tgfbr2
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  • Official Full Name
  • transforming growth factor, beta receptor II (70/80kDa)
  • Background
  • This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TGFBR2; transforming growth factor, beta receptor II (70/80kDa); AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; TGF-beta receptor type-2; tbetaR-II; TGF-beta type II receptor; TGF-beta receptor type IIB; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II gamma; transforming growth factor, beta receptor II epsilon;
Cat.#:TGFBR2-377HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TGFBR2 Protein (Met1-Gln166), His-tagged
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Cat.#:TGFBR2-159HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2 Protein, Fc tagged
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Cat.#:TGFBR2-703HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2 Protein, MYC/DDK-tagged
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Cat.#:TGFBR2-151HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2, Fc Chimera
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Cat.#:TGFBR2-152HTag:Fc|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2, Fc-His tagged
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Cat.#:TGFBR2-1684HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Transforming Growth Factor, Beta Receptor II (70/80kDa)
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Cat.#:TGFBR2-229HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2 protein, Fc-tagged
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Cat.#:TGFBR2-444HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TGFBR2, GST-tagged, Active
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Cat.#:TGFBR2-646HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human TGFBR2, Fc Chimera
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Cat.#:TGFBR2-697HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TGFBR2, Fc-tagged, Biotinylated
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Cat.#:Tgfbr2-1778MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Transforming Growth Factor, Beta Receptor II
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Cat.#:Tgfbr2-8188MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tgfbr2 protein, His & T7-tagged
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Cat.#:TGFBR2-6039RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TGFBR2 Protein
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Cat.#:Tgfbr2-8722RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Tgfbr2, Fc tagged
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Cat.#:TGFBR2-8814CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TGFBR2, Fc tagged
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Cat.#:TGFBR2-4689RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TGFBR2 Protein, His-tagged
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Cat.#:TGFBR2-6979CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TGFBR2
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Cat.#:TGFBR2-9644ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TGFBR2
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Cat.#:TGFBR2-923HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta Receptor II (70/80kDa)
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Cat.#:TGFBR2-2842HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2 cell lysate
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Cat.#:TGFBR2-1374RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat TGFBR2 cell lysate
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Cat.#:TGFBR2-1291CCLTag:N/A
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TGFBR2 cell lysate
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Involved Pathway

TGFBR2 involved in several pathways and played different roles in them. We selected most pathways TGFBR2 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
SOS1; MOS; FGF13A; PPP3CCB; FAS; GNA12; TGFB3; FGF12A; MKNK1; MAPKAPK5
Cytokine-cytokine receptor interaction
Il6ra; Il2; IL12RB1; TNFSF15; CSH; CXCL2; TNFSF18; IFNA7; CCL19B; CD70
FoxO signaling pathway
BNIP3; PRKAG2A; BCL6A; MAP2K2; GABARAP; MAPK8; FOXO3B; PIK3CD; PRKAG3; PLK2B
Endocytosis
PDCD6IP; CSF1RA; SMAP2; ARPC5LA; EHD1A; RAB11FIP5; FAM125B; VPS26B; TFR1A; DNM2B
TGF-beta signaling pathway
ZFYVE16; BMPR1B; TFDP1; NODAL; BMPR1AA; ID4; TGIF2; RPS6KB2; ACVR2B; ROCK1
Osteoclast differentiation
TEC; IL1A; TAB2; PIK3R3; MAPK12; PIK3R1; TYROBP; MAPK11; NFATC2; MAPK1
Hippo signaling pathway
PARD6A; GLI2; BMP7; ID1; PRKCI; TGFB3; WNT9A; PPP1CB; WWC1; APC2
Adherens junction
PTPN6; RAC3A; CDC42L2; PTPRM; FER; CDC42L; RAC1A; TJP1; BAIAP2A; PARD3
Chagas disease (American trypanosomiasis)
TGFB1; BDKRB2; LOC100033925; C1QC; GNAI1; PIK3R2; GNAQ; CD3G; TICAM1; AKT1
HTLV-I infection
XPO1; TNFRSF1A; HLA-DRA; TP53; CD3D; PCNA; NFATC1; NRAS; RANBP3; ATF4
Pathways in cancer
GNAS; RARB; HDAC1; MAP2K2; ITGB1; TCEB2; BIRC8; AGTR1B; BAD; Casp3
Transcriptional misregulation in cancer
MPO; HIST2H3C2; ZEB1; SSX1; TLX1; BCL2A1A; ZBTB17; IGFBP3; HIST1H3G; ETV7
Colorectal cancer
AXIN1; SMAD3; PIK3R2; BCL2; PIK3CA; PIK3R3; LEF1; BAD; TCF7; TRP53
Pancreatic cancer
MAPK9; CDC42; AKT2; RAD51; PIK3R2; IKBKB; TGFB3; RAC2; IKBKG; TGFA
Chronic myeloid leukemia
PIK3R3; RB1; IKBKG; SHC4; KRAS; RELA; PIK3CD; TP53; MAPK1; SHC1

Protein Function

TGFBR2 has several biochemical functions, for example, ATP binding, SMAD binding, glycosaminoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR2 itself. We selected most functions TGFBR2 had, and list some proteins which have the same functions with TGFBR2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein GPHN; PRKCBA; BTK; IP6K3; PRKX; MATK; CSNK2A2; KIF3A; CAMKVB; PKN1
Function SMAD binding
Related Protein TGFBR3; BMPR1B; SKOR1A; BMP2; SKOR1; ACVRL1; MAGI2; PRDM16; SOD3; TGFBRAP1
Function glycosaminoglycan binding
Related Protein TGFBR2; PODXL2; NDNF; SERPINA5; VIT; CCDC80; EGFLAM; DCN; SPOCK2; Shh
Function metal ion binding
Related Protein ZNF501; ZBED3; SMAD6; CYP2P9; NQO2; ZFPM2A; DMRTA1; ZNF16; ZFP668; BMPR2
Function protein binding
Related Protein IPO4; GPI1; MAP3K7; GLI2; DOCK10; NKG7; TNNT1; UVRAG; PYY; ZFP523
Function receptor signaling protein serine/threonine kinase activity
Related Protein SBK3; TGFBR2; BMPR2A; BMPR2B; ACVR1B; ACVR1BA; ACVR2A; BMPR1B; STK24B; ACVR1C
Function transforming growth factor beta binding
Related Protein ENG; TGFBR1; TGFBR2; LTBP1; TGFBR3; LTBP4; CD109; VASN; THBS1; ITGAV
Function contributes_to transforming growth factor beta binding
Related Protein ENG; TGFBR2; TGFBR1; TGFBR3
Function transforming growth factor beta receptor activity, type II
Related Protein AMHR2; TGFBR2
Function transforming growth factor beta-activated receptor activity
Related Protein TGFBR2; ACVRL1; BMPR2B; BMPR2A; TGFBR3; ENG; TGFBR1; LTBP1
Function transmembrane receptor protein serine/threonine kinase activity
Related Protein BMPR1AB; ACVRL1; BMPR1AA; TGFBR2; BMPR1B; BMPR1A; ACVR2A; TGFBR1B; BMPR2B; ACVR1L
Function type I transforming growth factor beta receptor binding
Related Protein SMAD2; SMAD7; FKBP1A; SMAD6; ENG; SNX25; TGFBR2; TGFB3; TGFB1
Function type III transforming growth factor beta receptor binding
Related Protein TGFBR2; TGFB2; TGFB3; TGFB1

Interacting Protein

TGFBR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR2.
TGFB1; TGFB3; SCUBE3

TGFBR2 Related Gene Family

TGF