Recombinant Human CCL21, GST-tagged
| Cat.No. : | CCL21-10843H |
| Product Overview : | Recombinant Human CCL21 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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| Description : | This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. |
| Source : | E.coli |
| Species : | Human |
| Tag : | GST |
| Protein length : | C-term-115a.a. |
| Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
| Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
| Gene Name : | CCL21 chemokine (C-C motif) ligand 21 [ Homo sapiens ] |
| Official Symbol : | CCL21 |
| Synonyms : | CCL21; chemokine (C-C motif) ligand 21; SCYA21, small inducible cytokine subfamily A (Cys Cys), member 21; C-C motif chemokine 21; 6Ckine; beta chemokine exodus 2; CKb9; ECL; Efficient Chemoattractant for Lymphocytes; exodus 2; secondary lymphoid tissue chemokine; SLC; TCA4; exodus-2; beta chemokine exodus-2; beta-chemokine exodus-2; small-inducible cytokine A21; secondary lymphoid-tissue chemokine; small inducible cytokine subfamily A (Cys-Cys), member 21; SCYA21; MGC34555; |
| Gene ID : | 6366 |
| mRNA Refseq : | NM_002989 |
| Protein Refseq : | NP_002980 |
| MIM : | 602737 |
| UniProt ID : | O00585 |
| Chromosome Location : | 9p13 |
| Pathway : | Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem; |
| Function : | CCR7 chemokine receptor binding; chemokine activity; chemokine activity; |
Products Types
| ◆ Recombinant Protein | ||
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| ◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThis has a complex relationship with other genes or proteins, and can interact with other genes or proteins to participate in a variety of biochemical reactions.
It can be used as a biomarker in medical treatment to help monitor disease progression and treatment efficacy. In addition, therapeutics targeting CCL21, such as targeted therapies or modulating its expression, are also being investigated.
CCL21 deficiency or aberrant expression may be associated with some autoimmune diseases, cancer, and neurodegenerative diseases.
Abnormal levels of CCL21 may suggest autoimmune diseases, cancer, and neurodegenerative diseases, but they may also be associated with other diseases.
Studying the regulatory mechanism of CCL21 requires a combination of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.
Mutations in CCL21 can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.
Customer Reviews (3)
Write a reviewCCL21 products are reliable and stable, and are widely used in scientific research, industrial production and medical fields. -
CCL21 has a long half-life and can maintain stability and reliability during the experiment. -
When using CCL21 protein for experiments, it can meet specific experimental requirements and research purposes. -
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