Species : |
Human |
Source : |
CHO |
Tag : |
Fc |
Protein Length : |
1-153 a.a. |
Description : |
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
Form : |
Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : |
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. |
Molecular Mass : |
43 KDa (monomer) |
AA Sequence : |
Met1-Ser153 |
Endotoxin : |
<0.06 eu/μg="" as="" determined="" by="" lal="" test.="">0.06> |
Purity : |
>98%, by SDS-PAGE under reducing conditions. |
Stability : |
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : |
Reconstitute at 100μg/ml in sterile PBS. |
Warning : |
Avoid freeze/thaw cycles. |