tgfbr2
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  • Official Full Name
  • transforming growth factor, beta receptor II (70/80kDa)
  • Background
  • This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TGFBR2; transforming growth factor, beta receptor II (70/80kDa); AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; TGF-beta receptor type-2; tbetaR-II; TGF-beta type II receptor; TGF-beta receptor type IIB; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II gamma; transforming growth factor, beta receptor II epsilon;
Cat.#:TGFBR2-377HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TGFBR2 Protein (Met1-Gln166), His-tagged
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Cat.#:TGFBR2-159HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2 Protein, Fc tagged
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Cat.#:TGFBR2-703HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2 Protein, MYC/DDK-tagged
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Cat.#:TGFBR2-151HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2, Fc Chimera
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Cat.#:TGFBR2-152HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2, Fc-His tagged
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Cat.#:TGFBR2-1684HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Transforming Growth Factor, Beta Receptor II (70/80kDa)
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Cat.#:TGFBR2-229HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2 protein, Fc-tagged
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Cat.#:TGFBR2-444HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TGFBR2, GST-tagged, Active
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Cat.#:TGFBR2-646HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human TGFBR2, Fc Chimera
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Cat.#:TGFBR2-697HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TGFBR2, Fc-tagged, Biotinylated
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Cat.#:Tgfbr2-1778MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Transforming Growth Factor, Beta Receptor II
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Cat.#:Tgfbr2-8188MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tgfbr2 protein, His & T7-tagged
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Cat.#:TGFBR2-6039RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TGFBR2 Protein
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Cat.#:Tgfbr2-8722RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Tgfbr2, Fc tagged
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Cat.#:TGFBR2-8814CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TGFBR2, Fc tagged
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Cat.#:TGFBR2-4689RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TGFBR2 Protein, His-tagged
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Cat.#:TGFBR2-6979CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TGFBR2
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Cat.#:TGFBR2-9644ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TGFBR2
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Cat.#:TGFBR2-923HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta Receptor II (70/80kDa)
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Cat.#:TGFBR2-2842HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFBR2 cell lysate
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Cat.#:TGFBR2-1374RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat TGFBR2 cell lysate
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Cat.#:TGFBR2-1291CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TGFBR2 cell lysate
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Involved Pathway

TGFBR2 involved in several pathways and played different roles in them. We selected most pathways TGFBR2 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
IKBKG; IL1R2; MAP3K13; MYCB; CACNA1BA; KRAS; AKT2; PPM1NB; RELB; CACNB3A
Cytokine-cytokine receptor interaction
CLCF1; CXCR2; ACVR2B; BMPR2A; KITLGB; PDGFAA; CRFB16; IL12RB2; CD40; CCL20
FoxO signaling pathway
PIK3R3; EGFRA; HRAS; IRS2; FOXO3A; GRB2B; SMAD3A; SOD2; CCNB1; SGK2A
Endocytosis
EPN2; RHOA; RAB8A; VPS37A; RAB11BB; ASAP2A; STAMBP; DAB2; IL2RGA; ASAP2B
TGF-beta signaling pathway
ID2; BMPR1A; BMP8B; ID4; RHOA; ACVR2A; TGFBR2; NOG; INHBC; SMAD5
Osteoclast differentiation
RELA; CYLD; LILRA3; LILRB1; CALCR; TGFB1; MITF; IL1A; RELB; FCGR2B
Hippo signaling pathway
AXIN1; GDF5; PPP2R2C; DLG3; SMAD2; SNAI2; PPP2R1B; FZD6; BBC3; AXIN2
Adherens junction
PVRL2; PTPN1; INSRA; TGFBR1; RAC1; RAC1A; TGFBR1A; NLK2; CTNNB1; MLLT4
Chagas disease (American trypanosomiasis)
NFKBIA; ACE; PIK3R1; CCL2; C1QB; IL1B; CD247; CCL3L3; C1QA; IFNGR1
HTLV-I infection
WNT5A; HLA-DPB1; WNT6; TCF3; PIK3CA; IL1R1; AKT2; HLA-DPA1; PIK3CB; RB1
Pathways in cancer
FAS; PTCH1; PLCB3; BMP2; HSP90AA1; FGF18; PLCG1; MAP2K2; Kitl; IGF1
Transcriptional misregulation in cancer
H3F3B; HIST1H3D; SSX2; HIST2H3A; MEIS1; WNT16; TGFBR2; DEFA3; CLSTN2; ASPSCR1
Colorectal cancer
MAPK1; BAX; PIK3CB; RAC1; APC; RAC2; PIK3CD; TGFB2; APC2; CCND1
Pancreatic cancer
RB1; TGFB1; BRAF; KRAS; RALBP1; ARAF; PIK3CB; RALGDS; RAC1; SMAD4
Chronic myeloid leukemia
CTBP1; PIK3CG; NRAS; ABL1; GAB2; BCR; TGFBR2; CRK; MDM2; PIK3CD

Protein Function

TGFBR2 has several biochemical functions, for example, ATP binding, SMAD binding, glycosaminoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR2 itself. We selected most functions TGFBR2 had, and list some proteins which have the same functions with TGFBR2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ULK3; PSMC1A; ORC5; MYO3A; PSMC2; MOS; P2RY1; HSP90AA1.1; UBE1Y1; ABCF2A
Function SMAD binding
Related Protein COL1A2; PML; TGFBR2; SKOR1B; ACVR1; FKBP1A; SMAD2; ACVR1B; TOB1; MAGI2
Function glycosaminoglycan binding
Related Protein DCN; SPOCK2; BGN; HABP2; Shh; NDNF; SERPINE2; SERPINA5; CCDC80; TGFBR2
Function metal ion binding
Related Protein EIF2S2; EBF4; HBBE2; SDHC; ZNF80; ARHGEF1A; NRAP; ITGA2; KAT8; ZNF317
Function protein binding
Related Protein TNFRSF10A; COA5; ACYP2; RPL27A; LRRK1; FAM9A; ENO1; USP49; DNAJC27; APPL1
Function receptor signaling protein serine/threonine kinase activity
Related Protein BMPR2; SBK3; BMPR1BA; AMHR2; BMPR1BB; BMPR1A; TGFBR1B; ACVR2B; ACVR1C; STK25B
Function transforming growth factor beta binding
Related Protein TGFB3; LTBP4; ITGAV; THBS1; ACVRL1; CD109; TGFBR1; ENG; TGFBR2; LTBP1
Function contributes_to transforming growth factor beta binding
Related Protein TGFBR2; ENG; TGFBR1; TGFBR3
Function transforming growth factor beta receptor activity, type II
Related Protein AMHR2; TGFBR2
Function transforming growth factor beta-activated receptor activity
Related Protein BMPR2B; BMPR2A; ACVRL1; TGFBR1; TGFBR3; ENG; TGFBR2; LTBP1
Function transmembrane receptor protein serine/threonine kinase activity
Related Protein BMPR1B; BMPR1AA; ACVR2AA; BMPR2B; ACVRL1; TGFBR1B; ACVR1BA; BMPR1BB; BMPR1A; ACVR1B
Function type I transforming growth factor beta receptor binding
Related Protein ENG; SNX25; TGFBR2; TGFB3; FKBP1A; SMAD7; TGFB1; SMAD2; SMAD6
Function type III transforming growth factor beta receptor binding
Related Protein TGFB3; TGFBR2; TGFB2; TGFB1

Interacting Protein

TGFBR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR2.
TGFB1; TGFB3; SCUBE3

TGFBR2 Related Gene Family

TGF