| Official Full Name | matrix metallopeptidase 3 (stromelysin 1, progelatinase) |
| Background | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] |
| Synonyms | MMP3; matrix metallopeptidase 3 (stromelysin 1, progelatinase); SL-1; STMY; STR1; CHDS6; MMP-3; STMY1; stromelysin-1; transin-1; proteoglycanase; matrix metalloproteinase-3; matrix metalloproteinase 3 (stromelysin 1, progelatinase) |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
MMP3 involved in several pathways and played different roles in them. We selected most pathways MMP3 participated on our site, such as TNF signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TNF signaling pathway | FAS; PIK3R3; PIK3CA; TNFAIP3; FOS; AKT1; NFKBIA; MAGI2; IKBKG; MAP2K6 |
| Transcriptional misregulation in cancer | HOXA9; IL1R2; H3F3C; Bcl2a1b; BCL6; PTK2; NUPR1; MAX; IL-8; FCGR1 |
| Rheumatoid arthritis | TEK; ATP6V0E2; ITGB2; IFNG; ATP6V0E; MMP1A; HLA-DQB1; CCL3L1; TNFSF11; HLA-DRB5 |
MMP3 has several biochemical functions, for example, calcium ion binding, endopeptidase activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP3 itself. We selected most functions MMP3 had, and list some proteins which have the same functions with MMP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | FLG; DHH; RASGRP2; PCDH1G11; OVAL; REPS1; CAPN3B; PPEF1; LDLRB; ANXA3B |
| endopeptidase activity | APH1B; SENP3; TPP1; HTRA4; NAPSA; SENP1; ACE2; PSMA3; FURIN; PSMB8 |
| metalloendopeptidase activity | MEP1A; UQCRC2; MMP12; C6AST1; ADAMDEC1; MEP1A.1; ADAM33; Adam6; MMP13A; MMP14 |
| protein binding | RAD51; ERC2; CCDC88A; UFD1L; KLK6; ID1; PSMD5; DPCD; BCL2L13; C19orf47 |
| zinc ion binding | ADAM1B; KDM7AB; PHF8; RXRB; SF3A2; KCMF1; ZDHHC14; P2RX4; LTA4H; ESRRGB |
MMP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP3.
MEOX2; TIMP1
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