CCL4

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CCL4

Official Full Name chemokine (C-C motif) ligand 4
Background CCL4, also known as Macrophage inflammatory protein-1β (MIP-1β) is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Perforin-low memory CD8+ T cells that normally synthesize MIP-1-beta.
Synonyms Ccl4; chemokine (C-C motif) ligand 4; MIP-1b; MIP 1 beta; Secreted protein G 26; ACT 2; ACT-2; ACT2; AT744.1; CC chemokine ligand 4; CCL4; CCL4_HUMAN; ccl4l 1; CCL4L1; Chemokine CC Motif Ligand 4; G 26 T lymphocyte secreted protein; G-26 T-lymphocyte-secreted protein; HC21; LAG 1; LAG-1; LAG1; Lymphocyte activation gene 1; Lymphocyte activation gene 1 protein; Macrophage inflammatory protein 1 beta; Macrophage inflammatory protein 1-beta; MGC104418; MGC126025; MGC126026; MIP-1-beta; MIP-1-beta(1-69); MIP-1-beta(3-69); MIP1 beta; MIP1B; MIP1B1; PAT 744; Protein H400; SCYA2; SCYA4; Secreted protein G26; SIS gamma; SIS-gamma; Small inducible cytokine A4; Small-inducible cytokine A4; T cell activation protein 2; T-cell activation protein 2; MIP-1β; Macrophage inflammatory protein-1β
    • Species :
    • Atlantic Salmon
    • Canine
    • Cattle
    • Chicken
    • Cotton Rat
    • Cynomolgus Monkey
    • Dog
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • S.frugiperda
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • GST
    • His
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Rat CCL4-934R Recombinant Rat CCL4 Protein (Ala24-Asn92), His-tagged Yeast His
    Human CCL4-0640H Recombinant Human CCL4 Protein, GST-Tagged Wheat Germ GST
    Human CCL4-10850H Recombinant Human CCL4, GST-tagged E.coli GST
    Human CCL4-119H Recombinant Human Chemokine (C-C Motif) Ligand 4, MIgG2a Fc-tagged CHO Fc
    Human CCL4-134H Recombinant Human CCL4, Fc-tagged CHO Fc
    Human CCL4-159H Recombinant Human Chemokine (C-C motif) Ligand 4 S.frugiperda N/A
    Human CCL4-16H Recombinant Human CCL4 yeast N/A
    Human CCL4-183H Recombinant Human Chemokine (C-C Motif) Ligand 4, HIgG1 Fc-tagged, mutant CHO Fc
    Human CCL4-185H Recombinant Human Chemokine (C-C Motif) Ligand 4, HIgG1 Fc-tagged CHO Fc
    Human CCL4-247H Recombinant Human CCL4, His-tagged Yeast His
    Human CCL4-290H Recombinant Human CCL4, StrepII-tagged Human Cell Strep II
    Human CCL4-2936H Recombinant Human CCL4 Protein E.coli N/A
    Human CCL4-294H Recombinant Human CCL4 protein E.coli N/A
    Human CCL4-710H Recombinant Human CCL4 protein, His & GST-tagged E.coli His/GST
    Human CCL4-7721HCL Recombinant Human CCL4 293 Cell Lysate HEK293 N/A
    Human CCL4-77H Recombinant Human CCL4 Yeast N/A
    Mouse Ccl4-105M Recombinant Murine Chemokine (C-C Motif) Ligand 4 E.coli N/A
    Mouse Ccl4-615M Recombinant Mouse Ccl4 protein E.coli N/A
    Mouse Ccl4-711M Recombinant Mouse Ccl4 protein, His-tagged E.coli His
    Mouse CCL4-75M Recombinant Mouse CCL4 Yeast N/A
    Rat Ccl4-106R Recombinant Rat Chemokine (C-C Motif) Ligand 4 E.coli N/A
    Rat CCL4-1214R Recombinant Rat CCL4 Protein Mammalian Cell His
    Rat Ccl4-634R Recombinant Rat Ccl4 protein E.coli N/A
    Rat Ccl4-712R Recombinant Rat Ccl4 protein, His-tagged E.coli His
    Rat CCL4-74R Recombinant Rat CCL4 Yeast N/A
    Cynomolgus Monkey CCL4-4390C Recombinant Cynomolgus Monkey CCL4 Protein Yeast N/A
    Canine CCL4-421C Recombinant Canine Chemokine (C-C motif) Ligand 4 E.coli N/A
    Canine CCL4-631C Recombinant Canine CCL4 E.coli N/A
    Dog CCL4-709D Recombinant Dog CCL4 protein, His & GST-tagged E.coli His/GST
    Canine CCL4-76C Recombinant Canine CCL4 Yeast N/A
    Chicken CCL4-137C Recombinant Chicken Chemokine (C-C motif) Ligand 4 Yeast N/A
    Chicken CCL4-2235C Recombinant Chicken CCL4 Mammalian Cell His
    Rabbit CCL4-713R Recombinant Rabbit CCL4 protein, His & GST-tagged E.coli His/GST
    Pig CCL4-146S Recombinant Swine Chemokine (C-C motif) Ligand 4 Yeast N/A
    Cotton Rat Ccl4-386C Recombinant Cotton Rat Ccl4 E.coli N/A
    Atlantic Salmon CCL4-4396A Recombinant Atlantic Salmon CCL4 Protein Yeast N/A
    Cattle CCL4-708C Recombinant Cattle CCL4 protein, His & GST-tagged E.coli His/GST

    CCL4 involved in several pathways and played different roles in them. We selected most pathways CCL4 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction PDGFRB; TNFSF10; IL7; RNF207B; IFNA6; FASLG; PDGFAB; BMPR1AA; CCL25; TGFBR1A
    Chemokine signaling pathway PIK3CG; CCL7; PIK3CB; RAC1; GM13306; PIK3R1; STAT1; HRAS; SHC1; GNG3
    NF-kappa B signaling pathway RIPK1; MAP3K7IP3; CD40; LBP; BCL2A1; LAT; TICAM2; GADD45B; CCL19; BCL10
    Toll-like receptor signaling pathway PIK3R5; TLR4; IFNPHI1; TNF; PIK3R3; STAT1; PIK3R3B; IRF7; TAB2; TLR7
    Cytosolic DNA-sensing pathway POLR3C; IL33; NFKB1; POLR2L; IL18; IFNA16; ADAR; POLR3B; POLR2E; Ifna11
    Salmonella infection IFNGR1; LBP; MAPK14B; PFN2; IL6; ARPC5LB; CCL4L2; MAPK10; RHOGB; CXCL2

    CCL4 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL4 itself. We selected most functions CCL4 had, and list some proteins which have the same functions with CCL4. You can find most of the proteins on our site.

    Function Related Protein
    CCR1 chemokine receptor binding CCL3; CCL23; CCL5; CREB3; CCL7; CCL4
    CCR5 chemokine receptor binding CNIH4; CCL4; CCL5; STAT3; CCL3; JAK1
    chemokine activity CCL3L1; Ccl12; CCL19A.2; CCL5; CCL14; CXCL12B; CCL19B; AMCF-II; CCL19A.1; Ccl9
    cytokine activity CMTM6; IFNL3; IL17C; TIMP1; INHBA; GDF7; HMGB1A; CMTM8; VEGFA; FAM3C
    identical protein binding SYT9; UBE4A; GSTM3; GOT2A; CBLL1; CLDND; SMURF2; SHMT2; HNRNPC; TYROBP
    protein binding PYCRL; TRIM71; ATP6V0C; UBA1; WAPAL; FGFRL1B; FOXO3B; MAPRE1; SERPINB5; MEPE

    CCL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL4.

    SLC30A2; IDE; glgX; rnb

    Pauta, M; Ribera, J; et al. Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition. LIVER INTERNATIONAL 35:1383-1392(2015).
    He, JB; Wang, H; et al. Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy. JOURNAL OF OPHTHALMOLOGY :-(2015).

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