cxcl2
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  • Official Full Name
  • chemokine (C-X-C motif) ligand 2
  • Background
  • Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.
  • Synonyms
  • GROb; Gro2; Mip2; Scyb; MIP-2; Scyb2; MIP-2a; Mgsa-b; CINC-2a; Cxcl2; chemokine (C-X-C motif) ligand 2
Cat.#:CXCL2-401HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL2 Protein (Ala35-Asn107)
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Cat.#:CXCL2-2165PTag:His-Flag-StrepII
Source (Host):Human cellsSpecies:Human
Product nameRecombinant CXCL2 Protein, His-Flag-StrepII-tagged
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Cat.#:CXCL2-2167HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CXCL2 Protein, GST-tagged
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Cat.#:Cxcl2-2169MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cxcl2 Protein
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Cat.#:Cxcl2-3390MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cxcl2 Protein
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Cat.#:CXCL2-224HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human chemokine (C-X-C motif) ligand 2, His-tagged
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Cat.#:CXCL2-476HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C Motif) Ligand 2
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Cat.#:CXCL2-17HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human CXCL2
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Cat.#:CXCL2-282HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human CXCL2, StrepII-tagged
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Cat.#:Cxcl2-13MTag:N/A
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Cxcl2
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Cat.#:Cxcl2-200MTag:His/SUMO
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cxcl2, His & SUMO tagged
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Cat.#:Cxcl2-38MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chemokine (C-X-C Motif) Ligand 2
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Cat.#:CXCL2-4105MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CXCL2 Protein
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Cat.#:Cxcl2-428MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Cxcl2 protein, His-tagged
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Cat.#:Cxcl2-1070RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cxcl2 Protein
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Cat.#:CXCL2-1689RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CXCL2 Protein
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Cat.#:Cxcl2-54RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Chemokine (C-X-C Motif) Ligand 2
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Cat.#:Cxcl2-578RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cxcl2 protein, His & GST-tagged
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Cat.#:Cxcl2-626RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cxcl2
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Cat.#:Cxcl2-395CTag:
Source (Host):E. coliSpecies:Cotton Rat
Product nameRecombinant Cotton Rat Cxcl2
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Cat.#:CXCL2-7168HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CXCL2 293 Cell Lysate
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Cat.#:CKERS-CXCL2-019HTag:
Source (Host):Species:Human
Product nameHuman CXCL2 ELISA Kit
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Involved Pathway

Cxcl2 involved in several pathways and played different roles in them. We selected most pathways Cxcl2 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cxcl2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
TNFB; IL1B; IL10; CXCR4B; IL20; CSF2RB; CTF1; CCL19B; CXCL16; IL7
Chemokine signaling pathway
GNB3; CXCL3; BCAR1; ARRB2; KRAS; CCL5; MAPK1; GNG13; MAPK3; CCL4L1
NF-kappa B signaling pathway
PLAU; GM13304; LAT; VCAM1; MYD88; PTGS2; CARD11; ZAP70; TNFRSF1A; MAP3K7IP3
NOD-like receptor signaling pathway
NLRP3; NLRP1; IL1B; CASPA; MAPK9; NFKB1; NFKBIAA; MAPK12A; RIPK2; MAPK13
TNF signaling pathway
TRAF2; MAP3K14; RIPK1; PIK3R2; SOCS3; MLKL; PIK3R1; PIK3CA; PIK3CD; ITCH
Salmonella infection
ARPC5A; IFNGR1; CDC42; NFKB1; RELA; DYNC1LI2; PFN4; FLNA; IL1A; FLNC
Legionellosis
NFKBIA; ITGAM; CXCL1; TLR5; CASP8; NFKB2; APAF1; HBS1L; CASP1; CASP9

Protein Function

Cxcl2 has several biochemical functions, for example, CXCR chemokine receptor binding, chemokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Cxcl2 itself. We selected most functions Cxcl2 had, and list some proteins which have the same functions with Cxcl2. You can find most of the proteins on our site.
Function
Related Protein
Function CXCR chemokine receptor binding
Related Protein CXCL12A; CXCL12B; CXCL1; CXCL6; CXCL2; AMCF-II; CXCL3; PPBP; ITCH; PF4V1
Function chemokine activity
Related Protein CCL38A.4; CXCL11; C5; CCL33.3; CCL27; Cxcl15; CCL1; CXCL5; CCL20; CCL19A.1
Function protein binding
Related Protein RNF41; TMEM115; RBM12B; CALCRL; PPP1R37; ARHGEF1; ZFP57; ERCC2; ETV6; MECOM

Interacting Protein

Cxcl2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cxcl2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cxcl2.
DPP4; EPS8; PIK3R5

Cxcl2 Related Articles

Maeda, A; Bandow, K; et al. Induction of CXCL2 and CCL2 by pressure force requires IL-1 beta-MyD88 axis in osteoblasts. BONE 74:76-82(2015).
McDermott, AJ; Higdon, KE; et al. The role of Gr-1(+) cells and tumour necrosis factor-alpha signalling during Clostridium difficile colitis in mice. IMMUNOLOGY 144:704-716(2015).

Cxcl2 Related Gene Family

Chemokines Cytokines