Active Recombinant Mouse Il23a Protein

• Cat.No.: Il23a-3515M
• Product Overview: Purified recombinant protein of Mouse interleukin 23, alpha subunit p19 (Il23a) without tag was expressed in Sf9.

Specification

• Description: Low expression observed in reference dataset
• Source: Sf9
• Species: Mouse
• Bio-activity: The ED50 is 0.5 - 0.8 ng/mL, corresponding to a specific activity of 1.25-2.0 × 10^6 units/mg, determined by mouse splenocytes IL-17A secretion induced by mIL-23 in a dose dependent manner. Under this assay, the bioactivity is equivalent
• Molecular Mass: 55.4 kDa
• Endotoxin: Less than 0.01 ng/μg protein as determined by the LAL method
• Purity: > 95%, as determined by Coomassie stained SDS-PAGE.
• Stability: Unopened vial can be stored between 2 and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: Protein formulated and vialed at >50 μg/mL in specified buffer
• Storage Buffer: 1 x PBS

Gene Information

• Gene Name: Il23a interleukin 23, alpha subunit p19 [ Mus musculus (house mouse) ]
• Official Symbol: Il23a
• Synonyms: Il23a; interleukin 23, alpha subunit p19; p1; IL-; p19; IL-23; interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; IL-23p19; interleukin-23 subunit p19
• Gene ID: 83430
• mRNA Refseq: NM_031252
• Protein Refseq: NP_112542
• UniProt ID: Q9EQ14

Reviews

04/18/2020

Coupled with the manufacturer's exceptional technical support and commitment to customer satisfaction, researchers can confidently utilize the IL23A protein in their studies, knowing that they have the necessary resources and assistance to succeed.

12/02/2016

Its remarkable attributes and consistent results make it an indispensable tool in various experimental applications.

02/25/2016

Highly recommended for its exceptional performance in ELISA, the IL23A protein is a top contender for researchers involved in protein electron microscopy structure analysis.

Q&As

Is this bioactive cyno IL-23 heterodimer (p19/p40) or just the cyno IL-23p19 subunit?

Please inquiry our product manager with specific product.

Are there any FDA-approved drugs targeting IL23A?

Yes, drugs like ustekinumab and risankizumab, which target IL23A, have been approved for certain autoimmune diseases.

Is IL23A involved in the regulation of adaptive or innate immunity?

IL23A primarily plays a role in regulating the adaptive immune response.

How is IL23A linked to the pathogenesis of ankylosing spondylitis?

IL23A is associated with the inflammation of the spine and joints seen in ankylosing spondylitis, making it a target for therapeutic intervention.

How does IL23A contribute to rheumatoid arthritis?

In rheumatoid arthritis, IL23A is involved in the dysregulation of the immune system, leading to joint inflammation and damage.

How is IL23A involved in inflammatory bowel diseases like Crohn's disease?

IL23A is implicated in the pathogenesis of Crohn's disease, contributing to chronic inflammation in the gastrointestinal tract.