Recombinant Full Length Human CD63 Protein, C-Flag-tagged

• Cat.No.: CD63-180HFL
• Product Overview: Recombinant Full Length Human CD63 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 25.5 kDa
• AA Sequence: MAVEGGMKCVKFLLYVLLLAFCACA VGLIAVGVGAQLVLSQTIIQGATPG SLLPVVIIAVGVFLFLVAFV GCCGACKENYCLMITFAIFLSLIML VEVAAAIAGYVFRDKVMSEFNNNFR QQMENYPKNNHTASILDRMQ ADFKCCGAANYTDWEKIPSMSKNRV PDSCCINVTVGCGINFNEKAIHKEG CVEKIGGWLRKNVLVVAAAA
  LGIAFVEVLGIVFACCLVKSIRSGY EVMTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Lysosome

Gene Information

• Gene Name: CD63 CD63 molecule [ Homo sapiens (human) ]
• Official Symbol: CD63
• Synonyms: MLA1; ME491; LAMP-3; OMA81H; TSPAN30
• Gene ID: 967
• mRNA Refseq: NM_001780.6
• Protein Refseq: NP_001771.1
• MIM: 155740
• UniProt ID: P08962

Reviews

11/26/2022

Consistent and reliable protein.

08/23/2022

Excellent yield, very pure.

06/19/2021

Perfect for specific experiments.

Q&As

How is CD63 involved in cancer progression?

It is associated with cancer progression, impacting cell migration and metastasis.

What role does CD63 play in immune cell function?

CD63 modulates immune responses, influencing antigen presentation and cell activation.

Are there potential therapeutic applications targeting CD63?

Targeting CD63 may offer therapeutic potential in cancer and immune-related diseases.

How is CD63 expression regulated in cells?

Its expression is regulated through transcriptional and post-translational mechanisms.

How does CD63 contribute to vesicular trafficking?

It helps in the sorting and transport of proteins within endosomes and lysosomes.

What is the relationship between CD63 and exosomes?

CD63 is a marker for exosomes, playing a role in their formation and function.

What is the primary function of CD63 in cellular processes?

CD63 is involved in vesicular trafficking, cell adhesion, and signaling.