Recombinant Full Length Human OTULIN Protein, His tagged

• Cat.No.: OTULIN-3666H
• Product Overview: Recombinant full-length human OTULIN was expressed in E. coli cells using an N-terminal His tag. The OTULIN gene accession number is NM_138348.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-352 aa
• Description: This gene encodes a member of the peptidase C65 family of ubiquitin isopeptidases. Members of this family remove ubiquitin from proteins. The encoded enzyme specifically recognizes and removes M1(Met1)-linked, or linear, ubiquitin chains from protein substrates. Linear ubiquitin chains are known to regulate the NF-kappa B signaling pathway in the context of immunity and inflammation. Mutations in this gene cause a potentially fatal autoinflammatory syndrome in human patients.
• Molecular Mass: 49 kDa
• Purity: > 90%
• Stability: One year at –70 centigrade from date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Storage Buffer: Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
• Concentration: 0.2 μg/μL
• Shipping: Dry ice

Gene Information

• Gene Name: OTULIN OTU deubiquitinase with linear linkage specificity [ Homo sapiens (human) ]
• Official Symbol: OTULIN
• Synonyms: OTULIN; OTU deubiquitinase with linear linkage specificity; GUM; AIPDS; AIPDSA; IMD107; FAM105B; ubiquitin thioesterase otulin; OTU domain-containing deubiquitinase with linear linkage specificity; deubiquitinating enzyme otulin; family with sequence similarity 105, member B; ubiquitin thioesterase Gumby; EC 3.4.19.12
• Gene ID: 90268
• mRNA Refseq: NM_138348
• Protein Refseq: NP_612357
• MIM: 615712
• UniProt ID: Q96BN8