Active Recombinant Human IL36A Protein (Lys6-Phe158), C-His tagged, Animal-free, Carrier-free

Cat.No. : IL36A-125H
Product Overview : Recombinant Human IL36A Protein (Lys6-Phe158) with C-His tag was expressed in E. coli and Animal-free as well as Carrier-free.
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Description : Interleukin-36 alpha (IL-36α) is an 18 kDa cytokine with 154 amino acid residues. IL-36α is one of the IL-36 agonists secreted from keratinocytes. When IL-36α binds to the IL-36 receptor, it activates NF-κB and MAPK signaling pathways that induce inflammatory responses. In addition, it also stimulates the production of inflammatory cytokines, such as IFN-γ, TNF-α, and IL-6.
Source : E. coli
Species : Human
Tag : C-His
Form : Lyophilized
Bio-activity : Measure by its ability to induce IL-8 secretion in human PBMCs. The ED50 for this effect is < 0.7 ng/mL.
Molecular Mass : The protein has a calculated MW of 18.05 kDa.
The protein migrates as 17 kDa under reducing condition (SDS-PAGE analysis).
Protein Length : Lys6-Phe158
Endotoxin : < 0.1 EU/μg of the protein by the LAL method.
Purity : >98% as determined by SDS-PAGE analysis.
Storage : This product is stable after storage at:
-20 centigrade for 12 months in lyophilized state from date of receipt.
-20 or -80 centigrade for 1 month under sterile conditions after reconstitution.
Avoid repeated freeze/thaw cycles.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution : It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
Shipping : The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage.
Gene Name : IL36A interleukin 36, alpha [ Homo sapiens (human) ]
Official Symbol : IL36A
Synonyms : IL36A; interleukin 36, alpha; IL1F6, interleukin 1 family, member 6 (epsilon); interleukin-36 alpha; FIL1; FIL1E; IL 1F6; IL1(EPSILON); MGC129552; MGC129553; FIL1 epsilon; IL-1 epsilon; interleukin-1 epsilon; IL-1F6 (FIL-1-epsilon); interleukin 1, epsilon; interleukin-1 family member 6; interleukin 1 family, member 6 (epsilon); IL1F6; IL-1F6; FIL1(EPSILON);
Gene ID : 27179
mRNA Refseq : NM_014440
Protein Refseq : NP_055255
MIM : 605509
UniProt ID : Q9UHA7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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    When conducting experiments with HSP90AA1, clear and reliable interpretation of results can be obtained.


      The IL36A product has low endotoxin levels and does not interfere with experimental results.


        IL36A has important application value in the field of drug research and development, and has achieved certain research results.

        Q&As (6)

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        Does IL36A carry a fever risk? 04/27/2022

        In general, the use of IL36A does not cause significant fever reactions, but individual differences exist, if there are abnormalities, please consult a doctor.

        How to prepare IL36A? 09/07/2021

        The IL36A is expressed, purified, and constructed using recombinant DNA technology in a suitable host expression system, usually through genetic engineering.

        In what inflammatory diseases does recombinant IL36A have potential applications? 05/24/2021

        IL36A has potential application value in psoriasis, arthritis and other inflammatory diseases, but the specific efficacy needs further study.

        Does IL36A have anti-tumor effects? 08/22/2020

        IL36A has been shown in some studies to have anti-proliferative and anti-invasive effects on certain tumors, but more studies are needed to confirm its specific mechanism of action and effect.

        How is the research progress of IL36A? 06/05/2020

        The research of IL36A is progressing continuously, and some studies have shown its potential in immune regulation, anti-inflammatory effect and so on.

        Can IL36A be used in animal experiments? 02/13/2019

        Yes, IL36A can be used in animal studies to investigate its mechanism of action and potential applications.

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