ttr
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  • Official Full Name
  • transthyretin
  • Background
  • This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]
  • Synonyms
  • TTR; transthyretin; CTS; CTS1; PALB; TBPA; HEL111; HsT2651; ATTR; carpal tunnel syndrome 1; thyroxine-binding prealbumin; epididymis luminal protein 111; prealbumin, amyloidosis type I;
Cat.#:TTR-561MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TTR Protein, His-tagged
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Cat.#:TTR-2922HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TTR Protein, MYC/DDK-tagged
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Cat.#:Ttr-1392MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ttr Protein
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Cat.#:TTR-11HTag:
Source (Host):Trichoplusia ni larval expression systemSpecies:Human
Product nameRecombinant Human TTR
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Cat.#:TTR-1837HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Transthyretin
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Cat.#:TTR-291HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TTR Protein, His-tagged
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Cat.#:TTR-30616THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TTR
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Cat.#:TTR-31110THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TTR
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Cat.#:TTR-31111THTag:
Source (Host):Species:Human
Product nameRecombinant Human TTR
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Cat.#:TTR-3950HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TTR, His tagged
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Cat.#:TTR-728HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TTR protein, His-tagged
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Cat.#:TTR-17603MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TTR Protein
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Cat.#:Ttr-729MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ttr protein, His-tagged
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Cat.#:TTR-6352RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TTR Protein
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Cat.#:Ttr-731RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ttr protein, His-tagged
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Cat.#:TTR-1059CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TTR Protein, His-tagged
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Cat.#:TTR-5023RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TTR Protein, His-tagged
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Cat.#:TTR-725DTag:His/T7
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog TTR protein, His & T7-tagged
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Cat.#:TTR-5421CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TTR
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Cat.#:TTR-726CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken TTR protein, His-tagged
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Cat.#:TTR-732RTag:His/T7
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit TTR protein, His & T7-tagged
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Cat.#:TTR-1438ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TTR
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Cat.#:TTR-724CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle TTR protein, His-tagged
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Cat.#:Ttr-727GTag:His/T7
Source (Host):E. coliSpecies:Guinea pig
Product nameRecombinant Guinea pig Ttr protein, His & T7-tagged
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Cat.#:TTR-730PTag:His/T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig TTR protein, His & T7-tagged
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Cat.#:TTR-131HTag:
Source (Host):Species:Human
Product nameNative Human Prealbumin protein
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Cat.#:TTR-254HTag:
Source (Host):Species:Human
Product nameNative Human Prealbumin
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Cat.#:TTR-31108THTag:
Source (Host):Species:Human
Product nameNative Human TTR
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Cat.#:TTR-706HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNative Human Transthyretin
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Cat.#:TTR-155BTag:
Source (Host):Species:Bovine
Product nameNative Bovine Prealbumin protein
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Cat.#:TTR-141STag:
Source (Host):Species:Sheep
Product nameNative Sheep prealbumin
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Cat.#:TTR-2149HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TTR cell lysate
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Cat.#:TTR-21HTag:
Source (Host):Species:Human
Product nameHuman Prealbumin Reference Standard
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Cat.#:Ttr-54MTag:N/A
Source (Host):Species:Mouse
Product nameMouse Prealbumin Reference Standard
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Cat.#:Ttr-88RTag:N/A
Source (Host):Species:Rat
Product nameRat Prealbumin Reference Standard
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Involved Pathway

TTR involved in several pathways and played different roles in them. We selected most pathways TTR participated on our site, such as Amyloid formation, Disease, Diseases associated with visual transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TTR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amyloid formation
CEACAM21; NAT8; HIST2H3C; HIST4H4; RHBDL1; TGFBI; SEMG1; MFGE8; CST3; CALCA
Disease
DPF1; CTDP1; OPN1LW; GPC6; RLBP1; AP1M2; STRA6; COBRA1; KREMEN1; MMADHC
Diseases associated with visual transduction
RBP1; OPN1LW; OPN1MW; STRA6; RBP4; RLBP1; OPN1MW2; TTR; OPN1SW
Diseases of signal transduction
OPN1SW; HDAC5; OS9; TNKS2; KREMEN2; FKBP1A; CUX1; CCNC; FGFR1OP; OPN1LW
Extracellular matrix organization
MATN1; COL25A1; TLL1; ELANE; ADAMTS1; ABHD1; EFEMP2; FBLN1; MFAP3; MGC174155
FOXA2 and FOXA3 transcription factor networks
KCNJ11; CPT1B; FOXF1; CPT1C; DLK1; CEBPA; UCP2; CPT1A; TTR; FOXA1
Metabolism of proteins
PHC3; TFG; ARSK; IGFBP6A; B3GNT3; ALG2; IGFALS; TIMM22; IGFBP2A; IGFBP6
Non-integrin membrane-ECM interactions
DDR1; TRAPPC4; LAMC3; TTR; DMD; DDR2

Protein Function

TTR has several biochemical functions, for example, hormone activity, hormone binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TTR itself. We selected most functions TTR had, and list some proteins which have the same functions with TTR. You can find most of the proteins on our site.
Function
Related Protein
Function hormone activity
Related Protein PRL8A9; FAM132A; IGF1; PRL2A1; AMH; TTR; SST6; STC2A; VIP; ADM2A
Function hormone binding
Related Protein LRP2; GPR30; UCN2; MC1R; ADIPOR1A; AMHR2; ADIPOR2; CALR; MTNR1A; NPR1
Function identical protein binding
Related Protein LCP1; SRPX2; LECT2; PPP1R13L; DPY30; CEP72; CXADR; DYRK1A; PNMA5; ACADM
Function protein binding
Related Protein PIP5K1B; AP2S1; ACSF2; GH1; BCS1L; CADPS; CPNE3; TMIGD2; GHRL; SEPT1
Function protein heterodimerization activity
Related Protein SNX5; UGT1A6B; ADRA2C; GTF2A2; VOX; LIFR; TCF3; KCNIP1; IKZF4; BOKA

Interacting Protein

TTR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TTR here. Most of them are supplied by our site. Hope this information will be useful for your research of TTR.
MT3; NECAB2; CDR2; AGER; IKBKAP; VIM

TTR Related Articles

Haussecker, D; et al. Current issues of RNAi therapeutics delivery and development. JOURNAL OF CONTROLLED RELEASE 195:49-54(2014).
Obici, L; Merlini, G; et al. An overview of drugs currently under investigation for the treatment of transthyretin-related hereditary amyloidosis. EXPERT OPINION ON INVESTIGATIONAL DRUGS 23:1239-1251(2014).