cd40lg
Share
  • Official Full Name
  • CD40 ligand
  • Background
  • The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.
  • Synonyms
  • CD40LG; CD40 ligand; IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L; CD40-L; CD40 antigen ligand; T-cell antigen Gp39; T-B cell-activating molecule; TNF-related activation protein; tumor necrosis factor (ligand) superfamily member 5; tu
Cat.#:CD40LG-280HTag:Avi|Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD40LG Protein, Fc-Avi-tagged, Biotinylated
+Inquiry
Cat.#:CD40LG-392RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit CD40LG Protein (113-261 aa), His-tagged
+Inquiry
Cat.#:CD40LG-0815HTag:N/A
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD40LG Protein
+Inquiry
Cat.#:CD40LG-0816HTag:His|Flag|StrepII
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CD40LG Protein, His-Flag-StrepII-Tagged
+Inquiry
Cat.#:CD40LG-0818HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD40LG Protein, GST-Tagged
+Inquiry
Cat.#:Cd40lg-4371MTag:N/A
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Cd40lg Protein
+Inquiry
Cat.#:CD40LG-22HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Soluble CD40 Ligand
+Inquiry
Cat.#:Cd40lg-98MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse CD40 Ligand
+Inquiry
Cat.#:CD40LG-324HTag:Mouse|IgG2a|Fc
Source (Host):HEK293Species:Human/Rhesus macaque
Product nameRecombinant Human/Rhesus macaque CD40LG protein, Mouse IgG2a Fc-tagged, low endotoxin
+Inquiry
Cat.#:CD40LG-325MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD40LG protein, His-tagged
+Inquiry
Cat.#:CD40LG-117HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD40LG Protein, His-tagged
+Inquiry
Cat.#:CD40LG-193HTag:Flag
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD40LG, FLAG-tagged
+Inquiry
Cat.#:CD40LG-23HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD40LG
+Inquiry
Cat.#:CD40LG-26080THTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human CD40LG protein
+Inquiry
Cat.#:CD40LG-27811THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD40LG, His-tagged
+Inquiry
Cat.#:CD40LG-279HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD40LG, Fc tagged
+Inquiry
Cat.#:CD40LG-33HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD40LG, HIgG1 Fc-tagged
+Inquiry
Cat.#:CD40LG-34HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD40LG, MIgG2a Fc-tagged
+Inquiry
Cat.#:CD40LG-4737HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD40 Ligand
+Inquiry
Cat.#:CD40LG-783HTag:His|S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD40LG protein, His & S-tagged
+Inquiry
Cat.#:CD40LG-784HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD40LG protein, His-tagged
+Inquiry
Cat.#:CD40LG-785HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD40LG protein, His & GST-tagged
+Inquiry
Cat.#:Cd40lg-404MTag:Flag
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Cd40lg, FLAG-tagged
+Inquiry
Cat.#:Cd40lg-43MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd40lg, Fc-tagged
+Inquiry
Cat.#:Cd40lg-786MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cd40lg protein, His & GST-tagged
+Inquiry
Cat.#:CD40lg-83MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse CD40lg protein, His-tagged
+Inquiry
Cat.#:CD40LG-1253RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CD40LG Protein
+Inquiry
Cat.#:Cd40lg-405RTag:Flag
Source (Host):CHOSpecies:Rat
Product nameRecombinant Rat Cd40lg, FLAG-tagged
+Inquiry
Cat.#:Cd40lg-545RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd40lg, Fc tagged
+Inquiry
Cat.#:Cd40lg-790RTag:His|GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cd40lg protein, His & GST-tagged
+Inquiry
Cat.#:Cd40lg-8725RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd40lg, Fc-tagged
+Inquiry
Cat.#:CD40LG-69CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD40LG, Fc tagged
+Inquiry
Cat.#:CD40LG-741RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CD40LG Protein, His-tagged
+Inquiry
Cat.#:CD40LG-791RTag:His
Source (Host):E. coliSpecies:Rhesus monkey
Product nameRecombinant Rhesus monkey CD40LG protein, His-tagged
+Inquiry
Cat.#:CD40LG-107CTag:N/A
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine CD40LG
+Inquiry
Cat.#:CD40LG-166CTag:N/A
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine CD40LG
+Inquiry
Cat.#:CD40LG-167CTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine CD40LG, Fc-tagged
+Inquiry
Cat.#:CD40LG-108CTag:N/A
Source (Host):YeastSpecies:Chicken
Product nameRecombinant Chicken CD40LG
+Inquiry
Cat.#:CD40LG-25RTag:His
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit CD40LG Protein, His-tagged
+Inquiry
Cat.#:CD40LG-6298CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CD40LG
+Inquiry
Cat.#:CD40LG-7294ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CD40LG
+Inquiry
Cat.#:CD40LG-102STag:N/A
Source (Host):YeastSpecies:Pig
Product nameRecombinant Swine CD40LG
+Inquiry
Cat.#:CD40LG-782CTag:His|GST
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle CD40LG protein, His & GST-tagged
+Inquiry
Cat.#:CD40LG-787PTag:His|S
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig CD40LG protein, His & S-tagged
+Inquiry
Cat.#:CD40LG-788PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig CD40LG protein, His-tagged
+Inquiry
Cat.#:CD40LG-789PTag:His|GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig CD40LG protein, His & GST-tagged
+Inquiry
Cat.#:CD40LG-019ETag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD40LG (108-261aa)
+Inquiry
Cat.#:CD40LG-1965HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD40LG cell lysate
+Inquiry
Cat.#:CD40LG-1548MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD40LG cell lysate
+Inquiry
Cat.#:CD40LG-1205RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat CD40LG cell lysate
+Inquiry
Cat.#:CD40LG-1080CCLTag:N/A
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD40LG cell lysate
+Inquiry
Cat.#:CD40LG-001CCLTag:N/A
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine CD40LG cell lysate
+Inquiry
Cat.#:CD40LG-156HGTag:N/A
Source (Host):HEK293 cellSpecies:Human
Product nameGMP Recombinant Human CD40LG Protein
+Inquiry
Cat.#:CD40LG-4349HGTag:N/A
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human CD40LG protein
+Inquiry

Involved Pathway

CD40LG involved in several pathways and played different roles in them. We selected most pathways CD40LG participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD40LG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
GHR; IL17RA; IL4; RELT; CX3CR1; CD27; PDGFRB; IL22RA1; ACVR2B; CXCL3
NF-kappa B signaling pathway
CD40; CFLAR; TAB2; BCL2A1A; IL1R1; BCL2; PTGS2; TRADD; CCL4; MAP3K14
Cell adhesion molecules (CAMs)
LRRC4C; HLA-G; HLA-DQA2; PVRL3B; MHC2A; Ntng2; CD274; SDC4; HLA-DPA1; ITGAL
T cell receptor signaling pathway
NFKB1; KRAS; CD247; CD40LG; NCK2; PAK6; CBLB; PPP3CB; ZAP70; CARD11
Intestinal i
CCL27B; IL4; CXCR4; CCL28; PIGR; CD80; CXCL12A; IL6; LTBR; TNFRSF17
ne network for IgA production
CCL25; CD28; BLA; IL4; CXCR4B; IL5; ICOS; TNFRSF13B; MHC2DCB; MAP3K14
Malaria
ITGB2L; IL6; CD36; THBS1; IFNG; GYPA; TNF; HBA1; CSF3; COMP
Toxoplasmosis
HSPA1B; TLR2; GNAI3; H2-AA; HLA-DQA1; H2-AB1; NFKB1; ITGA6; IL10RA; LAMA1
Asthma
CCL11; HLA-DMA; EPX; HLA-DPB1; IL13; H2-AA; FCER1G; IL4; IL5; TNF
Autoi
TSHB; IFNA14; HLA-DRB5; IFNA7; HLA-DRB1; IFNA12; H2-AA; IFNA5; HLA-DMB; Il2
ne thyroid disease
HLA-DMB; H2-AA; IFNA8; IFNA14; CD40LG; HLA-DMA; HLA-DRB4; HLA-DQA2; HLA-DOA; IFNA7
Systemic lupus erythematosus
GM14477; HIST1H2BC; HIST1H2BP; HLA-DRB4; HIST2H2BE; HIST1H2BL; ACTN4; HIST1H4E; HIST2H4A; HIST1H2BH
Allograft rejection
HLA-B; CD40LG; IL10; Il2; PRF1; CD80; IFNG; MICA; HLA-DPA1; HLA-DMB
Primary i
RFXANK; CD3E; CD40; IGLL1; AIRE; DCLRE1C; CD8A; RFXAP; CD3D; RAG1
nodeficiency
AICDA; BTK; AIRE; CD40LG; LCK; CD40; ORAI1; CD19; UNG; RFXANK
Viral myocarditis
CD40LG; HLA-DQB1; HLA-DOB; HLA-DPA1; ICAM1; H2-Q10; HLA-DPB1; Casp3; HLA-DQA2; CD80

Protein Function

CD40LG has several biochemical functions, for example, CD40 receptor binding, cytokine activity, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD40LG itself. We selected most functions CD40LG had, and list some proteins which have the same functions with CD40LG. You can find most of the proteins on our site.
Function
Related Protein
Function CD40 receptor binding
Related Protein TRAF2; CD40LG
Function cytokine activity
Related Protein BMP7A; LTA; KITLG; GDF5; TNFSF14; Il2; NDR2; IL36RN; MSTNA; TGFB1
Function tumor necrosis factor receptor binding
Related Protein TNFB; LTB; TRAF1; TNFSF10; TNFSF10L4; TRIM37; TRADD; FADD; TRAF2; CASP8

CD40LG Related Articles

Britze, A; Palmfeldt, J; et al. 44-plex cytokine profile of cholesteatoma. ACTA OTO-LARYNGOLOGICA 134:41-50(2014).
Strickland, FM; Hewagama, A; et al. Diet Influences Expression of Autoimmune-Associated Genes and Disease Severity by Epigenetic Mechanisms in a Transgenic Mouse Model of Lupus. ARTHRITIS AND RHEUMATISM 65:1872-1881(2013).