ccl3
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  • Official Full Name
  • chemokine (C-C motif) ligand 3
  • Background
  • CCL3, also known as Macrophage inflammatory protein-1α (MIP-1α), is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes (Wolpe et al., 1988). Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha and beta.
  • Synonyms
  • Ccl3; chemokine (C-C motif) ligand 3; Mip1a; Scya3; G0S19-1; AI323804; MIP1-(a); LD78alpha; MIP-1alpha; MIP1-alpha; C-C motif chemokine 3; TY-5; L2G25B; MIP1 (a); SIS-alpha; MIP-1 alpha; MIP-1-alpha; OTTMUSP00000000942; small inducible cytokine A3; small-inducible cytokine A3; heparin-binding chemotaxis protein; macrophage inflammatory protein-1alpha; macrophage inflammatory protein 1-alpha
Cat.#:CCL3-0636HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL3 Protein
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Cat.#:CCL3-0637HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCL3 Protein, GST-Tagged
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Cat.#:Ccl3-2977MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ccl3 Protein
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Cat.#:CCL3-169HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-C motif) Ligand 3, His-tagged
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Cat.#:CCL3-363HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Chemokine (C-C motif) Ligand 3
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Cat.#:CCL3-109HTag:N/A
Source (Host):Species:Human
Product nameHuman CCL3
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Cat.#:CCL3-15HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human CCL3
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Cat.#:CCL3-246HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human CCL3, His-tagged
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Cat.#:CCL3-276HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human CCL3, StrepII-tagged
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Cat.#:CCL3-291HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human CCL3 protein
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Cat.#:CCL3-29859THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL3, His-tagged
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Cat.#:CCL3-475HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human CCL3 protein, His-tagged
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Cat.#:CCL3-705HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL3 protein, His & GST-tagged
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Cat.#:Ccl3-14MTag:N/A
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Ccl3
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Cat.#:Ccl3-292MTag:N/A
Source (Host):E.coliSpecies:Mouse
Product nameRecombinant Mouse Ccl3 protein
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Cat.#:CCL3-2975MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CCL3 Protein
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Cat.#:Ccl3-706MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ccl3 protein, His & GST-tagged
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Cat.#:Ccl3-8705MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ccl3, None tagged
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Cat.#:CCL3-1213RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CCL3 Protein
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Cat.#:Ccl3-544RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ccl3
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Cat.#:Ccl3-56RTag:N/A
Source (Host):E.coliSpecies:Rat
Product nameRecombinant Rat Ccl3 protein
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Cat.#:Ccl3-707RTag:His|GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ccl3 protein, His & GST-tagged
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Cat.#:CCL3-691RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CCL3 Protein, His-tagged
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Cat.#:CCL3-704DTag:His|GST
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog CCL3 protein, His & GST-tagged
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Cat.#:Ccl3-394CTag:N/A
Source (Host):E. coliSpecies:Cotton Rat
Product nameRecombinant Cotton Rat Ccl3
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Cat.#:CCL3-156HTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human Chemokine (C-C Motif) Ligand 3
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Cat.#:CCL3-79HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Chemokine (C-C motif) Ligand 3
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Cat.#:Ccl3-7197MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chemokine (C-C motif) Ligand 3, His-tagged
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Cat.#:CCL3-140ETag:N/A
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine Chemokine (C-C motif) Ligand 3
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Cat.#:CCL3-7723HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CCL3 293 Cell Lysate
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Cat.#:CCL3-119HTag:N/A
Source (Host):Species:Human
Product nameHuman Macrophage Inflammatory Protein-1 alpha (rDNA derived) Reference standard
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Involved Pathway

CCL3 involved in several pathways and played different roles in them. We selected most pathways CCL3 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CCL7; CCR9A; CXCL14; CSF1R; TNFSF8; FASLG; CSF3; INHBE; CXCL11; IFNL3
Chemokine signaling pathway
MAPK3; ADRBK2; GNB4; CCL3L3; CCL11; NFKB1; PPBP; CXCL16; CXCR3; RAC2
Toll-like receptor signaling pathway
RAC1A; TRAF6; MAPK14A; IKBKG; TLR1LA; CXCL9; IFNB; TICAM2; MAPK12; TLR2-2
Salmonella infection
FLNB; MAPK8B; KLC1A; CCL3; CCL3L3; CD14; ACTB1; RHOGB; KLC1; KLC1B
Chagas disease (American trypanosomiasis)
GNA11; PIK3CA; C1QC; FOS; PLCB1; FAS; IFNGR1; NOS2; MYD88; TLR6
Rheumatoid arthritis
ATP6V1A; ATP6V0E1; CCL2; IL6; HLA-DOB; ATP6V1H; FLT1; GM-CSF; HLA-DRB1; ATP6V1D

Protein Function

CCL3 has several biochemical functions, for example, CCR1 chemokine receptor binding, CCR5 chemokine receptor binding, calcium-dependent protein kinase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL3 itself. We selected most functions CCL3 had, and list some proteins which have the same functions with CCL3. You can find most of the proteins on our site.
Function
Related Protein
Function CCR1 chemokine receptor binding
Related Protein CCL3; CCL5; CREB3; CCL4; CCL7; CCL23
Function CCR5 chemokine receptor binding
Related Protein CNIH4; JAK1; CCL3; CCL4; CCL5; STAT3
Function calcium-dependent protein kinase C activity
Related Protein CCL3; PRKCG; ALPK2; PRKCA
Function chemoattractant activity
Related Protein SAA3; CCL5; SCG2; VHL; CCL3; HGF; VEGFA; FGF7; BMP4; NTF3
Function chemokine activity
Related Protein CCL4; CXCL12B; CCL14; CCL16; CCL25B; Ccl9; CXCL12A; CCL22; CXCL3; IL8L2
Function identical protein binding
Related Protein BNIP3; ROBO1; PYDC3; NQO1; HOOK1; ATXN3; GCC2; MICALL1; TP73; APAF1
Function kinase activity
Related Protein EK1; PRKAR2AA; DGKAA; ROCK2A; TRIOA; PRKAB1B; CSNK1G2B; CKBB; SRPK1A; PRKACBB
Function phospholipase activator activity
Related Protein ARHGAP6; CCL3; APOC2; PDPK1; CCL8; GM2A; CCL5
Function protein binding
Related Protein PHF10; MT1G; FRAS1; CD4; TCOF1; NARG1; GLTP; KCNJ15; USP22; OTX2
Function protein kinase activity
Related Protein STK25; EK1; PKN2; SLKA; NPRL2; CASKA; cka1; PRKDC; MYO3A; FGFR1A

Interacting Protein

CCL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL3.
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CCL3 Related Articles

Suviolahti, E; Ge, SL; et al. Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection. TRANSPLANT IMMUNOLOGY 32:9-17(2015).
Gouwy, M; De Buck, M; et al. Serum amyloid A chemoattracts immature dendritic cells and indirectly provokes monocyte chemotaxis by induction of cooperating CC and CXC chemokines. EUROPEAN JOURNAL OF IMMUNOLOGY 45:101-112(2015).

CCL3 Related Gene Family

Chemokines Cytokines