CCL3

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CCL3

Official Full Name chemokine (C-C motif) ligand 3
Background CCL3, also known as Macrophage inflammatory protein-1α (MIP-1α), is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes (Wolpe et al., 1988). Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha and beta.
Synonyms Ccl3; chemokine (C-C motif) ligand 3; Mip1a; Scya3; G0S19-1; AI323804; MIP1-(a); LD78alpha; MIP-1alpha; MIP1-alpha; C-C motif chemokine 3; TY-5; L2G25B; MIP1 (a); SIS-alpha; MIP-1 alpha; MIP-1-alpha; OTTMUSP00000000942; small inducible cytokine A3; small-inducible cytokine A3; heparin-binding chemotaxis protein; macrophage inflammatory protein-1alpha; macrophage inflammatory protein 1-alpha
    • Species :
    • Cotton Rat
    • Dog
    • Equine
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Wheat Germ
    • yeast
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Ccl3-132M Recombinant Mouse Ccl3 Protein E.coli
    Mouse Ccl3-2037M Recombinant Mouse Ccl3 Protein E. coli
    Human CCL3-4453H Recombinant Human CCL3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Ccl3-7337M Recombinant Mouse Ccl3 Protein, His-tagged E.coli His
    Human CCL3-0636H Recombinant Human CCL3 Protein E.coli N/A
    Human CCL3-0637H Recombinant Human CCL3 Protein, GST-Tagged Wheat Germ GST
    Human CCL3-109H Human CCL3 N/A
    Human CCL3-119H Human Macrophage Inflammatory Protein-1 alpha (rDNA derived) Reference standard N/A
    Human CCL3-156H Recombinant Human Chemokine (C-C Motif) Ligand 3 Sf21 Insect Cell N/A
    Human CCL3-15H Recombinant Human CCL3 yeast N/A
    Human CCL3-169H Recombinant Human Chemokine (C-C motif) Ligand 3, His-tagged E.coli His
    Human CCL3-246H Recombinant Human CCL3, His-tagged Yeast His
    Human CCL3-276H Recombinant Human CCL3, StrepII-tagged Human Cell Strep II
    Human CCL3-291H Recombinant Human CCL3 protein E.coli N/A
    Human CCL3-29859TH Recombinant Human CCL3, His-tagged E.coli His
    Human CCL3-363H Recombinant Human Chemokine (C-C motif) Ligand 3 Insect Cell N/A
    Human CCL3-475H Recombinant Human CCL3 protein, His-tagged HEK293F His
    Human CCL3-705H Recombinant Human CCL3 protein, His & GST-tagged E.coli His/GST
    Human CCL3-7723HCL Recombinant Human CCL3 293 Cell Lysate HEK293 N/A
    Human CCL3-79H Recombinant Human Chemokine (C-C motif) Ligand 3 HEK293 N/A
    Mouse Ccl3-14M Recombinant Mouse Ccl3 yeast N/A
    Mouse Ccl3-292M Recombinant Mouse Ccl3 protein E.coli N/A
    Mouse CCL3-2975M Recombinant Mouse CCL3 Protein Mammalian Cell His
    Mouse Ccl3-2977M Recombinant Mouse Ccl3 Protein E.coli N/A
    Mouse Ccl3-706M Recombinant Mouse Ccl3 protein, His & GST-tagged E.coli His/GST
    Mouse Ccl3-7197M Recombinant Mouse Chemokine (C-C motif) Ligand 3, His-tagged E.coli His
    Mouse Ccl3-8705M Recombinant Mouse Ccl3, None tagged E.coli N/A
    Rat CCL3-1213R Recombinant Rat CCL3 Protein Mammalian Cell His
    Rat Ccl3-544R Recombinant Rat Ccl3 E.coli N/A
    Rat Ccl3-56R Recombinant Rat Ccl3 protein E.coli N/A
    Rat Ccl3-707R Recombinant Rat Ccl3 protein, His & GST-tagged E.coli His/GST
    Rhesus Macaque CCL3-691R Recombinant Rhesus monkey CCL3 Protein, His-tagged Mammalian Cell His
    Dog CCL3-704D Recombinant Dog CCL3 protein, His & GST-tagged E.coli His/GST
    Equine CCL3-140E Recombinant Equine Chemokine (C-C motif) Ligand 3 Yeast N/A
    Cotton Rat Ccl3-394C Recombinant Cotton Rat Ccl3 E.coli N/A

    CCL3 involved in several pathways and played different roles in them. We selected most pathways CCL3 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction TNFRSF10D; TNFRSF14; IL24; PRLRA; CRLF2; IFNA1; TNFRSF17; TNFRSF11A; CCL3L3; THPO
    Chemokine signaling pathway CCL25; CCL3L3; XCL2; CXCL13; CXCR6; PRKACB; CCL2; ARRB1; ROCK1; CXCL6
    Toll-like receptor signaling pathway CCL5; Ifna11; RELA; TRAF6; IFNAR1; IFNA14; TLR1LB; IFNPHI1; PIK3CA; MAPK12A
    Salmonella infection LBP; MAPK11; RHOG; RHOGB; RHOGC; ACTG1; MAPK12; RAB7B; RAC1A; MYD88
    Chagas disease (American trypanosomiasis) MAPK8; CD3D; PIK3R2; MAPK10; CCL5; PLCB1; GNAI3; CFLAR; IFNG; AKT2
    Rheumatoid arthritis Il23a; Il12b; ATP6V1A; IL23; ITGB2L; CXCL1; ACP5; ATP6V0A2; Ctsl; TGFB3; CD80

    CCL3 has several biochemical functions, for example, CCR1 chemokine receptor binding, CCR5 chemokine receptor binding, calcium-dependent protein kinase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL3 itself. We selected most functions CCL3 had, and list some proteins which have the same functions with CCL3. You can find most of the proteins on our site.

    Function Related Protein
    CCR1 chemokine receptor binding CCL3; CCL7; CCL4; CCL23; CREB3; CCL5
    CCR5 chemokine receptor binding CCL4; STAT3; CCL3; CCL5; JAK1; CNIH4
    calcium-dependent protein kinase C activity CCL3; PRKCA; PRKCG; ALPK2
    chemoattractant activity SAA1; CXCL12; FIGF; MIF; CXCL12A; FGF7; SAA4; VEGFA; NTF3; PDGFB
    chemokine activity CCL39.1; CXCL20; CXCL12; CCL11; CXCL5; CXCL18B; CCL35.2; CXCL1; CCL26; CCL13
    identical protein binding BNIP3L; CBX3; SCUBE1; MAP1S; PSMA7; SEPT7; CEP57L1; ROBO2; PSME3; GBP1
    kinase activity INSRA; AKT3A; ITPK1A; CDK5R1B; CKBB; TPK1; CKMB; PRKRIRA; Fert2; PLAUB
    phospholipase activator activity ARHGAP6; APOC2; CCL5; GM2A; PDPK1; CCL8; CCL3
    protein binding DNMT3B; YIF1A; CHMP2B; ITGA5; ALAS1; KCND2; AMOTL2A; VPS37A; C4BPA; U2AF2
    protein kinase activity GUCY2F; CLK2A; CDK17; CSNK2A2A; PRKCHB; MAPK12B; KDRL; EPHB4A; TRIM24; ULK1A

    CCL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL3.

    IDE

    Suviolahti, E; Ge, SL; et al. Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection. TRANSPLANT IMMUNOLOGY 32:9-17(2015).
    Gouwy, M; De Buck, M; et al. Serum amyloid A chemoattracts immature dendritic cells and indirectly provokes monocyte chemotaxis by induction of cooperating CC and CXC chemokines. EUROPEAN JOURNAL OF IMMUNOLOGY 45:101-112(2015).

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