F3 Protein, coagulation factor III (thromboplastin, tissue factor)

F3

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F3

Official Full Name coagulation factor III (thromboplastin, tissue factor)
Background This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Synonyms F3; coagulation factor III (thromboplastin, tissue factor); TF; TFA; CD142; tissue factor;
    • Species :
    • Cattle
    • Cynomolgus
    • Human
    • Mouse
    • Rabbit
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • NS0
    • Rabbit
    • T7 cell
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • GST
    • His
    • S
    • T7
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cynomolgus F3-1023C Recombinant Cynomolgus F3 Protein (Met1-Glu252), His-tagged HEK293 His
    Human F3-2046H Recombinant Human F3 Protein, His-tagged HEK293 His
    Rabbit F3-368R Recombinant Rabbit F3 Protein, His-tagged Yeast His
    Human F3-565H Recombinant Human F3 Protein (Met1-Ser295), His-tagged Insect Cell His
    Mouse F3-999M Recombinant Mouse F3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human F3-1691HCL Recombinant Human F3 cell lysate Human Cell N/A
    Human F3-172H Recombinant Human Thromboplastin, Plain Reference standard N/A
    Human F3-18H Recombinant Human Tissue Factor, Non-Lipidated N/A
    Human F3-19H Recombinant Human Tissue Factor, Lipidated N/A
    Human F3-20H Recombinant Human F3 protein, His-tagged NS0 His
    Human F3-22H Recombinant Human F3 protein Insect Cell N/A
    Human F3-28H Recombinant Human Soluble Tissue Factor E.coli N/A
    Human F3-3619H Recombinant Human F3 Protein Wheat Germ N/A
    Human F3-3620H Recombinant Human F3 Protein, GST-tagged Wheat Germ GST
    Human F3-463H Recombinant Human Coagulation Factor III (Thromboplastin, Tissue Factor) Insect Cell N/A
    Human F3-6924H Recombinant Human F3, Fc tagged Human Cell Fc
    Human F3-6925H Recombinant Human F3, His tagged Human Cell His
    Human F3-958H Recombinant Human F3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human F3-99H Recombinant Human F3, His-tagged E.coli His
    Mouse CAB11537RM Rabbit Anti-Mouse Coagulation Factor III / Tissue Factor / CD142 Monoclonal Antibody Rabbit N/A
    Mouse F3-2503MCL Recombinant Mouse F3 cell lysate Human Cell N/A
    Mouse F3-2734M Recombinant Mouse F3 protein, His-tagged E.coli His
    Mouse F3-32M Recombinant Mouse F3 protein, His-tagged NS0 His
    Mouse F3-426M Recombinant Mouse F3, His tagged Human Cell His
    Mouse F3-459M Recombinant Mouse Coagulation Factor III E.coli N/A
    Mouse F3-47M Recombinant Mouse F3 Protein, His-tagged Insect Cell His
    Rat F3-1256RCL Recombinant Rat F3 cell lysate Human Cell N/A
    Rat F3-2735R Recombinant Rat F3 protein, His-tagged E.coli His
    Rat F3-29R Recombinant Rat F3, His-tagged Human Cell His
    Rat F3-8752R Recombinant Rat F3, His tagged Human Cell His
    Rabbit F3-1029R Recombinant Rabbit F3 Protein, His-tagged HEK293 His
    Rabbit F3-15R Rabbit Thromboplastin Reference Standard N/A
    Rabbit F3-2736R Recombinant Rabbit F3 protein, His & S-tagged E.coli His/S
    Rabbit F3-455R Recombinant Rabbit Coagulation Factor III (Thromboplastin, Tissue Factor) T7 cell N/A
    Cattle F3-2733C Recombinant Cattle F3 protein, His & T7-tagged E.coli His/T7

    F3 involved in several pathways and played different roles in them. We selected most pathways F3 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with F3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascades F2R; C3AR1; F11; CD59A; PLAU; FGB; CD46; BDKRB1; C4BP; MASP1

    F3 has several biochemical functions, for example, cytokine receptor activity, phospholipid binding, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by F3 itself. We selected most functions F3 had, and list some proteins which have the same functions with F3. You can find most of the proteins on our site.

    Function Related Protein
    cytokine receptor activity Il6ra; F3; PRLRA; LIFRB; CRFB15; Ifnlr1; IL20RB; Il4ra; IL12B; FLT3
    phospholipid binding HIP1RB; NBEA; CPS1; OSBPL1A; SYTL4; SHC1; ABCG1; APOM; PACSIN1A; F10
    protease binding BRCA2; DVL3; RFFL; ELANE; CFLAR; OS9; KIT; SERPINA1D; SRI; SERPINB4
    protein binding AKAP17A; NOL4; NECAB3; PIH1D3; FBXO5; LHX9; RHNO1; PPP1R9A; TGFA; PIFO

    F3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F3 here. Most of them are supplied by our site. Hope this information will be useful for your research of F3.

    F7

    Bet, A; Maze, EA; et al. The HIV-1 Antisense Protein (ASP) induces CD8 T cell responses during chronic infection. RETROVIROLOGY 12:-(2015).
    Sritharan, N; Choudhury, M; et al. Highly immunoreactive antibodies against the rHup-F2 fragment (aa 63-161) of the iron-regulated HupB protein of Mycobacterium tuberculosis and its potential for the serodiagnosis of extrapulmonary and recurrent tuberculosis. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 34:33-40(2015).

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