Active Recombinant Human Chemokine (C-C Motif) Ligand 21, MIgG2a Fc-tagged

• Cat.No.: CCL21-122H
• Product Overview: The extracellular domain of human CCL21 (AAH27918.1)(Ser24-Pro134) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell.

Specification

• Description: This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19)
• Source: CHO cell
• Species: Human
• Tag: MIgG2a Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to chemoattract 5-10 day cultured human peripheral blood lymphocytes (PBL).
• Molecular Mass: 38KDa (monomer)
• AA Sequence: Ser24-Pro134
• Endotoxin: <0.06 eu/μg as determined by lal>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.
• Protein length: Ser24-Pro134

Gene Information

• Gene Name: CCL21 chemokine (C-C motif) ligand 21 [ Homo sapiens ]
• Official Symbol: CCL21
• Synonyms: CCL21; chemokine (C-C motif) ligand 21; SCYA21, small inducible cytokine subfamily A (Cys Cys), member 21; C-C motif chemokine 21; 6Ckine; beta chemokine exodus 2; CKb9; ECL; Efficient Chemoattractant for Lymphocytes; exodus 2; secondary lymphoid tissue chemokine; SLC; TCA4; exodus-2; beta chemokine exodus-2; beta-chemokine exodus-2; small-inducible cytokine A21; secondary lymphoid-tissue chemokine; small inducible cytokine subfamily A (Cys-Cys), member 21; SCYA21; MGC34555
• Gene ID: 6366
• mRNA Refseq: NM_002989
• Protein Refseq: NP_002980
• MIM: 602737
• UniProt ID: O00585
• Chromosome Location: 9p13
• Pathway: Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem
• Function: CCR7 chemokine receptor binding; chemokine activity; chemokine activity

Reviews

11/21/2022

CCL21 products are reliable and stable, and are widely used in scientific research, industrial production and medical fields.

04/10/2022

CCL21 has a long half-life and can maintain stability and reliability during the experiment.

06/28/2021

When using CCL21 protein for experiments, it can meet specific experimental requirements and research purposes.

Q&As

Does CCL21 have relationships with other genes or proteins?

This has a complex relationship with other genes or proteins, and can interact with other genes or proteins to participate in a variety of biochemical reactions.

What are the applications of CCL21 in medical treatment?

It can be used as a biomarker in medical treatment to help monitor disease progression and treatment efficacy. In addition, therapeutics targeting CCL21, such as targeted therapies or modulating its expression, are also being investigated.

What diseases can CCL21 deficiency or aberrant expression cause?

CCL21 deficiency or aberrant expression may be associated with some autoimmune diseases, cancer, and neurodegenerative diseases.

Might abnormal CCL21 levels be indicative of disease?

Abnormal levels of CCL21 may suggest autoimmune diseases, cancer, and neurodegenerative diseases, but they may also be associated with other diseases.

How to study the regulatory mechanism of CCL21?

Studying the regulatory mechanism of CCL21 requires a combination of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

How are mutations in CCL21 detected and analyzed?

Mutations in CCL21 can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.