tgfbr2
Share
  • Official Full Name
  • transforming growth factor, beta receptor II (70/80kDa)
  • Background
  • This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TGFBR2; transforming growth factor, beta receptor II (70/80kDa); AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; TGF-beta receptor type-2; tbetaR-II; TGF-beta type II receptor; TGF-beta receptor type IIB; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II gamma; transforming growth factor, beta receptor II epsilon;
Cat.#:TGFBR2-377HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TGFBR2 Protein (Met1-Gln166), His-tagged
+Inquiry
Cat.#:TGFBR2-159HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2 Protein, Fc tagged
+Inquiry
Cat.#:TGFBR2-703HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:TGFBR2-151HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2, Fc Chimera
+Inquiry
Cat.#:TGFBR2-152HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2, Fc-His tagged
+Inquiry
Cat.#:TGFBR2-1684HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Transforming Growth Factor, Beta Receptor II (70/80kDa)
+Inquiry
Cat.#:TGFBR2-229HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2 protein, Fc-tagged
+Inquiry
Cat.#:TGFBR2-444HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TGFBR2, GST-tagged, Active
+Inquiry
Cat.#:TGFBR2-646HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human TGFBR2, Fc Chimera
+Inquiry
Cat.#:TGFBR2-697HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TGFBR2, Fc-tagged, Biotinylated
+Inquiry
Cat.#:Tgfbr2-1778MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Transforming Growth Factor, Beta Receptor II
+Inquiry
Cat.#:Tgfbr2-8188MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tgfbr2 protein, His & T7-tagged
+Inquiry
Cat.#:TGFBR2-6039RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TGFBR2 Protein
+Inquiry
Cat.#:Tgfbr2-8722RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Tgfbr2, Fc tagged
+Inquiry
Cat.#:TGFBR2-8814CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TGFBR2, Fc tagged
+Inquiry
Cat.#:TGFBR2-4689RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TGFBR2 Protein, His-tagged
+Inquiry
Cat.#:TGFBR2-6979CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TGFBR2
+Inquiry
Cat.#:TGFBR2-9644ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TGFBR2
+Inquiry
Cat.#:TGFBR2-923HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta Receptor II (70/80kDa)
+Inquiry
Cat.#:TGFBR2-2842HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2 cell lysate
+Inquiry
Cat.#:TGFBR2-1374RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat TGFBR2 cell lysate
+Inquiry
Cat.#:TGFBR2-1291CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TGFBR2 cell lysate
+Inquiry

Involved Pathway

TGFBR2 involved in several pathways and played different roles in them. We selected most pathways TGFBR2 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
TGFBR1B; HSPA1A; NLK; CASP3B; MAPK14B; RASA1; FGF14; FLNA; FGF17; PRKCBA
Cytokine-cytokine receptor interaction
CCL25; CCR8; CCL7; LTA; LTB; FLT3LG; IFNE; IL17RB; CX3CL1; CSH
FoxO signaling pathway
SGK2B; RAF1; MAP2K2; SGK2A; PRKAB1; AKT3A; FOXO6; IL7R; S1PR4; STAT3
Endocytosis
TRAF6; CYTH3; ARF6B; HSPA1A; CSF1RA; SNX1A; LDLRAP1; RLN1; KIT; ZFYVE20
TGF-beta signaling pathway
GDF5; BAMBI; RHOAB; ID1; ACVR1; TGFBR1; INHBE; LEFTY1; SPAW; NDR1
Osteoclast differentiation
MAP3K7; MAP3K14; IFNAR2; FCGR4; FOSL2; TYROBP; TGFB2; NFKB1; CAMK4; TNFRSF1A
Hippo signaling pathway
TGFB3; WNT2B; TCF7; AREG; WTIP; WWC1; PARD3; ACTB; FBXW11; WNT3
Adherens junction
FARP2; TCF7; RAC1A; ACTN3A; SMAD4; INSRB; WAS; FGFR1; CTNNA3; CSNK2A2
Chagas disease (American trypanosomiasis)
NFKBIA; PPP2R1B; IL10; PIK3R1; PIK3CB; C1QB; TGFB3; MAPK13; FASLG; MAP2K4
HTLV-I infection
FZD1; IL1R2; HLA-DRB5; RRAS2; MAP2K4; STAT5A; SLC25A6; PRKACB; SMAD3; WNT6
Pathways in cancer
MTOR; WNT8B; FGF10; ITGAV; SMO; GNG12; NRAS; RALGDS; ARNT2; WNT1
Transcriptional misregulation in cancer
TLX1; MEF2C; PPARG; FCGR1A; IL3; PFTK1; PER2; BCL2A1; TCF3; MLLT3
Colorectal cancer
KRAS; PIK3CB; APC2; TCF7L2; ARAF; BRAF; TRP53; PIK3CD; MLH1; Casp3
Pancreatic cancer
BAD; PIK3CD; MAP2K1; STAT1; MAPK1; MAPK9; PIK3R2; PIK3R5; BRCA2; CASP9
Chronic myeloid leukemia
TGFBR2; RUNX1; BCR; PIK3R5; PIK3R2; MECOM; SMAD3; HDAC1; NRAS; TGFBR1

Protein Function

TGFBR2 has several biochemical functions, for example, ATP binding, SMAD binding, glycosaminoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR2 itself. We selected most functions TGFBR2 had, and list some proteins which have the same functions with TGFBR2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein EIF4A1B; KIF2B; NLRC3; PANK2; STK38L; TK2; DDX18; DDR2; PRKCA; CAMK2D1
Function SMAD binding
Related Protein SKOR1; YY1; COL1A2; MEF2A; HMGA2; SMAD2; HIPK2; TGFBRAP1; AXIN1; MAGI2
Function glycosaminoglycan binding
Related Protein CCDC80; EGFLAM; SPOCK3; VCAN; TGFBR3; DCN; BGN; PODXL2; TGFBR2; SPOCK2
Function metal ion binding
Related Protein ENPP5; POMT1; FTH1B; STAC; CD209A; ZNF582; TIMP2; TOE1; ZNF550; MOBKL1A
Function protein binding
Related Protein ITK; SLC25A4; LIG4; TUBGCP4; DCDC2; SMARCB1; KLK6; GABARAPL1; VASNA; SH3GLB1
Function receptor signaling protein serine/threonine kinase activity
Related Protein STK24A; TGFBR1B; AMHR2; ACVR1L; TGFBR2; ACVR2AA; BMPR1AA; ACVR2B; TGFB2; OXSR1A
Function transforming growth factor beta binding
Related Protein THBS1; TGFBR1; ACVRL1; LTBP4; ACVR1; LTBP1; TGFBR2; CD109; VASN; HYAL2
Function contributes_to transforming growth factor beta binding
Related Protein TGFBR3; ENG; TGFBR1; TGFBR2
Function transforming growth factor beta receptor activity, type II
Related Protein TGFBR2; AMHR2
Function transforming growth factor beta-activated receptor activity
Related Protein ENG; TGFBR3; LTBP1; ACVRL1; BMPR2B; TGFBR2; TGFBR1; BMPR2A
Function transmembrane receptor protein serine/threonine kinase activity
Related Protein BMPR2B; ALPK2; BMPR1B; BMPR2A; ACVR1B; BMPR1AA; ACVR1; TGFBR1A; ACVR2AA; BMPR1BA
Function type I transforming growth factor beta receptor binding
Related Protein SNX25; FKBP1A; TGFB1; SMAD6; TGFB3; SMAD7; ENG; SMAD2; TGFBR2
Function type III transforming growth factor beta receptor binding
Related Protein TGFB3; TGFBR2; TGFB2; TGFB1

Interacting Protein

TGFBR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR2.
TGFB1; TGFB3; SCUBE3

TGFBR2 Related Gene Family

TGF