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TNFSF8

  • Official Full Name

    tumor necrosis factor (ligand) superfamily, member 8

  • Overview

    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    TNFSF8; tumor necrosis factor (ligand) superfamily, member 8; CD30LG; tumor necrosis factor ligand superfamily member 8; CD153; CD30-L; CD30 ligand; CD153 antigen; CD30 antigen ligand; CD30L; MGC138144;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus Macaque
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Myc
  • DDK
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • Mouse|IgG2a|Fc
  • Myc|DDK
  • N/A
  • N
  • hFc
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFSF8-569H Active Recombinant Human TNFSF8, His-tagged, Biotinylated Human Cell His
Human TNFSF8-890H Active Recombinant Human TNFSF8 Protein, His-tagged CHO His
Human TNFSF8-570H Active Recombinant Human TNFSF8, Fc-tagged, Biotinylated Human Cell Fc
Human TNFSF8-322H Active Recombinant Human TNFSF8 Protein (Gln63-Asp234), C-His tagged, Animal-free, Carrier-free E.coli C-His Gln63-Asp234
Human TNFSF8-2076H Recombinant Human TNFSF8, FLAG-tagged HEK293 Flag
Human TNFSF8-63H Recombinant Human TNFSF8 protein, His-tagged Insect Cell His
Human TNFSF8-156H Recombinant Human TNFSF8, His-tagged E.coli His 63- 234aa
Human TNFSF8-1595H Recombinant Human TNFSF8 Mammalian cells N/A
Human TNFSF8-3322H Recombinant Human TNFSF8, GST-tagged E.coli GST 61-234aa
Human TNFSF8-60H Active Recombinant Human TNFSF8, Fc tagged HEK293 Fc Gln 63-Asp 234
Human TNFSF8-248H Recombinant Human TNFSF8, StrepII-tagged Human Cell Strep II 1-234, 234 a.a.
Human TNFSF8-3051HCL Recombinant Human TNFSF8 cell lysate Human Cell N/A
Human TNFSF8-2258H Recombinant Human TNFSF8 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TNFSF8-326H Recombinant Human TNFSF8 Protein (Gln63-Asp234), Gly & Pro HEK293 N/A Gln63-Asp234
Human TNFSF8-829H Recombinant Human TNFSF8 protein, His-tagged, low endotoxin HEK293 His Gln63-Asp234
Human TNFSF8-21H Recombinant Human TNFSF8 Protein (K166A+I168A+K169A), His-tagged HEK293 His
Human TNFSF8-333H Recombinant Human TNFSF8 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc 172
Human TNFSF8-18H Recombinant Human TNFSF8 Protein (Y126A), His-tagged HEK293 His
Human TNFSF8-015H Recombinant Human TNFSF8 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human TNFSF8-22H Recombinant Human TNFSF8 Protein (S83A), His-tagged HEK293 His
Human TNFSF8-189H Recombinant Human TNFSF8 Protein, C-His-tagged E.coli C-His
Human TNFSF8-20H Recombinant Human TNFSF8 Protein (D234A+N165A), His-tagged HEK293 His
Human TNFSF8-3577H Recombinant Human TNFSF8 protein, His-tagged E.coli His 61-234 aa
Human TNFSF8-23H Recombinant Human TNFSF8 Protein (K78A), His-tagged HEK293 His
Human TNFSF8-13H Recombinant Human TNFSF8 Protein (D234A), His-tagged HEK293 His
Human TNFSF8-5340H Recombinant Human TNFSF8 Protein (Gln63-Asp234), N-Fc tagged Mammalian cells N-Fc Gln63-Asp234
Human TNFSF8-12H Recombinant Human TNFSF8 Protein (R92S), His-tagged HEK293 His
Human TNFSF8-24H Recombinant Human TNFSF8 Protein (R125A), His-tagged HEK293 His
Human TNFSF8-14H Recombinant Human TNFSF8 Protein (K169A), His-tagged HEK293 His
Human TNFSF8-4502H Recombinant Human TNFSF8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TNFSF8-17H Recombinant Human TNFSF8 Protein (K166A), His-tagged HEK293 His
Human TNFSF8-182H Recombinant Human TNFSF8 Protein, His-tagged Human Cells His
Human TNFSF8-15H Recombinant Human TNFSF8 Protein (N165A), His-tagged HEK293 His
Human TNFSF8-19H Recombinant Human TNFSF8 Protein (K110A), His-tagged HEK293 His
Human TNFSF8-16H Recombinant Human TNFSF8 Protein (I168A), His-tagged HEK293 His
Human TNFSF8-4502H-B Recombinant Human TNFSF8 Protein Pre-coupled Magnetic Beads HEK293
Human TNFSF8-0907H Recombinant Human TNFSF8 Protein (Leu60-Ile227), N-His tagged E.coli N-His Leu60-Ile227
Mouse Tnfsf8-780M Recombinant Mouse Tnfsf8 protein, His-tagged E.coli His Gln68~Ser231 (Accession # P32972)
Mouse Tnfsf8-1714M Recombinant Mouse Tnfsf8 Mammalian cells N/A
Mouse TNFSF8-17180M Recombinant Mouse TNFSF8 Protein Mammalian Cell His
Mouse Tnfsf8-10626M Recombinant Mouse Tnfsf8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TNFSF8-9487M Recombinant Mouse TNFSF8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TNFSF8-9487M-B Recombinant Mouse TNFSF8 Protein Pre-coupled Magnetic Beads HEK293
Mouse Tnfsf8-10626M-B Recombinant Mouse Tnfsf8 Protein Pre-coupled Magnetic Beads HEK293
Mouse Tnfsf8-6558M Recombinant Mouse Tnfsf8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Tnfsf8-781R Recombinant Rat Tnfsf8 protein, His & GST-tagged E.coli His/GST Asp69~Tyr233 (Accession # M0R3V3)
Rat Tnfsf8-8723R Active Recombinant Rat Tnfsf8 protein(Gln66-Asp237), hFc-tagged HEK293 N-hFc Gln66-Asp237
Rat TNFSF8-381R Recombinant Rat Tnfsf8, Gly & Pro tagged Human Cell Fc
Rat TNFSF8-1053RCL Recombinant Rat TNFSF8 cell lysate Human Cell N/A
Cynomolgus TNFSF8-68C Active Recombinant Cynomolgus TNFSF8, His tagged HEK293 His Gln63-Asp234
Cynomolgus TNFSF8-8821C Active Recombinant Cynomolgus TNFSF8, Fc tagged HEK293 Fc Gln63-Asp234
Cynomolgus Monkey TNFSF8-1190CCL Recombinant Cynomolgus TNFSF8 cell lysate Human Cell N/A
Homo sapiens (Human) RFL13162HF Recombinant Full Length Human Tumor Necrosis Factor Ligand Superfamily Member 8(Tnfsf8) Protein, His-Tagged E.coli expression system His Full Length (1-234)
Mus musculus (Mouse) RFL25423MF Recombinant Full Length Mouse Tumor Necrosis Factor Ligand Superfamily Member 8(Tnfsf8) Protein, His-Tagged E.coli expression system His Full Length (1-239)
Rhesus Macaque TNFSF8-4876R Recombinant Rhesus monkey TNFSF8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TNFSF8-4690R Recombinant Rhesus Macaque TNFSF8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TNFSF8-4690R-B Recombinant Rhesus Macaque TNFSF8 Protein Pre-coupled Magnetic Beads HEK293
Chicken TNFSF8-5979C Recombinant Chicken TNFSF8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TNFSF8 Related Gene Family
  • TNFSF8 Related Research Area
  • TNFSF8 Related Signal Pathway

TNFSF8 involved in several pathways and played different roles in them. We selected most pathways TNFSF8 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIFNW1;TNFRSF10C;CXCL12B;IL12B;VEGFB;TNFRSF18;Ifna11;CXCR7;CCL25

TNFSF8 has several biochemical functions, for example, cytokine activity, receptor binding, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF8 itself. We selected most functions TNFSF8 had, and list some proteins which have the same functions with TNFSF8. You can find most of the proteins on our site.

Function Related Protein
cytokine activityWNT7A;IFNG1-2;CMTM5;TNFSF15;TIMP1;KITLG;IL10;BMP7;IFNPHI4
receptor bindingFKBP1B;TIGIT;UTS2;FGF11;FIS1;HSD17B4;NPFF;PTK2AA;CD72
tumor necrosis factor receptor bindingTRIM37;TNFSF14;TRAF3;FASLG;TNFSF8;TNFSF10L4;ERAP1;FADD;TNFSF4

TNFSF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFSF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFSF8.

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