Jag1
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Official Full Name
jagged 1
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Overview
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor Notch-1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. -
Synonyms
Jagged1; JAG1; AGS; AHD; AWS; CD339; HJ1; JAGL1; jagged 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus monkey
- CHO
- E.coli
- HEK293
- HEK293T
- Human Cell
- Mammalian Cell
- Mammalian cells
- NS0
- C
- 6×His
- Fc
- His
- Myc
- DDK
- Flag
- hFc
- hIgG1
- hIgG4
- His (Fc)
- Avi
- His|SUMO|Myc
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Jag1 Related Articles
- Jag1 Related Research Area
Jag1 involved in several pathways and played different roles in them. We selected most pathways Jag1 participated on our site, such as Activated NOTCH1 Transmits Signal to the Nucleus, Constitutive Signaling by NOTCH1 HD Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, which may be useful for your reference. Also, other proteins which involved in the same pathway with Jag1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Activated NOTCH1 Transmits Signal to the Nucleus | JAG1;ADAM10;JAG2;DTX2;MIB1;CNTN1;DLK1;DNER |
Constitutive Signaling by NOTCH1 HD Domain Mutants | JAG1;ADAM10;MIB1;JAG2 |
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | HDAC6;MIB1;HEY1;HEY2;JAG1;HDAC5;JAG2;ADAM10;CCNC |
Constitutive Signaling by NOTCH1 PEST Domain Mutants | CCNC;ADAM10;MIB1;JAG2;JAG1;CDK8;HDAC6;HEYL;HEY1 |
Constitutive Signaling by NOTCH1 t(7 | JAG2;JAG1 |
9)(NOTCH1:M1580_K2555) Translocation Mutant | JAG2;JAG1 |
Delta-Notch Signaling Pathway | YY1;ASCL1A;ZFPM1;JAG1;RING1;WDR12;MAGEA1;NOV;CNTFR |
Disease | CCDC167;KPNA5;MMADHC;NUPL2;AP2A1;PSIP1;CTDP1;FDXR;KERA |
Diseases of signal transduction | CTBP2;TNKS;TRIM24;FKBP1A;DERL2;HEY2;MYO18A;HEY1;TNKS2 |
Jag1 has several biochemical functions, for example, Notch binding, calcium ion binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Jag1 itself. We selected most functions Jag1 had, and list some proteins which have the same functions with Jag1. You can find most of the proteins on our site.
Function | Related Protein |
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Notch binding | NOTCH1;NOV;NOTCH4;GALNT11;JAG1;DLL4;AAK1;C8orf4;DLL1 |
calcium ion binding | SLC25A23;PCDHB11;CABP1;AKR1C1;ITSN2A;BGLAP;C1R;PCDHGC4;C2CD4A |
growth factor activity | INHA;MANF;BMP7A;NUDT6;REG1A;FGF6A;GFER;GDF10;BMP1 |
protein binding | CHN2;DNMT3L;MYO6;PRKD1;EHD3;STAP2;DPP3;GABPA;KRTAP23-1 |
structural molecule activity | CLDN15;CLDN18;COPB2;COPE;INAB;SPRR2A;CLDN7A;LMNL3;CLDN19 |
Jag1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Jag1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Jag1.
CD46; NOTCH1; ADAM17; NOTCH3; mdtB; argS; CALR; CANX
- Q&As
- Reviews
Q&As (5)
Ask a questionUnderstanding the role of JAG1 in tissue regeneration and repair may lead to advances in regenerative medicine by promoting controlled cell differentiation.
Yes, genetic testing can be performed to identify JAG1 mutations in individuals suspected of having Alagille syndrome or related conditions.
Currently, there are no specific targeted therapies for JAG1-related conditions. Treatment typically focuses on managing symptoms and complications.
Some clinical trials may be exploring therapies or treatments related to JAG1 in the context of specific medical conditions, but it's essential to check for the most up-to-date information.
Yes, JAG1 is being investigated as a potential target for cancer therapy, as its role in the Notch pathway can influence cell proliferation and tumor growth.
Customer Reviews (3)
Write a reviewWhen used in Western blotting experiments, the JAG1 protein produces distinct protein bands, allowing for easy visualization and interpretation.
Its resistance to degradation and denaturation allows for longer storage times and repeated use without compromising its performance or functionality.
JAG1 protein is known for its stability and robustness, making it suitable for a wide range of experimental conditions.
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