CD63

  • Official Full Name

    CD63 molecule

  • Overview

    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
  • Synonyms

    CD63; CD63 molecule; MLA1; ME491; LAMP-3; OMA81H; TSPAN30; CD63 antigen; tspan-30; granulophysin; tetraspanin-30; melanoma-associated antigen MLA1; CD63 antigen (melanoma 1 antigen); melanoma-associated antigen ME491; ocular melanoma-associated antigen; lysosomal-associated membrane protein 3; lysosome-associated membrane glycoprotein 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Cynomolgus
  • Cynomolgus Monkey
  • Felis catus (Cat) (Felis silvestris catus)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Pig
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • DYKDDDDK
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|SUMOstar
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD63-192H Active Recombinant Human CD63 Full Length Transmembrane protein(MNP) HEK293 N/A
Human CD63-2946H Active Recombinant Human CD63 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human CD63-3890H Recombinant Human CD63 protein, His-tagged HEK293 His Ala103-Val203
Human CD63-6837H Recombinant Human CD63 protein, His & GST-tagged E.coli His/GST Ala103~Val203 (Accession # P08962)
Human CD63-0840H Recombinant Human CD63 Protein Wheat Germ N/A
Human CD63-1913HCL Recombinant Human CD63 cell lysate Human Cell N/A
Human CD63-2668H Recombinant Human CD63 protein, His-tagged E.coli His 103-203aa
Human CD63-3584H Recombinant Human CD63 protein, His-tagged E.coli His 104-209 aa
Human CD63-151H Recombinant Human CD63 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CD63-180HFL Recombinant Full Length Human CD63 Protein, C-Flag-tagged Mammalian cells Flag
Human CD63-3112H Recombinant Human CD63 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD63-5371H Recombinant Human CD63 protein, His-tagged Yeast His 103-203aa
Human CD63-544H Recombinant Human CD63 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD63-1382H Recombinant Human CD63 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD63-2512H Recombinant Human CD63 Protein (103-203 aa), His-sumostar-tagged Yeast His/SUMOstar 103-203 aa
Human CD63-3017HF Recombinant Full Length Human CD63 Protein In Vitro Cell Free System 372 amino acids
Human CD63-544H-B Recombinant Human CD63 Protein Pre-coupled Magnetic Beads HEK293
Human CD63-203H Recombinant Human CD63 Protein, C-His-tagged E.coli C-His
Human CD63-1324H Recombinant Human CD63 Protein (Ala103-Val203), N-GST tagged E.coli N-GST Ala103-Val203
Human CD63-1286H Recombinant Human CD63 Protein (Ala103-Val203), C-His tagged Mammalian cells C-His Ala103-Val203
Human CD63-4837H Recombinant Human CD63 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 2-238aa
Mouse Cd63-878M Recombinant Mouse Cd63 Protein, Fc-tagged HEK293 Fc
Mouse CD63-3102M Recombinant Mouse CD63 Protein Mammalian Cell His
Mouse Cd63-879M Recombinant Mouse Cd63 protein(Ala103-Ile203) HEK293 N/A Ala103-Ile203
Mouse CD63-396M Recombinant Mouse CD63 Protein (103-203 aa), GST-tagged E.coli GST 103-203 aa
Mouse Cd63-2669M Recombinant Mouse Cd63 protein, His-tagged E.coli His 103-203aa
Mouse Cd63-845M Recombinant Mouse Cd63 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CD63-1465M Recombinant Mouse CD63 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CD63-1465M-B Recombinant Mouse CD63 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cd63-880M Recombinant Mouse Cd63 protein (Ala103-Ile203) HEK293
Rat Cd63-546R Recombinant Rat Cd63, Fc-tagged Human Cell Fc Ala103-Val203
Rat CD63-1261R Recombinant Rat CD63 protein, His-tagged HEK293 His Ala103-Val203
Rat Cd63-30R Recombinant Rat Cd63, His tagged Human Cell His
Rat CD63-001RCL Recombinant Rat CD63 cell lysate Human Cell N/A
Rat CD63-919R-B Recombinant Rat CD63 Protein Pre-coupled Magnetic Beads HEK293
Rat CD63-919R Recombinant Rat CD63 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL25099BF Recombinant Full Length Bovine Cd63 Antigen(Cd63) Protein, His-Tagged E.coli expression system His Full Length (1-237)
Cynomolgus CD63-101C Recombinant Cynomolgus CD63 protein, His-tagged HEK293 His Ala103-Val203
Cynomolgus Monkey CD63-814CCL Recombinant Cynomolgus CD63 cell lysate Human Cell N/A
Felis catus (Cat) (Felis silvestris catus) RFL8789FF Recombinant Full Length Cat Cd63 Antigen(Cd63) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-238)
Homo sapiens (Human) RFL29403HF Recombinant Full Length Human Cd63 Antigen(Cd63) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-238aa)
Mus musculus (Mouse) RFL10469MF Recombinant Full Length Mouse Cd63 Antigen(Cd63) Protein, His-Tagged E.coli expression system His Full Length (1-238)
Oryctolagus cuniculus (Rabbit) RFL3211OF Recombinant Full Length Rabbit Cd63 Antigen(Cd63) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-238)
Rattus norvegicus (Rat) RFL36047RF Recombinant Full Length Rat Cd63 Antigen(Cd63) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-238)
Rhesus Macaque CD63-747R Recombinant Rhesus monkey CD63 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CD63-573R-B Recombinant Rhesus Macaque CD63 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CD63-573R Recombinant Rhesus Macaque CD63 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CD63-9948Z Recombinant Zebrafish CD63 Mammalian Cell His
Pig CD63-570P Recombinant Pig CD63 Protein, Fc-tagged HEK293 Fc
Pig CD63-1553SCL Recombinant Sus scrofa (Pig) CD63 cell lysate Human Cell N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CD63 involved in several pathways and played different roles in them. We selected most pathways CD63 participated on our site, such as Lysosome, Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD63 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
LysosomeENTPD4;PSAP;LAMP3;CLN3;LITAF;HEXB;AP3S1;NAPSA;SLC11A1
Proteoglycans in cancerPLCG2;PDCD4;Ctsl;ITGA5;BRAF;PIK3R1;ARHGEF1;GRB2;PLAUR

CD63 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD63 itself. We selected most functions CD63 had, and list some proteins which have the same functions with CD63. You can find most of the proteins on our site.

Function Related Protein
protein bindingFARSA;SPON1;PBX1;ARMC2;CTF1;FMO4;CCS;GNAI2;CREBZF

CD63 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD63 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD63.

env; TIMP1; LMP1; ITGB1; SRC; Ptpra; Enam; Ambn; q6krg0_bacan; Amelx

Research Area

Related articles

Antoine, F; Girard, D; et al. Curcumin increases gelatinase activity in human neutrophils by a p38 mitogen-activated protein kinase (MAPK)-independent mechanism. JOURNAL OF IMMUNOTOXICOLOGY 12:188-193(2015).
Scadding, GW; Eifan, A; et al. Local and systemic effects of cat allergen nasal provocation. CLINICAL AND EXPERIMENTAL ALLERGY 45:613-623(2015).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How is CD63 involved in cancer progression? 08/12/2022

It is associated with cancer progression, impacting cell migration and metastasis.

What role does CD63 play in immune cell function? 01/27/2021

CD63 modulates immune responses, influencing antigen presentation and cell activation.

Are there potential therapeutic applications targeting CD63? 10/03/2020

Targeting CD63 may offer therapeutic potential in cancer and immune-related diseases.

How is CD63 expression regulated in cells? 05/12/2020

Its expression is regulated through transcriptional and post-translational mechanisms.

How does CD63 contribute to vesicular trafficking? 01/02/2019

It helps in the sorting and transport of proteins within endosomes and lysosomes.

What is the relationship between CD63 and exosomes? 08/07/2018

CD63 is a marker for exosomes, playing a role in their formation and function.

What is the primary function of CD63 in cellular processes? 01/18/2018

CD63 is involved in vesicular trafficking, cell adhesion, and signaling.

Customer Reviews (3)

Write a review
Reviews
11/26/2022

    Consistent and reliable protein.

    08/23/2022

      Excellent yield, very pure.

      06/19/2021

        Perfect for specific experiments.

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