Active Recombinant Human FLT3LG Protein (Thr27-Ala181), GMP Grade, Animal-Free

Cat.No. : FLT3LG-32HG
Product Overview : GMP recombinant human Flt-3 Ligand/FLT3L protein (Thr27-Ala181) without tag was expressed in E. coli, produced in an Animal-Free laboratory and manufactured and tested under cGMP guidelines.
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Description : Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts.
Source : E. coli
Species : Human
Bio-activity : Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with mouse Flt-3. The ED50 for this effect is 0.2-1 ng/mL.
The specific activity of Recombinant Human Flt-3 Ligand/FLT3L is >5.0 x 105 units/mg, which is calibrated against the human Flt-3 Ligand WHO Standard.
Molecular Mass : Predicted Molecular Mass: 18 kDa
SDS-PAGE: 15-17 kDa, under reducing conditions
Protein Length : Thr27-Ala181
N-terminal Sequence Analysis : Met-Thr27-Gln-Asp-(Cys)-Ser-Phe-Gln-His-Ser and Thr27-Gln-Asp-(Cys)-Ser-Phe-Gln-His-Ser-Pro
Endotoxin : <0.10 EU/ μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
A minimum of 6 months when stored at ≤ -20 centigrade as supplied. Refer to lot specific COA for the Use by Date.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, ≤ -20 centigrade under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution : Reconstitute at 100-500 μg/mL in PBS.
Shipping : The product is shipped with polar packs.
Gene Name : FLT3LG fms-related tyrosine kinase 3 ligand [ Homo sapiens ]
Official Symbol : FLT3LG
Synonyms : FLT3LG; fms-related tyrosine kinase 3 ligand; flt3 ligand; FL; FLT3L;
Gene ID : 2323
mRNA Refseq : NM_001204502
Protein Refseq : NP_001191431
MIM : 600007
UniProt ID : P49771

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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