Recombinant Human CD63 protein, His & GST-tagged

• Cat.No.: CD63-6837H
• Product Overview: Recombinant Human CD63 aa. (Ala103~Val203 (Accession # P08962)) fused with N-terminal His & GST tag was produced in E. coli cells.

Specification

• Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.
• Source: E. coli
• Species: Human
• Tag: His&GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 43.9kDa.
• Protein length: Ala103~Val203 (Accession # P08962)
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 6.9.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: CD63 CD63 molecule [ Homo sapiens (human) ]
• Official Symbol: CD63
• Synonyms: MLA1; ME491; LAMP-3; OMA81H; TSPAN30; CD63 antigen (melanoma 1 antigen); granulophysin; lysosomal-associated membrane protein 3; lysosome-associated membrane glycoprotein 3; melanoma-associated antigen ME491; melanoma-associated antigen MLA1; ocular melanoma-associated antigen; tetraspanin-30; tspan-30; CD63 antigen
• Gene ID: 967
• mRNA Refseq: NM_001257389.1
• Protein Refseq: NP_001244318.1
• UniProt ID: P08962

Reviews

11/26/2022

Consistent and reliable protein.

08/23/2022

Excellent yield, very pure.

06/19/2021

Perfect for specific experiments.

Q&As

How is CD63 involved in cancer progression?

It is associated with cancer progression, impacting cell migration and metastasis.

What role does CD63 play in immune cell function?

CD63 modulates immune responses, influencing antigen presentation and cell activation.

Are there potential therapeutic applications targeting CD63?

Targeting CD63 may offer therapeutic potential in cancer and immune-related diseases.

How is CD63 expression regulated in cells?

Its expression is regulated through transcriptional and post-translational mechanisms.

How does CD63 contribute to vesicular trafficking?

It helps in the sorting and transport of proteins within endosomes and lysosomes.

What is the relationship between CD63 and exosomes?

CD63 is a marker for exosomes, playing a role in their formation and function.

What is the primary function of CD63 in cellular processes?

CD63 is involved in vesicular trafficking, cell adhesion, and signaling.