Active Recombinant Human IL23A Protein, Animal Free
|Product Overview :
|Recombinant Human IL23A Protein without tag was expressed in Human cells.
Animal Free and Xeno Free
- Gene Information
- Related Products
|IL-23 is a heterodimeric cytokine composed of two subunits: a unique p19 subunit, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T cells and promotes production of proinflammatory cytokines, such as IFNγ and IL-17. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
|The activity was measured by its ability to induce the IL-17 expression in murine splenocytes.
|Molecular Mass :
|<0.5 EU/ μg
|High Purity, >95% by SDS-PAGE
|Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -80 centigrade under sterile conditions after reconstitution.
|Storage Buffer :
|Lyophilized from a 0.2 μm filtered solution in PBS without carrier protein
|Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
|Gene Name :
|IL23A interleukin 23 subunit alpha [ Homo sapiens (human) ]
|Official Symbol :
|IL23A; interleukin 23 subunit alpha; P19; SGRF; IL-23; IL-23A; IL23P19; interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; IL-23p19; JKA3 induced upon T-cell activation; interleukin 23 p19 subunit; interleukin 23, alpha subunit p19; interleukin-23 subunit p19; interleukin-six, G-CSF related factor
|Gene ID :
|mRNA Refseq :
|Protein Refseq :
|UniProt ID :
|◆ Recombinant Protein
|Recombinant Human Il23A&IL12B Protein, His-tagged
|Recombinant Human IL23A Protein, Fc-tagged
|Recombinant Mouse IL23A Protein, His (Fc)-Avi-tagged
|Recombinant Human Il23A Protein, GST-tagged
|Active Recombinant Human IL23A Protein, Myc/DDK-tagged
|Recombinant Human IL23A 293 Cell Lysate
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
Please inquiry our product manager with specific product.
Yes, drugs like ustekinumab and risankizumab, which target IL23A, have been approved for certain autoimmune diseases.
IL23A primarily plays a role in regulating the adaptive immune response.
IL23A is associated with the inflammation of the spine and joints seen in ankylosing spondylitis, making it a target for therapeutic intervention.
In rheumatoid arthritis, IL23A is involved in the dysregulation of the immune system, leading to joint inflammation and damage.
IL23A is implicated in the pathogenesis of Crohn's disease, contributing to chronic inflammation in the gastrointestinal tract.
Customer Reviews (3)Write a review
Coupled with the manufacturer's exceptional technical support and commitment to customer satisfaction, researchers can confidently utilize the IL23A protein in their studies, knowing that they have the necessary resources and assistance to succeed.
Its remarkable attributes and consistent results make it an indispensable tool in various experimental applications.
Highly recommended for its exceptional performance in ELISA, the IL23A protein is a top contender for researchers involved in protein electron microscopy structure analysis.
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