Active Recombinant Human Interleukin 17F
Cat.No. : | IL17F-114H |
Product Overview : | Recombinant Human Interleukin 17F encoding the human IL-17F protein sequence (containing the signalpeptide sequence, and the mature IL-17F sequence) was expressed in modifiedhuman 293 cells. |
- Specification
- Gene Information
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Cat. No. : | IL17F-114H |
Description : | Interleukin-17 (IL-17) is a 155 amino acid protein that is a disulfide linked, homodimeric, secreted glycoprotein with one N-linked glycosylation site. IL-17 is also referred to as IL-17A. Other members include IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. IL-17 binds to the cell surfacer receptor IL-17R. IL-17 is secreted by a subset of T cells called T-helper 17 (Th-17) cells. IL-23 is thought to mediate the production of IL-17 by Th-17 cells. |
Source : | Human 293 cells. |
Amino Acid Sequence : | RKIPKVGHTFFQKPESCPPVPGGSM KLDIGIINENQRVSMSRNIESRSTS PWNYTVTWDPNRYPSEVVQAQCRNL GCINAQGKEDISMNSVPIQQETLVV RRKHQGCSVSFQLEKVLVTVGCTCV TPVIHHVQ. |
Molecular Mass : | Under reducing conditions Apollo IL-17F hcx migrates as a broad band between 17 and 21 kDa on SDS-PAGE due to post-translational modifications, in particular glycosylation. This compares with unmodified IL-17F polypeptide that has a predicted monomeric molecular mass of 14.9 kDa. |
pI : | Apollo IL-17F hcx separates into a number of glycoforms with a pI between 6.2 and 9.5 on 2D PAGE due to post-translational modifications, in particular glycosylation. This compares with the unmodified IL-17F that has a predicted pI of 9.04. |
% Carbohydrate : | Apollo purified IL-17F hcx consists of 20-35% carbohydrate by weight. |
Glycosylation : | Apollo IL-17F hcx contains N-linked oligosaccharides. |
Purity : | >95%, as determined by SDS-PAGE, visualised by Coomassie Brilliant Blue. |
Formulation : | When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose. |
Reconstitution : | It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. |
Storage : | Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C and longer-term storage of aliquots at -18 to -20°C is recommended. Repeated freeze thawing is not recommended. |
Activity : | The activity of IL-17F is measured by its ability to induce IL-6 production in NHDF cells. The ED50is typically between 0.04 and 0.1 ng/ml. |
Gene Name : | IL17F interleukin 17F [ Homo sapiens ] |
Synonyms : | IL17F; interleukin 17F; ML1; ML-1; IL-17F; cytokine ML-1;Interleukin-24;leukin-17F |
Gene ID : | 112744 |
mRNA Refseq : | NM_052872 |
Protein Refseq : | NP_443104 |
UniProt ID : | Q96PD4 |
Chromosome Location : | 6p12 |
MIM : | 606496 |
Function : | cytokine activity; cytokine binding; protein homodimerization activity |
Products Types
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◆ Lysates | ||
IL17F-2045HCL | Recombinant Human IL17F cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionTumor xenografts, immune cell infiltration analysis, and therapeutic antibody testing assess IL17F's role in cancer.
Neutrophil chemotaxis assays, in vivo neutrophil tracking, and immune cell activation analysis explore IL17F's impact on neutrophil functions.
Genetic knockout models, functional assays, and gene expression analyses distinguish IL17F's unique roles.
Microbiota composition analysis, germ-free models, and immune cell profiling investigate IL17F-microbiota interactions.
Animal disease models, patient samples, and immunological assays elucidate IL17F's contribution to autoimmune diseases.
Co-immunoprecipitation, fluorescence resonance energy transfer (FRET), and pathway-specific assays elucidate IL17F's heterodimerization and signaling.
Comparative cytokine profiling, inflammatory assays, and pathway analysis dissect IL17F's interplay with other immune mediators.
Allergen challenges, inflammatory disease models, and gene expression profiling probe IL17F's involvement in chronic conditions.
Epithelial barrier permeability assays, tissue section analysis, and cell culture models study IL17F's effects on barrier integrity.
Wound healing assays, tissue regeneration models, and histological analyses examine IL17F's effects on tissue repair.
Customer Reviews (3)
Write a reviewHigh specificity.
Good for receptor studies.
Potent in anti-bacterial assays.
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