stat1
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  • Official Full Name
  • signal transducer and activator of transcription 1, 91kDa
  • Background
  • The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors,;STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that;translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various;ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a;variety of genes, which is thought to be important for cell viability in response to different cell stimuli and;pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
  • Synonyms
  • STAT1; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1-alpha/beta; ISGF 3; STAT91; transcription factor ISGF 3 components p91/p84; transcription factor ISGF-3 components p91/p84; signal transducer and activator of transcription-1; CANDF7; ISGF-3; DKFZp686B04100
Cat.#:STAT1-2901HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human STAT1 Protein, MYC/DDK-tagged
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Cat.#:STAT1-040HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT1 Protein
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Cat.#:STAT1-1164HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human STAT1
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Cat.#:STAT1-2996HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT1, GST-tagged
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Cat.#:STAT1-30902THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT1
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Cat.#:STAT1-30903THTag:
Source (Host):Species:Human
Product nameRecombinant Human STAT1
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Cat.#:STAT1-331HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT1 protein, His/MBP-tagged
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Cat.#:STAT1-4885HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Signal Transducer And Activator Of Transcription 1, 91kDa, GST-tagged
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Cat.#:STAT1-7037HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human STAT1, His & GST tagged
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Cat.#:STAT1-73HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT1, no tag
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Cat.#:STAT1-8473HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human STAT1, His-tagged
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Cat.#:Stat1-1733MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Stat1 protein, His & T7-tagged
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Cat.#:STAT1-4516RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey STAT1 Protein, His-tagged
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Cat.#:STAT1-2129CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken STAT1
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Cat.#:STAT1-2783HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT1, His-tagged
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Cat.#:STAT1-555HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human STAT1 cell lysate
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Involved Pathway

STAT1 involved in several pathways and played different roles in them. We selected most pathways STAT1 participated on our site, such as Chemokine signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chemokine signaling pathway
GRK1; SHC3; BCAR1; GM13304; XCL1; Cxcl15; Ccl9; CCL13; JAK2; GRK6
Osteoclast differentiation
MAPK12; FCGR3A; TNF; STAT1; FOS; PPARG; TNFRSF11A; TNFSF11; NCF2; TREM2
Toll-like receptor signaling pathway
IFNA10; RAC1B; IFNA1; IL12B; LY96; IRAK4; MAP3K7; PIK3CA; IL1B; RELA
Jak-STAT signaling pathway
IL12RB2; SOCS1; STAT3; FHL1; IL20RA; IL12BA; IL15; AOX1; IL23R; Il6ra
Prolactin signaling pathway
PIK3R5; ESR2; PIK3R3; CCND1; STAT1; SOCS2; CSH; MAPK12; HRAS; SHC1
Thyroid hormone signaling pathway
THRA; CCND1; PIK3R1; MED27; ITGAV; STAT1; SLC2A1; PRKACA; MTOR; NOTCH2
Leishmaniasis
PTPN6; IL12A; TGFB2; HLA-DQA1; FCGR1; TRAF6; H2-AA; NFKBIA; FCGR1A; HLA-DQB1
Toxoplasmosis
HSPA6; HLA-DMA; AKT2; H2-AB1; CYCS; RELA; Casp3; H2-AA; IL10RA; HSPA2
Tuberculosis
CYCS; CAMK2G; MAPK3; IL1A; IRAK4; Itgam&Itgb2; PLK3; ATP6V0B; IFNA5; CALM2
Hepatitis C
NR1H3; TRP53; STAT1; RAF1; CLDN7; MAVS; SCARB1; PIK3CB; IFIT1; IRF3
Hepatitis B
STAT3; OSTN; MAP2K2; CREB3L1; HSPG2; STAT2; TBK1; APAF1; IKBKE; AKT1
Measles
PIK3R3; IL1A; IRF7; Ifna15; NFKB1; IFNA17; IRF3; TYK2; IFNG; BBC3
Influenza A
FASLG; TLR4; PIK3CA; PRKCA; HSPA1A; ACTG1; MAPK1; TLR3; IFNA3; CCL5
Herpes simplex infection
HNRNPK; HLA-DRB5; PML; SRSF1A; NFKBIAA; CCL2; NXF3; BMA1; IRF7; PER1
Pathways in cancer
RHOA; GNGT2; MMP1A; LPAR6; PRKCG; SMO; GNA11; BCR; MITF; AXIN1
Pancreatic cancer
RB1; STAT1; RALBP1; RALGDS; BRCA2; AKT2; PIK3CD; SMAD4; TGFB2; MAPK10
Inflammatory bowel disease (IBD)
IL18R1; IL12B; TLR5; NFATC1; HLA-DRA; TBX21; IL1A; Il2; TNF; RORC

Interacting Protein

STAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT1.
STAT2; IFNGR1; EGFR

STAT1 Related Articles

Li, J; Jie, HB; et al. PD-1/SHP-2 Inhibits Tc1/Th1 Phenotypic Responses and the Activation of T Cells in the Tumor Microenvironment. CANCER RESEARCH 75:508-518(2015).
Matsushita, H; Hosoi, A; et al. Cytotoxic T Lymphocytes Block Tumor Growth Both by Lytic Activity and IFN gamma-Dependent Cell-Cycle Arrest. CANCER IMMUNOLOGY RESEARCH 3:26-36(2015).

STAT1 Related Gene Family

Cytokines