Recombinant Human SAA Protein

• Cat.No.: SAA1-1052H
• Product Overview: Recombinant Human serum amyloid A (SAA) protein with an N-terminal histidine tag. Predicted molecular weight: 14 kD.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: Serum amyloid A, a family of apolipoproteins, is associated with high density lipoprotein during inflammatory states. The level of serum amyloid A (SAA) in the blood increases dramatically in response to tissue injury and inflammation. SAA also acts as a cytokine, influencing cell adhesion, migration, proliferation and aggregation. SAAs are implicated in several chronic inflammatory diseases, such as amyloidosis, atherosclerosis, and rheumatoid arthritis.
• Molecular Mass: 14 kDa
• Purity: N/A
• Storage: 2-8 centigrade
• Concentration: 0.5 mg/ml when reconstituted with 200 µl of deionized water
• Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.02 % Tween 20; 6 % sucrose as stabilizer

Gene Information

• Gene Name: SAA1 serum amyloid A1 [ Homo sapiens ]
• Official Symbol: SAA1
• Synonyms: SAA1; serum amyloid A1; SAA; serum amyloid A protein; PIG4; TP53I4; tumor protein p53 inducible protein 4; SAA2; MGC111216
• Gene ID: 6288
• mRNA Refseq: NM_000331
• Protein Refseq: NP_000322
• MIM: 104750
• UniProt ID: P02735

Reviews

06/05/2022

Gel electrophoresis consistently displayed well-defined bands, affirming the product's purity and reliability.

09/21/2018

The product's manufacturer went above and beyond to ensure our satisfaction, strengthening our trust in the brand.

09/15/2018

The value derived from the product's usage made the investment worthwhile, considering the insights acquired.

Q&As

Are there specific stimuli or triggers that induce the expression and secretion of SAA1, influencing its role in the acute-phase response?

Specific stimuli or triggers, such as infection or tissue damage, induce the expression and secretion of SAA1, influencing its role in the acute-phase response.

What diseases or conditions are associated with dysregulation or abnormal expression of SAA1, especially in the context of inflammatory disorders?

Dysregulation or abnormal expression of SAA1 is associated with various inflammatory disorders, including rheumatoid arthritis and atherosclerosis.

In which cellular compartments is SAA1 predominantly synthesized and secreted?

SAA1 is predominantly synthesized in the liver and secreted into the bloodstream, serving as a major acute-phase protein.

What is the primary role of Serum Amyloid A1 (SAA1) in cellular processes and acute-phase responses?

Serum Amyloid A1 (SAA1) plays a crucial role in cellular processes, primarily contributing to acute-phase responses and inflammatory reactions.

How does SAA1 contribute to inflammation, particularly in the context of acute-phase reactions?

SAA1 contributes to inflammation by actively participating in acute-phase reactions, amplifying the immune response during various challenges.

Are there therapeutic implications or potential targets related to SAA1 in diseases involving acute-phase responses and chronic inflammation?

There are potential therapeutic implications related to SAA1 in diseases involving acute-phase responses and chronic inflammation, making it a target for drug development.

How does SAA1 participate in modulating immune responses and influencing the progression of inflammatory conditions?

SAA1 actively modulates immune responses, influencing the progression of inflammatory conditions and contributing to tissue repair.