ccl4
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  • Official Full Name
  • chemokine (C-C motif) ligand 4
  • Background
  • CCL4, also known as Macrophage inflammatory protein-1β (MIP-1β) is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Perforin-low memory CD8+ T cells that normally synthesize MIP-1-beta.
  • Synonyms
  • Ccl4; chemokine (C-C motif) ligand 4; MIP-1b; MIP 1 beta; Secreted protein G 26; ACT 2; ACT-2; ACT2; AT744.1; CC chemokine ligand 4; CCL4; CCL4_HUMAN; ccl4l 1; CCL4L1; Chemokine CC Motif Ligand 4; G 26 T lymphocyte secreted protein; G-26 T-lymphocyte-secreted protein; HC21; LAG 1; LAG-1; LAG1; Lymphocyte activation gene 1; Lymphocyte activation gene 1 protein; Macrophage inflammatory protein 1 beta; Macrophage inflammatory protein 1-beta; MGC104418; MGC126025; MGC126026; MIP-1-beta; MIP-1-beta(1-69); MIP-1-beta(3-69); MIP1 beta; MIP1B; MIP1B1; PAT 744; Protein H400; SCYA2; SCYA4; Secreted protein G26; SIS gamma; SIS-gamma; Small inducible cytokine A4; Small-inducible cytokine A4; T cell activation protein 2; T-cell activation protein 2; MIP-1β; Macrophage inflammatory protein-1β
Cat.#:CCL4-934RTag:His
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat CCL4 Protein (Ala24-Asn92), His-tagged
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Cat.#:CCL4-0640HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCL4 Protein, GST-Tagged
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Cat.#:CCL4-2936HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL4 Protein
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Cat.#:CCL4-4390CTag:
Source (Host):YeastSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus Monkey CCL4 Protein
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Cat.#:CCL4-4396ATag:
Source (Host):YeastSpecies:Atlantic Salmon
Product nameRecombinant Atlantic Salmon CCL4 Protein
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Cat.#:CCL4-294HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-C Motif) Ligand 4
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Cat.#:CCL4-421CTag:N/A
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine Chemokine (C-C motif) Ligand 4
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Cat.#:CCL4-10850HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL4, GST-tagged
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Cat.#:CCL4-119HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-C Motif) Ligand 4, MIgG2a Fc-tagged
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Cat.#:CCL4-134HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CCL4, Fc-tagged
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Cat.#:CCL4-16HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human CCL4
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Cat.#:CCL4-183HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-C Motif) Ligand 4, HIgG1 Fc-tagged, mutant
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Cat.#:CCL4-185HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-C Motif) Ligand 4, HIgG1 Fc-tagged
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Cat.#:CCL4-247HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human CCL4, His-tagged
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Cat.#:CCL4-290HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human CCL4, StrepII-tagged
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Cat.#:CCL4-710HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL4 protein, His & GST-tagged
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Cat.#:CCL4-77HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human CCL4
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Cat.#:Ccl4-615MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ccl4
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Cat.#:Ccl4-711MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ccl4 protein, His-tagged
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Cat.#:CCL4-75MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse CCL4
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Cat.#:CCL4-1214RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CCL4 Protein
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Cat.#:Ccl4-634RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ccl4
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Cat.#:Ccl4-712RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ccl4 protein, His-tagged
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Cat.#:CCL4-74RTag:
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat CCL4
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Cat.#:CCL4-631CTag:
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine CCL4
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Cat.#:CCL4-709DTag:His/GST
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog CCL4 protein, His & GST-tagged
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Cat.#:CCL4-76CTag:
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine CCL4
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Cat.#:CCL4-2235CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CCL4
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Cat.#:CCL4-713RTag:His/GST
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit CCL4 protein, His & GST-tagged
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Cat.#:Ccl4-386CTag:
Source (Host):E. coliSpecies:Cotton Rat
Product nameRecombinant Cotton Rat Ccl4
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Cat.#:CCL4-708CTag:His/GST
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle CCL4 protein, His & GST-tagged
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Cat.#:Ccl4-105MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Murine Chemokine (C-C Motif) Ligand 4
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Cat.#:CCL4-159HTag:N/A
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human Chemokine (C-C motif) Ligand 4
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Cat.#:Ccl4-106RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Chemokine (C-C Motif) Ligand 4
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Cat.#:CCL4-137CTag:N/A
Source (Host):YeastSpecies:Chicken
Product nameRecombinant Chicken Chemokine (C-C motif) Ligand 4
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Cat.#:CCL4-146STag:N/A
Source (Host):YeastSpecies:Pig
Product nameRecombinant Swine Chemokine (C-C motif) Ligand 4
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Cat.#:CCL4-7721HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CCL4 293 Cell Lysate
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Involved Pathway

Ccl4 involved in several pathways and played different roles in them. We selected most pathways Ccl4 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ccl4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CCR8L; CD70; FLT4; ACVR1B; AMHR2; Il23a; CCL21B; TP-1; TNFSF4; IL12B
Chemokine signaling pathway
GNGT1; RAP1B; Cxcl15; CXCL11; PIK3CD; CCL6; GNG12; DOCK2; PF4V1; CCL3
NF-kappa B signaling pathway
IRAK1; TICAM2; LTBR; LCK; LTA; TAB2; BCL2L1; ERC1; TRAF3; LAT
Toll-like receptor signaling pathway
CCL3L3; IFNPHI1; TOLLIP; TLR4BA; IFNB1; IFNA17; TLR8; CXCL8B.3; IRF3; AKT2
Cytosolic DNA-sensing pathway
IFNA4; ZBP1; POLR3F; TBK1; TREX1; POLR2F; POLR2EB; NFKBIA; POLR3GL; POLR3D
Salmonella infection
IL8L2; MAPK12; TLR4; IFNG; CXCL2; RAB7; ARPC4L; MAPK13; TJP1; ARPC5LB

Protein Function

Ccl4 has several biochemical functions, for example, CCR1 chemokine receptor binding, CCR5 chemokine receptor binding, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ccl4 itself. We selected most functions Ccl4 had, and list some proteins which have the same functions with Ccl4. You can find most of the proteins on our site.
Function
Related Protein
Function CCR1 chemokine receptor binding
Related Protein CCL3; CCL7; CCL4; CCL5; CCL23; CREB3
Function CCR5 chemokine receptor binding
Related Protein STAT3; CCL5; CNIH4; JAK1; CCL4; CCL3
Function chemokine activity
Related Protein CXCL10; CCL34B.4; CXCL32B.1; CCL23; Ccl9; CCL34B.9; CXCL11.8; CXCL11; CXCL9; CCL19A.2
Function cytokine activity
Related Protein IFNG1-1; BMP7A; BMP8A; IFNA12; Fasl; FAM3D; MIF; WNT1; CD40LG; IL17B
Function identical protein binding
Related Protein KCNH2; CLDN11; L1CAM; SETX; DYNLT1; STAC3; BNIPL; C14orf166; P2RX2; TRADD
Function protein binding
Related Protein BCL6; TFAP2A; SNX19; GDPD5; AGPS; DAB2; TBC1D17; ACHE; BLNK; PLK2

Interacting Protein

Ccl4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ccl4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ccl4.
SLC30A2; IDE; glgX; rnb

Ccl4 Related Articles

Pauta, M; Ribera, J; et al. Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition. LIVER INTERNATIONAL 35:1383-1392(2015).
He, JB; Wang, H; et al. Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy. JOURNAL OF OPHTHALMOLOGY :-(2015).

Ccl4 Related Gene Family

Chemokines Cytokines