Recombinant Human Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase), GST-Tagged
Cat.No. : | MMP3-1383H |
Product Overview : | MMP-3 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain fused to a GST tag containing 228 amino acids (251-478) and having a total molecular mass of 51kDa. MMP-3 is purified by proprietary chromatographic techniques. |
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Cat. No. : | MMP3-1383H |
Description : | MMP-3 enzyme is also known as Stromelysin-1or as Transin-1 which hydrolyzes natural collagen at physiological pH and temperature. It dissolves the intervertebral nucleus pulposus and annulus fibrosus of Herniated Lumbar Intervertebral Disk . MMP-3 hydrolyzes components of the extracellular matrix like proteoglycan, laminin, fibronectin, gelatin and collagen types III, IV and IX. It also activates pro-MMP-9 and pro-MMP-8 and superactivates plasmin activated MMP-1. MMP-3 is secreted as a latent proenzyme and is activated by a variety of proteinases, e.g. plasmin, trypsin, chymotrypsin, cathepsin G or human neutrophil elastase. MMP-3 was found to be capable of activating the precursor of IL1-beta. |
Source : | Human |
Host : | Escherichia Coli. |
Form : | MMP-3 is supplied in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol. |
Physical Appearance : | Sterile Filtered clear solution. |
Storage : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. |
Protein length : | 251-478 |
Gene Name : | MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) [ Homo sapiens ] |
Official Symbol : | MMP3 |
Synonyms : | MMP3; matrix metallopeptidase 3 (stromelysin 1, progelatinase); SL-1; STMY; STR1; CHDS6; MMP-3; STMY1; MGC126102; MGC126103; MGC126104; stromelysin-1; transin-1; proteoglycanase; OTTHUMP00000045949; matrix metalloproteinase-3; matrix metalloproteinase 3 (stromelysin 1, progelatinase); Stromelysin-1; Matrix metalloproteinase-3; Transin-1; EC 3.4.24 |
Gene ID : | 4314 |
mRNA Refseq : | NM_002422 |
Protein Refseq : | NP_002413 |
MIM : | 185250 |
UniProt ID : | P08254 |
Chromosome Location : | 11q22.3 |
Pathway : | Matrix Metalloproteinases; Rheumatoid arthritis; p75(NTR)-mediated signaling |
Function : | calcium ion binding; metalloendopeptidase activity; peptidase activity; protein complex binding; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
MMP3-0029H | Recombinant Human MMP3 Protein | +Inquiry |
MMP3-1123H | Recombinant Human MMP3 Protein, His-tagged | +Inquiry |
Mmp3-10594M | Recombinant Mouse Mmp3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Mmp3-7422R | Recombinant Rat Mmp3 protein, His-tagged | +Inquiry |
MMP3-5433H | Recombinant Human MMP3 Protein, GST-tagged | +Inquiry |
◆ Native Protein | ||
MMP3-26C | Native Clostridium histolyticum Collagenase Type 3 Protein | +Inquiry |
◆ Lysates | ||
MMP3-4273HCL | Recombinant Human MMP3 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2213 | MMP-3 Activity Fluorometric Assay Kit | +Inquiry |
Kit-0589 | MMP-3 Activity Assay Kit | +Inquiry |
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Not For Human Consumption!
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Q&As (7)
Ask a questionMMP3 breaks down extracellular matrix components, aiding in tissue remodeling and repair.
MMP3 facilitates cancer metastasis by altering the tumor microenvironment and promoting invasion.
Changes in MMP3 activity can accelerate skin aging and contribute to dermatological conditions.
MMP3 influences cardiovascular health by affecting arterial wall remodeling and stability.
MMP3 contributes to arthritis progression by degrading joint cartilage and connective tissues.
MMP3 modulates inflammation, impacting tissue inflammation and repair processes.
MMP3 plays a role in wound healing by remodeling damaged tissues and aiding in repair.
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