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TTR

  • Official Full Name

    transthyretin

  • Overview

    This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]
  • Synonyms

    TTR; transthyretin; CTS; CTS1; PALB; TBPA; HEL111; HsT2651; ATTR; carpal tunnel syndrome 1; thyroxine-binding prealbumin; epididymis luminal protein 111; prealbumin, amyloidosis type I;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Transfected Stable Cell Lines
  • Bovine
  • Cattle
  • Chicken
  • Cynomolgus
  • Cynomolgus monkey
  • Cynomolgus Monkey
  • Dog
  • Guinea pig
  • Human
  • Macaca Fascicularis
  • Mouse
  • Pig
  • Pongo pygmaeus abelii
  • Rabbit
  • Rat
  • Rhesus monkey
  • Sheep
  • Zebrafish
  • Bovine Serum
  • E.coli
  • HEK293
  • HEK293T
  • Human Amniotic
  • Human Cell
  • Human plasma
  • Human Plasma
  • Mammalian Cell
  • Mammalian cells
  • Sheep Serum
  • Trichoplusia Ni Larval
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|T7
  • SUMO
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TTR-30616TH Recombinant Human TTR E.coli N/A
Human TTR-291H Recombinant Human TTR Protein, His-tagged E.coli His
Human TTR-1837H Recombinant Human Transthyretin E.coli N/A
Human TTR-31110TH Recombinant Human TTR E.coli N/A
Human TTR-3950H Recombinant Human TTR protein, His-tagged HEK293 His Gly21-Glu147
Human TTR-31111TH Recombinant Human TTR N/A
Human TTR-11H Recombinant Human TTR Trichoplusia Ni Larval N/A
Human TTR-728H Recombinant Human TTR protein, His-tagged E.coli His Gly21~Glu147
Human TTR-2149HCL Recombinant Human TTR cell lysate Human Cell N/A
Human TTR-254H Native Human Prealbumin Human Plasma N/A
Human TTR-2774H Recombinant Human TTR Protein, His-tagged E.coli N-His Met1-Val105
Human TTR-3880H Recombinant Human TTR protein, His-tagged HEK293 His Gly21-Glu147
Human TTR-131H Native Human Prealbumin protein Human Amniotic N/A Full length native Human Prealbumin
Human TTR-31108TH Native Human TTR Human plasma N/A
Human TTR-1220HFL Recombinant Full Length Human TTR Protein, C-Flag-tagged Mammalian cells Flag
Human TTR-6215H Recombinant Human TTR Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TTR-706H Native Human Transthyretin Human Plasma N/A
Human TTR-128H Recombinant Human TTR Protein, His-tagged E.coli His
Human TTR-2922H Recombinant Human TTR Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TTR-072H Recombinant Human TTR Protein HEK293 147
Human TTR-2273H Recombinant Human TTR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TTR-2273H-B Recombinant Human TTR Protein Pre-coupled Magnetic Beads HEK293
Human TTR-1284H Recombinant Human TTR protein, His-tagged HEK293 His Gly 21 - Glu 147
Human TTR-21H Human Prealbumin Reference Standard N/A
Human TTR-04H Recombinant Human TTR (L55P) Protein (Full Length) E.coli Full Length
Human TTR-129H Recombinant Human TTR Protein, His-tagged E.coli His
Mouse Ttr-729M Recombinant Mouse Ttr protein, His-tagged E.coli His Gly21~Asn147
Mouse TTR-17603M Recombinant Mouse TTR Protein Mammalian Cell His
Mouse Ttr-1392M Recombinant Mouse Ttr Protein E.coli N/A
Mouse TTR-9747M-B Recombinant Mouse TTR Protein Pre-coupled Magnetic Beads HEK293
Mouse TTR-561M Recombinant Mouse TTR protein, His-tagged HEK293 His Met1-Asn147
Mouse Ttr-54M Mouse Prealbumin Reference Standard N/A
Mouse Ttr-3631M Recombinant Mouse Ttr protein, His-SUMO-tagged E.coli His-SUMO 23-147aa
Mouse Ttr-6725M Recombinant Mouse Ttr Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TTR-9747M Recombinant Mouse TTR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ttr-3630M Recombinant Mouse Ttr protein, His-SUMO-tagged E.coli His-SUMO 21-147aa
Mouse Ttr-1240M Recombinant Mouse Ttr protein, His-tagged Yeast His 23-147aa
Mouse Ttr-3632M Recombinant Mouse Ttr protein, GST-tagged E.coli GST 23-147aa
Mouse Ttr-5542M Recombinant Mouse Ttr protein, His-tagged Yeast His 21-147aa
Rat TTR-6352R Recombinant Rat TTR Protein Mammalian Cell His
Rat Ttr-731R Recombinant Rat Ttr protein, His-tagged E.coli His Ala20~Asn147
Rat TTR-6008R-B Recombinant Rat TTR Protein Pre-coupled Magnetic Beads HEK293
Rat TTR-6008R Recombinant Rat TTR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Ttr-88R Rat Prealbumin Reference Standard N/A
Rhesus monkey TTR-5023R Recombinant Rhesus monkey TTR protein, His-Myc-tagged HEK293 His/Myc 21-147aa
Rabbit TTR-732R Recombinant Rabbit TTR protein, His & T7-tagged E.coli His/T7 Pro22~Glu147 (Accession # P07489)
Dog TTR-725D Recombinant Dog TTR protein, His & T7-tagged E.coli His/T7 Ala23~Glu147 (Accession # E2R5U8)
Bovine TTR-155B Native Bovine Prealbumin protein Bovine Serum N/A Full length native Bovine Prealbumin protein
Cattle TTR-724C Recombinant Cattle TTR protein, His-tagged E.coli His Ser22~Ala147 (Accession # O46375)
Cynomolgus TTR-1059C Recombinant Cynomolgus TTR Protein, His-tagged HEK293 His
Cynomolgus monkey TTR-3633C Recombinant Cynomolgus monkey TTR protein, His-tagged E.coli His 21-147aa
Cynomolgus monkey TTR-5077C Recombinant Cynomolgus monkey TTR protein, His-tagged HEK293 His 21-147aa
Cynomolgus Monkey TTR-802C Recombinant Cynomolgus Monkey TTR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey TTR-802C-B Recombinant Cynomolgus Monkey TTR Protein Pre-coupled Magnetic Beads HEK293
Guinea pig Ttr-727G Recombinant Guinea pig Ttr protein, His & T7-tagged E.coli His/T7 Met12~Ala126 (Accession# H0VMD5)
Macaca Fascicularis TTR-01H Recombinant Cynomolgus TTR Protein, His-tagged HEK293 His 133
Pongo pygmaeus abelii TTR-3771P Recombinant Pongo pygmaeus abelii TTR protein, His-SUMO-tagged E.coli His-SUMO 21-147aa
Sheep TTR-141S Native Sheep prealbumin Sheep Serum N/A Full length native Sheep prealbumin
Zebrafish TTR-1438Z Recombinant Zebrafish TTR Mammalian Cell His
Zebrafish TTR-3667Z Recombinant Zebrafish TTR protein, His-tagged E.coli His 20-149aa
Pig TTR-730P Recombinant Pig TTR protein, His & T7-tagged E.coli His/T7 Gly21~Leu150 (Accession # P50390)
Chicken TTR-726C Recombinant Chicken TTR protein, His-tagged E.coli His Ala21~Glu150 (Accession # P27731)
Chicken TTR-5421C Recombinant Chicken TTR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TTR Related Articles
  • TTR Related Research Area

TTR involved in several pathways and played different roles in them. We selected most pathways TTR participated on our site, such as Amyloid formation, Disease, Diseases associated with visual transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TTR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amyloid formationCEACAM21;HIST4H4;ODAM;CALCA;LTF;TGFBI;MFGE8;SAA1;RHBDL1
DiseaseANTXR2;FMOD;SFTPB;RNF43;AP2B1;DOCK2;HDAC5;gag;TNKS
Diseases associated with visual transductionRBP4;STRA6;OPN1MW;TTR;RBP1;OPN1LW;RLBP1;OPN1MW2;OPN1SW
Diseases of signal transductionCCNC;MYO18A;RNF43;OPN1SW;TNKS2;OS9;RBP4;STRA6;CDC37
Extracellular matrix organizationLTBP2;TPSAB1;MFAP5;DDR2;CEACAM6;TLL2;COL6A1;NID1;COL10A1A
FOXA2 and FOXA3 transcription factor networksTTR;CPT1C;DLK1;FOXF1;UCP2;CPT1A;CPT1B;KCNJ11;FOXA1
Metabolism of proteinsCTSH;ALG2;B3GNT6;YY2;EID3;TIMM8A;TOMM40;CHCHD4;PIGK
Non-integrin membrane-ECM interactionsTTR;DDR1;DMD;LAMC3;TRAPPC4;DDR2

TTR has several biochemical functions, for example, hormone activity, hormone binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TTR itself. We selected most functions TTR had, and list some proteins which have the same functions with TTR. You can find most of the proteins on our site.

Function Related Protein
hormone activityGIP;PRL2C3;SST6;GALP;PTH1A;PRL2;LEP;PRLH;PTHLH
hormone bindingMC5R;UCN2;TTR;CRYM;NPR3;MTNR1A;GPR30;ADIPOR2;NPR2
identical protein bindingEWSR1;SHMT2;PFKL;GOT2;BNIPL;GRIN3A;SMAD1;EPS15;SELK
protein bindingPAGE2;NR5A2;INSIG2;SERPING1;IL32;SREBF2;MTF1;ATP6V0A2;PCID2
protein heterodimerization activityPOLE3;DMRT3;TAF9;H2-AA;TAF12;TPD52;APITD1;STX1A;DMRT1

TTR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TTR here. Most of them are supplied by our site. Hope this information will be useful for your research of TTR.

MT3; NECAB2; CDR2; AGER; IKBKAP; VIM

Haussecker, D; et al. Current issues of RNAi therapeutics delivery and development. JOURNAL OF CONTROLLED RELEASE 195:49-54(2014).
Obici, L; Merlini, G; et al. An overview of drugs currently under investigation for the treatment of transthyretin-related hereditary amyloidosis. EXPERT OPINION ON INVESTIGATIONAL DRUGS 23:1239-1251(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
What are the main physiologic functions of TTR? 07/14/2022

TTR is involved in the transport of thyroxine and retinol and plays a role in processes such as protein degradation.

How are RAGE proteins related to TTR proteins? 11/23/2021

RAGE proteins interact with TTR proteins and are involved in the regulation of TRR expression.

In which animals is TTR expressed? 06/07/2021

TTR proteins are highly conserved and are found in several vertebrates, such as humans, rats, sheep, and chickens.

Where is TTR primarily synthesized? 03/05/2021

TTR is mainly synthesized in the liver.

TTR is closely linked to research on what diseases 10/22/2020

TTR is associated with a variety of diseases including amyloidosis TTR (ATTR), dementia (AD) and neurological damage.

Customer Reviews (3)

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Reviews
07/14/2022

    Timely delivery, so I got the desired experimental results in the shortest possible time.

    11/26/2021

      I have a dedicated staff member who contacts me and keeps me informed on the progress of custom protein production.

      01/02/2021

        The purchased product information is in line with the advertising campaign and is conducive to obtaining accurate experimental results.

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