f3
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  • Official Full Name
  • coagulation factor III (thromboplastin, tissue factor)
  • Background
  • This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
  • Synonyms
  • F3; coagulation factor III (thromboplastin, tissue factor); TF; TFA; CD142; tissue factor;
Cat.#:F3-1023CTag:His
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus F3 Protein (Met1-Glu252), His-tagged
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Cat.#:F3-2046HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human F3 Protein, His-tagged
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Cat.#:F3-368RTag:His
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit F3 Protein, His-tagged
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Cat.#:F3-565HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human F3 Protein (Met1-Ser295), His-tagged
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Cat.#:F3-3619HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human F3 Protein
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Cat.#:F3-3620HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human F3 Protein, GST-tagged
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Cat.#:F3-958HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human F3 Protein, MYC/DDK-tagged
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Cat.#:F3-463HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Coagulation Factor III (Thromboplastin, Tissue Factor)
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Cat.#:F3-18HTag:
Source (Host):Species:Human
Product nameRecombinant Human Tissue Factor, Non-Lipidated
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Cat.#:F3-19HTag:
Source (Host):Species:Human
Product nameRecombinant Human Tissue Factor, Lipidated
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Cat.#:F3-20HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human F3 protein, His-tagged
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Cat.#:F3-22HTag:
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human F3 protein
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Cat.#:F3-28HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Soluble Tissue Factor
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Cat.#:F3-6924HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human F3, Fc tagged
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Cat.#:F3-6925HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human F3, His tagged
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Cat.#:F3-99HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human F3, His-tagged
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Cat.#:F3-2734MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse F3 protein, His-tagged
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Cat.#:F3-32MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse F3 protein, His-tagged
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Cat.#:F3-426MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse F3, His tagged
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Cat.#:F3-459MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Coagulation Factor III
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Cat.#:F3-47MTag:His
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse F3 Protein, His-tagged
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Cat.#:F3-2735RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat F3 protein, His-tagged
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Cat.#:F3-29RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat F3, His-tagged
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Cat.#:F3-8752RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat F3, His tagged
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Cat.#:F3-1029RTag:His
Source (Host):HEK293Species:Rabbit
Product nameRecombinant Rabbit F3 Protein, His-tagged
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Cat.#:F3-2736RTag:His/S
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit F3 protein, His & S-tagged
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Cat.#:F3-455RTag:N/A
Source (Host):T7Species:Rabbit
Product nameRecombinant Rabbit Coagulation Factor III (Thromboplastin, Tissue Factor)
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Cat.#:F3-2733CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle F3 protein, His & T7-tagged
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Cat.#:F3-1691HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human F3 cell lysate
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Cat.#:F3-2503MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse F3 cell lysate
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Cat.#:F3-1256RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat F3 cell lysate
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Cat.#:F3-172HTag:
Source (Host):Species:Human
Product nameRecombinant Human Thromboplastin, Plain Reference standard
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Cat.#:F3-15RTag:
Source (Host):Species:Rabbit
Product nameRabbit Thromboplastin Reference Standard
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Involved Pathway

F3 involved in several pathways and played different roles in them. We selected most pathways F3 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with F3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
SERPINA1A; F7; CFH; PROS1; C5AR1; C1R; CR1L; SERPINA5; F11; Hc

Protein Function

F3 has several biochemical functions, for example, cytokine receptor activity, phospholipid binding, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by F3 itself. We selected most functions F3 had, and list some proteins which have the same functions with F3. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine receptor activity
Related Protein Ifnlr1; IRX1; GHRA; IL12RB1; CRFB12; IL12B; IL4R.1; IL1RL1; LIFRB; IL21R.2
Function phospholipid binding
Related Protein APOA1; APOE; PACSIN1; PRKCI; PLA2G2A; NBEA; SMURF1; BAIAP2L2; APOM; BIN2
Function protease binding
Related Protein TIMP2; BDKRB2; INS; ITGA3; FURIN; ECM1; PANX1; ITGB1; BCL10; SERPINB6
Function protein binding
Related Protein CPSF4; APOB; LXN; FZD3; MRM1; CHCHD1; TACC1; ZKSCAN5; DAG1; IFT88

Interacting Protein

F3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F3 here. Most of them are supplied by our site. Hope this information will be useful for your research of F3.
F7

F3 Related Articles

Bet, A; Maze, EA; et al. The HIV-1 Antisense Protein (ASP) induces CD8 T cell responses during chronic infection. RETROVIROLOGY 12:-(2015).
Sritharan, N; Choudhury, M; et al. Highly immunoreactive antibodies against the rHup-F2 fragment (aa 63-161) of the iron-regulated HupB protein of Mycobacterium tuberculosis and its potential for the serodiagnosis of extrapulmonary and recurrent tuberculosis. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 34:33-40(2015).

F3 Related Gene Family

TGF Cytokines