Active Recombinant Human IL22 Protein
|Product Overview :||Recombinant Human IL22 Protein without tag was expressed in HEK 293.|
- Gene Information
- Related Products
|Description :||Interleukin-22 (IL-22) is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-ß/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.|
|Source :||HEK 293|
|Form :||Sterile Filtered White lyophilized (freeze-dried) powder.|
|Bio-activity :||Active, measured by its ability to activate STAT following receptor ligand interaction.|
|Molecular Mass :||16~28 kDa, observed by reducing SDS-PAGE.|
|AA Sequence :||APISSHCRLDKSNFQQPYITNRTFM LAKEASLADNNTDVRLIGEKLFHGV SMSERCYLMKQVLNFTLEEVLFPQS DRFQPYMQEVVPFLARLSNRLSTCH IEGDDLHIQRNVQKLKDTVKKLGES GEIKAIGELDLLFMSLRNACI|
|Endotoxin :||< 0.2 EU/μg, determined by LAL method.|
|Purity :||> 95% as analyzed by SDS-PAGE.|
|Storage :||Lyophilized recombinant Human Interleukin-22 (IL-22) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, Human Interleukin-22 (IL-22) should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade.|
|Storage Buffer :||Lyophilized after extensive dialysis against PBS.|
|Reconstitution :||Reconstituted in ddH2O or PBS at 100 μg/mL.|
|Gene Name :||IL22 interleukin 22 [ Homo sapiens ]|
|Official Symbol :||IL22|
|Synonyms :||IL22; interleukin 22; interleukin-22; IL 10 related T cell derived inducible factor; IL 21; IL 22; IL D110; IL TIF; ILTIF; MGC79382; MGC79384; TIFa; TIFIL 23; zcyto18; cytokine Zcyto18; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-21; IL-22; IL-TIF; IL-D110; TIFIL-23;|
|Gene ID :||50616|
|mRNA Refseq :||NM_020525|
|Protein Refseq :||NP_065386|
|UniProt ID :||Q9GZX6|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
IL22 enhances gut epithelial repair mechanisms.
IL22 activates STAT3 to modulate downstream targets.
IL22 interacts synergistically with IL-17 during inflammation.
IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.
IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.
IL22 expression is upregulated in psoriasis.
IL22 expression is upregulated during viral infections like Hepatitis C.
IL22 contributes to anti-tumor immunity by activating NK cells.
IL22 promotes Th22 cell differentiation.
IL22 polymorphisms affect its binding affinity and signaling.
Customer Reviews (3)Write a review
High specificity. -
Good for Th17 differentiation. -
Effective in gut repair assays. -
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