Recombinant Human PDE1C Protein, His-tagged

• Cat.No.: PDE1C-146H
• Product Overview: Recombinant Human PDE1C, transcript variant 4, fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta.
• Form: 50mM Tris, 8M Urea, pH8.0.
• Molecular Mass: 72 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa [ Homo sapiens ]
• Official Symbol: PDE1C
• Synonyms: PDE1C; phosphodiesterase 1C, calmodulin-dependent 70kDa; phosphodiesterase 1C, calmodulin dependent (70kD); calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1C; Hcam3; hCam-3; cam-PDE 1C; Human 3,5 cyclic nucleotide phosphodiesterase (HSPDE1C1A)
• Gene ID: 5137
• mRNA Refseq: NM_001191056
• Protein Refseq: NP_005011
• MIM: 602987
• UniProt ID: Q14123