met
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  • Official Full Name
  • met proto-oncogene
  • Background
  • The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MET; met proto-oncogene; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase;
Cat.#:MET-1624HATag:Fc|His
Source (Host):NS0 CellsSpecies:Human
Product nameRecombinant Human MET protein, Fc-His-tagged, APC labeled
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Cat.#:MET-1624HPTag:Fc|His
Source (Host):NS0 CellsSpecies:Human
Product nameRecombinant Human MET protein, Fc-His-tagged, R-PE labeled
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Cat.#:Met-1744MATag:Fc|His
Source (Host):Sf 21 Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Met protein, Fc-His-tagged, APC labeled
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Cat.#:Met-1744MPTag:Fc|His
Source (Host):Sf 21 Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Met protein, Fc-His-tagged, R-PE labeled
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Cat.#:MET-183CATag:Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus MET protein, Fc-tagged, APC labeled
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Cat.#:MET-183CPTag:Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus MET protein, Fc-tagged, R-PE labeled
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Cat.#:MET-196HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human MET protein, Fc-tagged, APC labeled
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Cat.#:MET-196HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human MET protein, Fc-tagged, R-PE labeled
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Cat.#:Met-31HATag:Fc|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Met protein, Fc-His-tagged, APC labeled
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Cat.#:Met-31HPTag:Fc|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Met protein, Fc-His-tagged, R-PE labeled
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Cat.#:MET-382RATag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat MET protein, Fc-tagged, APC labeled
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Cat.#:MET-382RPTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat MET protein, Fc-tagged, R-PE labeled
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Cat.#:Met-4061MATag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Met protein, Fc-tagged, APC labeled
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Cat.#:Met-4061MPTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Met protein, Fc-tagged, R-PE labeled
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Cat.#:Met-730MATag:Fc
Source (Host):Murine myeloma cellline, NS0-derived.Species:Mouse
Product nameRecombinant Mouse Met protein, Fc-tagged, APC labeled
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Cat.#:Met-730MPTag:Fc
Source (Host):Murine myeloma cellline, NS0-derived.Species:Mouse
Product nameRecombinant Mouse Met protein, Fc-tagged, R-PE labeled
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Cat.#:MET-382HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MET Protein, His-tagged
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Cat.#:MET-4419HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MET Protein, GST-tagged
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Cat.#:MET-4420HTag:GST|His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human MET Protein, GST/His-tagged
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Cat.#:MET-5452HTag:GST|His
Source (Host):Sf9 insect cellsSpecies:Human
Product nameRecombinant Human Met Proto-Oncogene (hepatocyte growth factor receptor), GST-His-tagged
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Cat.#:MET-947HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MET Protein, MYC/DDK-tagged
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Cat.#:Met-4417RTag:N/A
Source (Host):Insect cellSpecies:Rat
Product nameRecombinant Rat Met Protein
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Cat.#:MET-1624HTag:Fc|His
Source (Host):NS0Species:Human
Product nameRecombinant Human MET, Fc-His
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Cat.#:MET-2394HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MET
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Cat.#:MET-353HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MET, GST-tagged, Active
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Cat.#:Met-1744MTag:Fc
Source (Host):Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Met Proto-oncogene, Fc-His
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Cat.#:Met-194HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Met, His tagged
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Cat.#:MET-195HTag:His|Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human MET Protein, His & Avi-tagged, Biotinylated
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Cat.#:MET-196HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human MET Protein, Fc-tagged
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Cat.#:MET-202HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MET, His-tagged, C13&N15 Labeled
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Cat.#:MET-213HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MET, His-tagged
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Cat.#:MET-218HTag:DDK|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MET protein, DDK/His-tagged
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Cat.#:MET-237HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human MET, C13&N15-labeled
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Cat.#:MET-28602THTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MET
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Cat.#:MET-29606THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MET
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Cat.#:MET-29608THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MET
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Cat.#:MET-307HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MET
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Cat.#:Met-31HTag:Fc|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Met, Fc-His tagged
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Cat.#:MET-63HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MET, GST-tagged
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Cat.#:MET-64HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human MET protein, Flag-tagged, Biotinylated
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Cat.#:MET-65HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MET Mutant (V1092I), GST-tagged
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Cat.#:MET-66HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MET Mutant (T1173I), GST-tagged
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Cat.#:MET-67HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MET Mutant (F1200I), GST-tagged
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Cat.#:MET-68HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MET Mutant (D1228H), GST-tagged
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Cat.#:MET-69HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MET Mutant (Y1230C), GST-tagged
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Cat.#:MET-70HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MET Mutant (Y1230D), GST-tagged
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Cat.#:MET-71HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MET Mutant (Y1230H), GST-tagged
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Cat.#:MET-7295HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MET, His & GST tagged
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Cat.#:MET-72HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MET Mutant (Y1235D), GST-tagged
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Cat.#:MET-84HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MET Mutant (D1228N), GST-tagged
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Cat.#:Met-4061MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Met, Fc tagged
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Cat.#:Met-4062MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Met, His tagged
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Cat.#:Met-8335MTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Met
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Cat.#:MET-3653RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MET Protein
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Cat.#:MET-382RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Met, Fc tagged
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Cat.#:MET-182CTag:N/A
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus MET
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Cat.#:MET-183CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus MET, Fc-tagged
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Cat.#:MET-184CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus MET, His-tagged
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Cat.#:MET-2734RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MET Protein, His-tagged
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Cat.#:MET-1037CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine MET Protein, His-tagged
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Cat.#:MET-6765CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MET
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Cat.#:MET-1642ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MET
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Cat.#:Met-730MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Met Proto-Oncogene, Fc-tagged
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Cat.#:MET-1271HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Met Proto-Oncogene (hepatocyte growth factor receptor), GST-tagged
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Cat.#:MET-1272HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Met Proto-Oncogene (hepatocyte growth factor receptor), His-tagged
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Cat.#:Met-1060RTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Rat
Product nameRecombinant Rat Met Proto-Oncogene, GST-tagged
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Cat.#:MET-001HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MET cell lysate
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Cat.#:MET-2529HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human MET cell lysate
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Cat.#:MET-2047MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse MET cell lysate
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Cat.#:MET-1054RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat MET cell lysate
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Cat.#:MET-001CCLTag:N/A
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus MET cell lysate
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Cat.#:MET-1931CCLTag:N/A
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine MET cell lysate
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Cat.#:Kit-0550Tag:N/A
Source (Host):Species:
Product nameMet Kinase (Human) Assay/Inhibitor Screening Assay Kit
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Involved Pathway

MET involved in several pathways and played different roles in them. We selected most pathways MET participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MET were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
GRIN2B; CALML3; CALM2; PLCG2; GNGT1; KIT; PDGFC; MET; PIK3CD; TBK1
Rap signaling pathway
FGF3; DOCK4; FGF5; CDH1; FGFR2; MAPK1; RAP1GAP; FLT1; PRKD3; MAP2K6
Cytokine-cytokine receptor interaction
IL6; TNFRSF13C; CD40; IFNAR1; LIF; PRLRA; ACVR2A; IFNAR2; OSM; THPO
Endocytosis
SH3GLB1B; RAB11BB; CAPZA1; WIPF2; FAM125B; CYTH2; PIP5K1A; ADRBK2; STAMBPA; STAM
PIK-Akt signaling pathway
PPP2R5B; YWHAH; NOS3; BCL2L1; CASP9; SYK; TRP53; PPP2R2C; ITGA3; TEK
Axon guidance
PAQR3B; FRS3; GNAI3; DPYSL5A; RHOA; ROBO1; DUSP6; CXCR4; KCNQ2; UNC5C
Focal adhesion
MYLPFB; ITGB1A; RAC3A; PPP1R12B; TNC; ACTN3B; PPP1R12C; TNXB; DIAP1; COMP
Adherens junction
WASF3; ACTN3; ACTN3B; WASF1; WASL; RAC2; ACTB1; PTPRFB; SSX2IP; SMAD2
Bacterial invasion of epithelial cells
PIK3CA; PIK3R2; ARPC1A; CRK; ARPC2; HCLS1; CRKL; CBLB; SEPT12; BCAR1
Epithelial cell signaling in Helicobacter pylori infection
PLCG1; TCIRG1; MAPK12; ATP6V1C1; IL-8; ATP6V0C; ATP6V1F; ATP6V1B1; JAM3; ATP6V0A2
Malaria
GYPC; IL-8; DARC; SDC2; LRP1; CD36; CD81; SELE; THBS4; ITGB2
Pathways in cancer
Fasl; COL4A1; LPAR6; NFKBIA; CXCL12; BDKRB2; PDGFRB; ABL1; FGF12; GRB2
Transcriptional misregulation in cancer
MEN1; NFKBIZ; DOT1L; BCL2L1; TLX3; NTRK1; SSX2; CDK14; IGF1; IL6
Proteoglycans in cancer
PDPK1; Fzd4; CDC42; PDCD4; HGF; WNT2B; FZD9; PTCH1; PLAUR; FZD6
MicroRNAs in cancer
ABL1; DICER1; VEGFA; PLCG1; ABCB1A; CCND2; PLAU; RPS6KA5; RHOA; RASSF1
Renal cell carcinoma
CDC42; RAP1A; RAPGEF1; ARNT; AHA-1; TGFB1; TGFB3; FH; TCEB2; BRAF
Melanoma
FGF5; TP53; PDGFD; FGF10; FGF6; MET; PIK3CB; FGF21; Fgf15; FGF12
Central carbon metabolism in cancer
RAF1; PKM2; SIRT6; NRAS; HK3; PDGFRB; MTOR; PIK3R3; PFKM; PDGFRA

Protein Function

MET has several biochemical functions, for example, ATP binding, hepatocyte growth factor-activated receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MET itself. We selected most functions MET had, and list some proteins which have the same functions with MET. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UCK2B; FGFR1; UBE2IA; RAD51C; PTK7; TTLL9; DCKL1B; CDK13; ARAF; UBA2
Function hepatocyte growth factor-activated receptor activity
Related Protein MET
Function protein binding
Related Protein FIBCD1; TRAF3IP3; DERL1; IRX1; NKX2; LPA; DOCK2; SNAPIN; PLAT; AURKAIP1
Function protein phosphatase binding
Related Protein DLG4; MVP; EGFR; FGF19; PPP1R3G; NEK2; PPP1R3C; PPP6R1; MET; VCAN
Function protein tyrosine kinase activity
Related Protein ERBB2; CLK2; FGFR2; KDRL; EPHB2; EPHB3A; INSR; CLK4; MAP2K3; FGFR1OP

Interacting Protein

MET has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MET here. Most of them are supplied by our site. Hope this information will be useful for your research of MET.
CBL; PLXNB1

MET Related Articles

Gargalionis, AN; Korkolopoulou, P; et al. Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer. INTERNATIONAL JOURNAL OF CANCER 136:1515-1527(2015).
Bernstein, DI; Atmar, RL; et al. Norovirus Vaccine Against Experimental Human GII.4 Virus Illness: A Challenge Study in Healthy Adults. JOURNAL OF INFECTIOUS DISEASES 211:870-878(2015).