Active Recombinant Human IL6 protein(Val30-Met212)
| Cat.No. : | IL6-3395H |
| Product Overview : | Recombinant Human IL6 (NP_000591.1) (Val30-Met212) was expressed in E. coli with an initial Met at the N-terminus. |
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| Source : | E. coli |
| Species : | Human |
| Tag : | Non |
| Protein length : | Val30-Met212 |
| Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
| Bio-activity : | 1. Immobilized Human IL-6 at 2 μg/mL (100 μL/well) can bind Human IL-6R hFc, the EC50 of Human IL-6R hFc is 3.0-10.0 ng/mL. 2. Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.1-0.8 ng/mL. |
| Molecular Mass : | The recombinant human IL6 consists of 184 amino acids and predicts a molecular mass of 20.95 kDa. It migrates as an approximately 19.7 kDa band in SDS-PAGE under reducing conditions. |
| Endotoxin : | < 10 EU per mg of the protein. |
| Purity : | ≥ 95 % as determined by SDS-PAGE |
| Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
| Gene Name : | IL6 interleukin 6 (interferon, beta 2) [ Homo sapiens ] |
| Official Symbol : | IL6 |
| Synonyms : | IL6; interleukin 6 (interferon, beta 2); IFNB2; interleukin-6; BSF2; HGF; HSF; IL 6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation factor; IL-6; |
| Gene ID : | 3569 |
| mRNA Refseq : | NM_000600 |
| Protein Refseq : | NP_000591 |
| MIM : | 147620 |
| UniProt ID : | P05231 |
Products Types
| ◆ Recombinant Protein | ||
| IL6-02H | Active Recombinant Human IL6 Protein (30-212aa), N-His-tagged | +Inquiry |
| IL6-498D | Recombinant Dog IL6 protein, His-tagged | +Inquiry |
| IL6-2003M | Recombinant Mouse IL6 Protein | +Inquiry |
| IL6-001H | Recombinant Human IL6 Protein | +Inquiry |
| Il6-212M | Recombinant Active Mouse IL6 Protein, His-tagged(C-ter) | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewAccurate localization and function within the cell.
The binding affinity and affinity constant with the target are high.
Can form a stable micellar structure.
Q&As (6)
Ask a questionThe dosage and usage of Il6 will vary according to the disease, and generally require individualized regulation by the physician according to the disease situation.
The pharmacokinetic characteristics of Il6 mainly include drug absorption, distribution, metabolism, excretion and other information.
Recombinant Il6 protein has a unique therapeutic advantage in the treatment of multiple myeloma. It can promote the proliferation and differentiation of hematopoietic stem cells and inhibit the growth of tumor cells.
Il6 has specific therapeutic effects for certain diseases, such as rheumatoid arthritis, multiple myeloma and so on.
This protein is widely used in the treatment of rheumatoid arthritis, pneumonia, multiple myeloma, lymphoma, malignant tumors and other diseases.
The effects of Il6 on immune cells are mainly manifested as promoting cell proliferation and differentiation, regulating immune response, etc.
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