Active Recombinant Human CXCL11 Protein

• Cat.No.: CXCL11-280H-AF647
• Product Overview: Escherichia coli expressed Human CXCL11 protein was labeled with AF647 in vitro.

Specification

• Description: CXCL11 also known as I-TAC is belonging to the CXC chemokine family and shares 36 % and 37 % amino acid sequence homology with IP-10 and MIG, respectively. It is highly expressed in peripheral blood leukocytes, pancreas and liver. Expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3, which with a higher affinity than do the other chemokines for this receptor, CXCL9 and CXCL10. Similar to CXCL10, CXCL11 has been shown to be a chemoattractant for IL-2-activated T-lymphocytes, but not for isolated T-cells, neutrophils or monocytes.
• Source: E. coli
• Species: Human
• Form: Solution
• Bio-activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human IL-2 activated human T-lymphocytes is in a concentration range of 0.1-10 ng/ml.
• Molecular Mass: Approximately 8.3 kDa, a single non-glycosylated polypeptide chain containing 73 amino acids
• Protein Length: 73 aa
• AA Sequence: FPMFKRGRCL CIGPGVKAVK VADIEKASIM YPSNNCDKIE VIITLKENKG QRCLNPKSKQ ARLIIKKVER KNF
• Endotoxin: Less than 1 EU/µg of rHuI-TAC/CXCL11 as determined by LAL method.
• Purity: >97% by SDS-PAGE and HPLC analysis.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied.
• Concentration: 2.0 mg/mL

Gene Information

• Gene Name: CXCL11 C-X-C motif chemokine ligand 11 [ Homo sapiens (human) ]
• Official Symbol: CXCL11
• Synonyms: IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B
• Gene ID: 6373
• mRNA Refseq: NM_005409.5
• Protein Refseq: NP_005400.1
• MIM: 604852
• UniProt ID: O14625