Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Active Recombinant Human OTULIN, GST-tagged

Cat.No. : OTULIN-157H
Product Overview : Recombinant human OTULIN (amino acid residues 1-352), fused with N-terminal GST, was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Description : There are two main classes of DUB, cysteine proteases and metalloproteases. OTULIN is a cysteine protease and a member of the OTU (ovarian tumour) superfamily of proteins (Balakirev et al., 2003). Cloning of the human gene was first described by Ota et al. (2004). OTU enzymes play important roles as negative-feedback regulators in NF-kB signalling, interferon signalling and in p97 (cdc48)-mediated processes although the cellular functions of most OTU enzymes remain to be discovered. Ovarian tumour family DUBs contain a papain-like catalytic core of ~180 amino acids.
Source : E. coli
Species : Human
Tag : GST
Form : 50 mM HEPES pH 7.5, 150 mM sodium chloride, 2 mM dithiothreitol, 10% glycerol
Bio-activity : Deubiquitylase Enzyme Assay: The activity of GST-OTULIN was validated by the monitoring of mono-ubiquitin generation as a result of the enzyme catalysed cleavage of linear di-ubiquitin. Incubation of the substrate in the presence or absence of GST-OTULIN was compared confirming the deubiquitylating activity of GST-OTULIN.
Molecular Mass : ~67kDa
Purity : >98% by SDS-PAGE
Storage : 12 months at -70°C. Avoid multiple freeze/thaw cycles.
Concentration : 0.5 mg/ml

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All OTULIN Products

Required fields are marked with *

My Review for All OTULIN Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends