattle
- Dog
- Human
- Mouse
- Pig
- Rat
- CHO
- E.coli
- HEK293
- HEK293T
- Human Cells
- In Vitro Cell Free System
- Wheat Germ
- Biotin
- Fc
- GST
- His
- His|GST
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CCL22 Related Articles
- CCL22 Related Gene Family
- CCL22 Related Research Area
CCL22 involved in several pathways and played different roles in them. We selected most pathways CCL22 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CCL19B;BMPR1BB;IL18RAP;IL10;IL23R;PDGFB;KITB;IL9R;CCR5 |
| Chemokine signaling pathway | IL-8;CCL4L1;GNAI1;SOS1;IKBKG;GNB2;XCR1;CCR3;PLCB1 |
CCL22 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL22 itself. We selected most functions CCL22 had, and list some proteins which have the same functions with CCL22. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CCR chemokine receptor binding | CCL34A.4;CCL35.1;CCL13;CXCL32B.1;CCL1;CCL25B;CCL38A.4;CCL19B;CCL16 |
| chemokine activity | CCL34B.9;CCL21B;CCL20A.3;CCL7;CXCL2;CCL19;CXCL5;PF4;CCL34B.1 |
CCL22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL22 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL22.
DPP4; CRYAB; GCLC; HERC3
- Q&As
- Reviews
Q&As (6)
Ask a questionThe expression of CCL22 gene is regulated by a variety of signaling pathways, including inflammatory factor-mediated signaling pathways, cytokine-mediated signaling pathways, and transcription factors.
Studies have shown that by interfering with the interaction of the CCL22 protein and its receptor CCR4, tumor growth, improve inflammatory response, and regulate autoimmune diseases can be inhibited. These findings provide potential application value for the development of corresponding therapeutic strategies.
A number of inhibitors or antagonists that interact with CCL22 proteins have been developed that block the binding of CCL22 to its receptor CCR4, thereby interfering with its biological function.
The mechanism of action of CCL22 protein in specific diseases can be studied through cell culture experiments, animal models, clinical samples, and related biochemical techniques.
There are complex interactions between CCL22 proteins and other chemokines. They may influence the migration and localization of immune cells by competing for receptors, mutual regulation of expression, etc.
Some studies have shown that in tumor immunotherapy, inhibiting the expression of CCL22 or interfering with its interaction with CCR4 can enhance the effect of immunotherapy and improve the survival rate of patients.
Customer Reviews (3)
Write a reviewThe catalytic activity of CCL22 is very strong, which can significantly improve the selectivity and yield of chemical reactions, and has high application value.
This repeatability of CCL22 is very good, which can ensure the safety of the experiment and avoid unnecessary risks.
CCL22 were well suited for our research needs due to their simple storage conditions and long-term preservation.
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