Active Recombinant Human BIRC7 Protein, GST-tagged, Active BIRC7-636H

Active Recombinant Human BIRC7 Protein, GST-tagged, Active


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Cat.No. : BIRC7-636H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human BIRC7 fused with GST tag at N-terminal was expressed in Insect cells.
Description : Baculoviral IAP repeat-containing protein 7 (BIRC7) is a member of the newly discovered inhibitor of apoptosis proteins (IAPs) family whose activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase. Highly expressed in tumor tissues and inhibits tumor cell apoptosis through blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. BIRC7 expression in breast cancer correlated with the clinical stage and axillary lymph node metastasis, and promotes breast cancer metastasis through the activation of AKT signaling and induction of EMT in breast cancer cells.
Source : Insect cells
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol
Bio-activity : 30 nmol/min/mg
Molecular Mass : 60 kDa
Purity : >95%
Applications : Ubiquitin Enzyme Assay, Western Blot
Stability : 1 year at - 70 centigrade from the date of shipment.
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 ug/ml
Figure :

Gene Name : BIRC7 baculoviral IAP repeat containing 7 [ Homo sapiens ]
Official Symbol : BIRC7
Synonyms : BIRC7; baculoviral IAP repeat containing 7; baculoviral IAP repeat-containing protein 7; KIAP; kidney inhibitor of apoptosis protein; livin; livin inhibitor of apoptosis; melanoma inhibitor of apoptosis protein; ML IAP; mliap; RNF50; RING finger protein 50; LIVIN; MLIAP; ML-IAP;
Gene ID : 79444
mRNA Refseq : NM_022161
Protein Refseq : NP_071444
MIM : 605737
UniProt ID : Q96CA5
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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