tgfbr2
Share
  • Official Full Name
  • transforming growth factor, beta receptor II (70/80kDa)
  • Background
  • This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TGFBR2; transforming growth factor, beta receptor II (70/80kDa); AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; TGF-beta receptor type-2; tbetaR-II; TGF-beta type II receptor; TGF-beta receptor type IIB; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II gamma; transforming growth factor, beta receptor II epsilon;
Cat.#:TGFBR2-377HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TGFBR2 Protein (Met1-Gln166), His-tagged
+Inquiry
Cat.#:TGFBR2-159HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2 Protein, Fc tagged
+Inquiry
Cat.#:TGFBR2-703HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:TGFBR2-151HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2, Fc Chimera
+Inquiry
Cat.#:TGFBR2-152HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2, Fc-His tagged
+Inquiry
Cat.#:TGFBR2-1684HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Transforming Growth Factor, Beta Receptor II (70/80kDa)
+Inquiry
Cat.#:TGFBR2-229HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2 protein, Fc-tagged
+Inquiry
Cat.#:TGFBR2-444HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TGFBR2, GST-tagged, Active
+Inquiry
Cat.#:TGFBR2-646HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human TGFBR2, Fc Chimera
+Inquiry
Cat.#:TGFBR2-697HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TGFBR2, Fc-tagged, Biotinylated
+Inquiry
Cat.#:Tgfbr2-1778MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Transforming Growth Factor, Beta Receptor II
+Inquiry
Cat.#:Tgfbr2-8188MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tgfbr2 protein, His & T7-tagged
+Inquiry
Cat.#:TGFBR2-6039RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TGFBR2 Protein
+Inquiry
Cat.#:Tgfbr2-8722RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Tgfbr2, Fc tagged
+Inquiry
Cat.#:TGFBR2-8814CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TGFBR2, Fc tagged
+Inquiry
Cat.#:TGFBR2-4689RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TGFBR2 Protein, His-tagged
+Inquiry
Cat.#:TGFBR2-6979CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TGFBR2
+Inquiry
Cat.#:TGFBR2-9644ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TGFBR2
+Inquiry
Cat.#:TGFBR2-923HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta Receptor II (70/80kDa)
+Inquiry
Cat.#:TGFBR2-2842HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2 cell lysate
+Inquiry
Cat.#:TGFBR2-1374RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat TGFBR2 cell lysate
+Inquiry
Cat.#:TGFBR2-1291CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TGFBR2 cell lysate
+Inquiry

Involved Pathway

TGFBR2 involved in several pathways and played different roles in them. We selected most pathways TGFBR2 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
RAF1B; STMN1; Pdgfa&Pdgfb; TP53; HSC70; ELK1; CACNA2D1; TRAF2; FGF13A; TAB2
Cytokine-cytokine receptor interaction
IL12RB1; MPL; CXCR5; EPO; IL15RA; GHRA; TNFSF18; IFNAR1; IL13; CCR6A
FoxO signaling pathway
TNFSF10; CDKN2D; MAP2K2B; FOXO3; PRKAB2; SGK2; KLF2B; CCNB1; NLK1; NRAS
Endocytosis
EHD2B; LDLRAP1B; ASAP2A; PLD1A; ARF6B; HRASA; ADRB1; CXCR4B; RAB7A; KIF5AA
TGF-beta signaling pathway
SMURF1; INHBC; TGIF1; TGFBR1; BMPR1BA; ID4; PPP2CB; TGFBR1B; RHOAB; IFNG1-2
Osteoclast differentiation
TRAF6; IFNG; BLNK; MAP2K6; TNFRSF11A; MAPK12; TREM2; ITGB3; MAPK3; cgr2b
Hippo signaling pathway
BMP6; ACTG1; FGF1; TP73; FZD10; APC; LATS1; SCRIB; SMAD7; WNT10B
Adherens junction
PARD3; TGFBR1; CTNND1; RHOA; RAC1A; TCF7; CSNK2A2A; PTPRJA; CSNK2A1; AASS
Chagas disease (American trypanosomiasis)
GNAI2; IL10; TGFB3; MAPK11; MAPK10; CCL5; PPP2R1B; AKT2; GNAO1; IL1B2
HTLV-I infection
AKT2; VCAM1; SMAD2; HLA-DOA; PTTG2; Adcy4; POLE3; PPP3CB; FDPS; SLC25A5
Pathways in cancer
RARB; VEGFC; ITGA6; TCEB1; WNT9B; MDM2; RASGRP3; PRKCB; AKT2; LAMA4
Transcriptional misregulation in cancer
ITGB7; CD14; PAX7; SPI1; ETV1; GRIA3; NCOR1; PAX5; SSX2; CCNA1
Colorectal cancer
AKT2; TGFBR1; MSH3; PIK3R3; RAF1; TRP53; APPL1; TGFBR2; ARAF; MAPK3
Pancreatic cancer
BRAF; MAPK3; RAD51; IKBKG; BCL2L1; CDC42; RAC1; AKT1; RB1; PIK3R3
Chronic myeloid leukemia
STAT5B; BAD; PIK3R5; TGFBR2; HDAC1; MECOM; PIK3CD; CBLB; SHC1; AKT2

Protein Function

TGFBR2 has several biochemical functions, for example, ATP binding, SMAD binding, glycosaminoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR2 itself. We selected most functions TGFBR2 had, and list some proteins which have the same functions with TGFBR2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NTRK3; Aatk; HIPK1; PSMC1A; FLT4; GART; PDS5B; NEK8; TRIO; ABCC8
Function SMAD binding
Related Protein HMGA2; PRDM16; HIPK2; ACVR1; COL1A2; SMURF2; SKOR1; BMPR1A; CTNNB1; TOB1
Function glycosaminoglycan binding
Related Protein SERPINE2; PODXL2; Shh; NDNF; VIT; BGN; VCAN; EGFLAM; TGFBR3; SERPINA5
Function metal ion binding
Related Protein SMYD2B; TDO2B; KCND1; FTR72; NT5C2B; IDS; ITGA9; PCK2; RCVRNA; MBLAC2
Function protein binding
Related Protein GYG1; GBP1; CLN3; PROM1; CBX8; GOLGA8G; FAM206A; TA; MYO7A; WASH1
Function receptor signaling protein serine/threonine kinase activity
Related Protein AMHR2; PAK2A; ACVR1BA; SBK3; ACVRL1; ACVR2A; PANK1A; BMPR2A; STK39; TGFBR1
Function transforming growth factor beta binding
Related Protein ACVRL1; TGFBR2; ENG; THBS1; ITGAV; CD109; LTBP4; ACVR1; LTBP1; TGFBR3
Function contributes_to transforming growth factor beta binding
Related Protein TGFBR2; ENG; TGFBR3; TGFBR1
Function transforming growth factor beta receptor activity, type II
Related Protein AMHR2; TGFBR2
Function transforming growth factor beta-activated receptor activity
Related Protein ENG; TGFBR1; ACVRL1; TGFBR2; TGFBR3; LTBP1; BMPR2B; BMPR2A
Function transmembrane receptor protein serine/threonine kinase activity
Related Protein ALPK2; BMPR1BA; ACVR2AA; ACVR1L; BMPR1A; ACVR1B; ACVR1BA; TGFBR1A; BMPR2A; BMPR1AA
Function type I transforming growth factor beta receptor binding
Related Protein SNX25; SMAD2; SMAD6; TGFB3; FKBP1A; ENG; SMAD7; TGFBR2; TGFB1
Function type III transforming growth factor beta receptor binding
Related Protein TGFB2; TGFBR2; TGFB1; TGFB3

Interacting Protein

TGFBR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR2.
TGFB1; TGFB3; SCUBE3

TGFBR2 Related Gene Family

TGF