Active Recombinant Human PDE1C, GST-tagged PDE1C-1612H

Active Recombinant Human PDE1C, GST-tagged

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Cat.No. : PDE1C-1612H Optional Service: Optional requirements on this protein
Product Overview : Full-length recombinant human PDE1C was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1C, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex.
Source : Sf9 insect cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 445 nmol/min/mg
Molecular Mass : ~99 kDa
Protein length : Full Length
Purity : >90%
Applications : PDE Assay
Stability : 1 yr at -70oC from date of shipment.
Storage : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 ug/ul
Gene Name : PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa [ Homo sapiens ]
Official Symbol : PDE1C
Synonyms : PDE1C; phosphodiesterase 1C, calmodulin-dependent 70kDa; phosphodiesterase 1C, calmodulin dependent (70kD); calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1C; Hcam3; hCam-3; cam-PDE 1C; Human 3,5 cyclic nucleotide phosphodiesterase (HSPDE1C1A)
Gene ID : 5137
mRNA Refseq : NM_005020
Protein Refseq : NP_005011
MIM : 602987
UniProt ID : Q14123
Chromosome Location : 7p14.3
Pathway : Ca-dependent events; Calmodulin induced events; DAP12 interactions
Function : calmodulin binding; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; metal ion binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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